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Profile Treatment Approach Name | CDK4/6 Inhibitor |
Profile Name | CDKN2A E120* |
Drug Class | CDK4/6 Inhibitor 14 |
Therapy |
PubMed Id | Reference Title | Details |
---|---|---|
(24495407) | Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines. | Full reference... |
(23898052) | PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity. | Full reference... |