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Molecular Profile | TP53 wild-type |
Therapy | Pegylated liposomal doxorubicin + RO6839921 |
Indication/Tumor Type | fibrosarcoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 wild-type | fibrosarcoma | sensitive | Pegylated liposomal doxorubicin + RO6839921 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, RO6839921 and Doxil combination treatment demonstrated sustained survival benefit in TP53 wild-type fibrosarcoma cell line xenograft models (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr A156). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Preclinical activity of MDM2 antagonist RO6839921, a pegylated prodrug for intravenous administration | Full reference... |