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Molecular Profile | FGFR1 pos FGFR2 pos |
Therapy | PHA-665752 |
Indication/Tumor Type | hepatocellular carcinoma |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR1 pos FGFR2 pos | hepatocellular carcinoma | no benefit | PHA-665752 | Preclinical - Cell culture | Actionable | In a preclinical study, PHA-665752 treatment did not result in decreased colony formation or reduced phosphorylation levels of FGFR1 and FGFR2 in hepatocellular carcinoma cells in culture (PMID: 26351320). | 26351320 |
PubMed Id | Reference Title | Details |
---|---|---|
(26351320) | Targeting FGFR Pathway in Human Hepatocellular Carcinoma: Expressing pFGFR and pMET for Antitumor Activity. | Full reference... |