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Molecular Profile | KIT V560G KIT D816V |
Therapy | BPR1J373 |
Indication/Tumor Type | mast-cell leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT V560G KIT D816V | mast-cell leukemia | sensitive | BPR1J373 | Preclinical - Cell culture | Actionable | In a preclinical study, a mast-cell leukemia cell line simultaneously harboring KIT D816V and KIT V560G was sensitive to BPR1J373 in culture, demonstrating inhibition of Kit phosphorylation and apoptotic activity (PMID: 27512117). | 27512117 |
PubMed Id | Reference Title | Details |
---|---|---|
(27512117) | BPR1J373, an Oral Multiple Tyrosine Kinase Inhibitor, Targets c-KIT for the Treatment of c-KIT-Driven Myeloid Leukemia. | Full reference... |