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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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KIT D820Y | melanoma | predicted - sensitive | Sorafenib | Case Reports/Case Series | Actionable | In a clinical case study, Nexavar (sorafenib) treatment resulted in stable disease with 27% reduction in target lesions at 4 weeks in a patient with anal melanoma and pulmonary metastases harboring KIT D820Y (PMID: 20372153). | 20372153 |
PubMed Id | Reference Title | Details |
---|---|---|
(20372153) | Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT. | Full reference... |