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Molecular Profile | KIT exon11 |
Therapy | Imatinib |
Indication/Tumor Type | melanoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT exon11 | melanoma | predicted - sensitive | Imatinib | Case Reports/Case Series | Actionable | In a clinical case study, Gleevec (imatinib) treatment resulted in a partial response in a patient with metastastic anal melanoma harboring a 21 base-pair duplication in KIT exon 11, and reduced pulmonary metastasis by 60% (PMID: 20372153). | 20372153 |
PubMed Id | Reference Title | Details |
---|---|---|
(20372153) | Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT. | Full reference... |