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Molecular Profile | FGFR1 rearrange |
Therapy | Fexagratinib |
Indication/Tumor Type | leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR1 rearrange | leukemia | sensitive | Fexagratinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AZD4547 inhibited survival of leukemia cells harboring FGFR1 translocation in culture and in cell line xenograft models (PMID: 27550940). | 27550940 |
PubMed Id | Reference Title | Details |
---|---|---|
(27550940) | Identification of Pharmacodynamic Transcript Biomarkers in Response to FGFR Inhibition by AZD4547. | Full reference... |