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Molecular Profile BRAF V600E
Therapy PLX4720 + Selumetinib
Indication/Tumor Type high grade glioma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E high grade glioma predicted - sensitive PLX4720 + Selumetinib Preclinical - Cell line xenograft Actionable In a preclinical study, Selumetinib (AZD6244) and PLX4720 synergistically inhibited growth and induced apoptosis in glioma cell lines in culture, resulted in prolonged survival in cell line xenograft models (PMID: 27217440). 27217440
PubMed Id Reference Title Details
(27217440) BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas. Full reference...