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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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KIT L576P | melanoma | sensitive | Dasatinib | Case Reports/Case Series | Actionable | In a clinical study, two patients with melanoma harboring KIT L576P, one who had progressed on Gleevec (imatinib), demonstrated initial clinical benefit following treatment with Sprycel (dasatinib); however, one patient progressed after 3 months, and the other patient progressed after 4 months of treatment (PMID: 19671763). | 19671763 |
KIT L576P | melanoma | sensitive | Dasatinib | Preclinical - Cell culture | Actionable | In a preclinical study, Sprycel (dasatinib) inhibited MNK pathway activation and proliferation of melanoma cell lines harboring KIT L576P in culture (PMID: 29035277). | 29035277 |
PubMed Id | Reference Title | Details |
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(19671763) | Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates. | Full reference... |
(29035277) | MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma. | Full reference... |