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| Molecular Profile | PTEN loss |
| Therapy | Alpelisib |
| Indication/Tumor Type | breast cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN loss | breast cancer | resistant | Alpelisib | Preclinical - Cell culture | Actionable | In a preclinical study, breast cancer cells harboring PTEN loss demonstrated resistance to Alpelisib (BYL719) in culture (PMID: 27604488). | 27604488 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27604488) | Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer. | Full reference... |