Profile Response Detail

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
KIT L576P	melanoma	predicted - sensitive	Imatinib	Case Reports/Case Series	Actionable	In a clinical case study, Gleevec (imatinib) treatment resulted in a 42% reduction of target lesions and an improvement of symptoms in a patient with metastasized labial melanoma harboring KIT L576P (PMID: 20372153).	20372153
KIT L576P	melanoma	predicted - sensitive	Imatinib	Case Reports/Case Series	Actionable	In a Phase II trial, Gleevec (imatinib) treatment resulted in a durable objective response rate of 16% (4/25, 2 complete and 2 partial responses), a median time-to-progression of 12 weeks, and a median survival from treatment initiation of 46.3 weeks in patients with melanoma harboring KIT mutations, including 2 complete, 1 partial, 1 transient partial response, and 1 stable disease in patients harboring KIT L576P (n=7) (PMID: 21642685; NCT00470470).	21642685
KIT L576P	melanoma	predicted - sensitive	Imatinib	Case Reports/Case Series	Actionable	In a Phase II trial, Gleevec (imatinib) treatment resulted in a best overall response rate of 53.8% (7/13, all partial responses) in patients with mucosal, acral, or chronically sun-damaged skin melanoma harboring KIT activating mutations in exons 11 (n=9), 13 (n=3), and 17 (n=1), including 3 partial responses and 1 with stable disease in patients with melanoma harboring KIT L576P (PMID: 23775962; NCT00424515).	23775962

PubMed Id	Reference Title	Details
(23775962)	Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin.	Full reference...
(20372153)	Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT.	Full reference...
(21642685)	KIT as a therapeutic target in metastatic melanoma.	Full reference...