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| Molecular Profile | MDM2 over exp TP53 wild-type |
| Therapy | MX69 |
| Indication/Tumor Type | acute lymphoblastic leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MDM2 over exp TP53 wild-type | acute lymphoblastic leukemia | sensitive | MX69 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, MX69 treatment induced cell death and inhibited cell growth in a TP53 wild-type acute lymphocytic leukemia cell line over expressing MDM2, and prolonged survival in xenograft models (PMID: 27666947). | 27666947 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27666947) | Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. | Full reference... |