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| Molecular Profile | KIT K642E |
| Therapy | Imatinib |
| Indication/Tumor Type | vulvar melanoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT K642E | vulvar melanoma | predicted - sensitive | Imatinib | Case Reports/Case Series | Actionable | In a clinical case study, Gleevec (imatinib) treatment resulted in partial response in a patient with recurrent vulval melanoma harboring KIT K642E, with reduction of tumor mass by 35% at 12 weeks (PMID: 20372153). | 20372153 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (20372153) | Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT. | Full reference... |