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| Molecular Profile | PBRM1 inact mut |
| Therapy | GSK126 |
| Indication/Tumor Type | kidney cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PBRM1 inact mut | kidney cancer | predicted - sensitive | GSK126 | Preclinical - Cell culture | Actionable | In a preclinical study, GSK126 inhibited growth of 3/4 tested renal cancer cell lines harboring PBRM1 inactivating mutations in culture, with inhibitor sensitivity associating with dependence on EZH2 catalytic activity (PMID: 26552009). | 26552009 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26552009) | SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. | Full reference... |