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Molecular Profile | PTEN loss |
Therapy | Alpelisib |
Indication/Tumor Type | breast cancer |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN loss | breast cancer | resistant | Alpelisib | Preclinical - Cell culture | Actionable | In a preclinical study, breast cancer cells harboring PTEN loss demonstrated resistance to Alpelisib (BYL719) in culture (PMID: 27604488). | 27604488 |
PubMed Id | Reference Title | Details |
---|---|---|
(27604488) | Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer. | Full reference... |