Profile Response Detail

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Molecular Profile KIT K642E
Therapy Imatinib
Indication/Tumor Type vulvar melanoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT K642E vulvar melanoma predicted - sensitive Imatinib Case Reports/Case Series Actionable In a clinical case study, Gleevec (imatinib) treatment resulted in partial response in a patient with recurrent vulval melanoma harboring KIT K642E, with reduction of tumor mass by 35% at 12 weeks (PMID: 20372153). 20372153
PubMed Id Reference Title Details
(20372153) Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT. Full reference...