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Ref Type

Journal Article

PMID

(29736026)

Authors

Shen J, Ju Z, Zhao W, Wang L, Peng Y, Ge Z, Nagel ZD, Zou J, Wang C, Kapoor P, Ma X, Ma D, Liang J, Song S, Liu J, Samson LD, Ajani JA, Li GM, Liang H, Shen X, Mills GB, Peng G

Title

ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade.

Journal	Vol	Issue	Date	Pages	Journal Short Title
Nature medicine			2018 May 07	556-562	Nat Med

URL

Abstract Text

ARID1A (the AT-rich interaction domain 1A, also known as BAF250a) is one of the most commonly mutated genes in cancer1,2. The majority of ARID1A mutations are inactivating mutations and lead to loss of ARID1A expression 3 , which makes ARID1A a poor therapeutic target. Therefore, it is of clinical importance to identify molecular consequences of ARID1A deficiency that create therapeutic vulnerabilities in ARID1A-mutant tumors. In a proteomic screen, we found that ARID1A interacts with mismatch repair (MMR) protein MSH2. ARID1A recruited MSH2 to chromatin during DNA replication and promoted MMR. Conversely, ARID1A inactivation compromised MMR and increased mutagenesis. ARID1A deficiency correlated with microsatellite instability genomic signature and a predominant C>T mutation pattern and increased mutation load across multiple human cancer types. Tumors formed by an ARID1A-deficient ovarian cancer cell line in syngeneic mice displayed increased mutation load, elevated numbers of tumor-infiltrating lymphocytes, and PD-L1 expression. Notably, treatment with anti-PD-L1 antibody reduced tumor burden and prolonged survival of mice bearing ARID1A-deficient but not ARID1A-wild-type ovarian tumors. Together, these results suggest ARID1A deficiency contributes to impaired MMR and mutator phenotype in cancer, and may cooperate with immune checkpoint blockade therapy.

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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Showing 1 to 212 of 212 entries

Gene	Variant	Impact	Protein Effect	Variant Description
ARID1A	S11fs	frameshift	loss of function - predicted	ARID1A S11fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 11 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). S11fs has not been characterized, however, due to the effects of other truncation mutations downstream of S11 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	A35Gfs*76	frameshift	loss of function - predicted	ARID1A A35Gfs76 indicates a shift in the reading frame starting at amino acid 35 and terminating 76 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). A35Gfs76 has not been characterized however, due to the effects of other truncation mutations downstream of A35 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	P65Rfs*36	frameshift	loss of function - predicted	ARID1A P65Rfs36 indicates a shift in the reading frame starting at amino acid 65 and terminating 36 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). P65Rfs36 has not been characterized however, due to the effects of other truncation mutations downstream of P65 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G83Wfs*28	frameshift	loss of function - predicted	ARID1A G83Wfs28 indicates a shift in the reading frame starting at amino acid 83 and terminating 28 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). G83Wfs28 has not been characterized, however, due to the effects of other truncation mutations downstream of G83 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	P94Lfs*7	frameshift	loss of function - predicted	ARID1A P94Lfs7 indicates a shift in the reading frame starting at amino acid 94 and terminating 7 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). P94Lfs7 has not been characterized, however, due to the effects of other truncation mutations downstream of P94 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G108fs	frameshift	loss of function - predicted	ARID1A G108fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 108 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). G108fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of G108 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	P135Lfs*96	frameshift	loss of function - predicted	ARID1A P135Lfs96 indicates a shift in the reading frame starting at amino acid 135 and terminating 96 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). P135Lfs96 has not been characterized, however, due to the effects of other truncation mutations downstream of P135 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S138*	nonsense	loss of function - predicted	ARID1A S138* results in a premature truncation of the Arid1a protein at amino acid 138 of 2285 (UniProt.org). S138* has not been characterized, however, due to the effects of other truncation mutations downstream of S138 (PMID: 29736026, PMID: 26069190), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q199*	nonsense	loss of function - predicted	ARID1A Q199* results in a premature truncation of the Arid1a protein at amino acid 199 of 2285 (UniProt.org). Q199* has not been characterized, however, due to the effects of other truncation mutations downstream of Q199 (PMID: 29736026, PMID: 26069190), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q199fs	frameshift	loss of function - predicted	ARID1A Q199fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 199 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). Q199fs has not been characterized, however, due to the effects of other truncation mutations downstream of Q199 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	H203fs	frameshift	loss of function - predicted	ARID1A H203fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 203 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). H203fs has not been characterized, however, due to the effects of other truncation mutations downstream of H203 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	P224fs	frameshift	loss of function - predicted	ARID1A P224fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 224 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). P224fs has not been characterized, however, due to the effects of other truncation mutations downstream of P224 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	P224Rfs*8	frameshift	loss of function - predicted	ARID1A P224Rfs8 indicates a shift in the reading frame starting at amino acid 224 and terminating 8 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). P224Rfs8 has not been characterized, however, due to the effects of other truncation mutations downstream of P224 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S261*	nonsense	loss of function - predicted	ARID1A S261* results in a premature truncation of the Arid1a protein at amino acid 261 of 2285 (UniProt.org). S261* has not been characterized, however, due to the effects of other truncation mutations downstream of S261 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S264*	nonsense	loss of function - predicted	ARID1A S264* results in a premature truncation of the Arid1a protein at amino acid 264 of 2285 (UniProt.org). S264* has not been characterized, however, due to the effects of other truncation mutations downstream of S264 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q268*	nonsense	loss of function - predicted	ARID1A Q268* results in a premature truncation of the Arid1a protein at amino acid 268 of 2285 (UniProt.org). Q268* has not been characterized however, due to the effects of other truncation mutations downstream of Q268 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G272fs	frameshift	loss of function - predicted	ARID1A G272fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 272 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). G272fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of G272 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G276*	nonsense	loss of function - predicted	ARID1A G276* results in a premature truncation of the Arid1a protein at amino acid 276 of 2285 (UniProt.org). G276* has not been characterized, however, due to the effects of other truncation mutations downstream of G276 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G276Efs*87	frameshift	loss of function - predicted	ARID1A G276Efs87 indicates a shift in the reading frame starting at amino acid 276 and terminating 87 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). G276Efs87 has not been characterized, however, due to the effects of other truncation mutations downstream of G276 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G277fs	frameshift	loss of function - predicted	ARID1A G277fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 277 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). G277fs has not been characterized, however, due to the effects of other truncation mutations downstream of G277 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G283fs	frameshift	loss of function - predicted	ARID1A G283fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 283 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). G283fs has not been characterized, however, due to the effects of other truncation mutations downstream of G283 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G284fs	frameshift	loss of function - predicted	ARID1A G284fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 284 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). G284fs has not been characterized, however, due to the effects of other truncation mutations downstream of G284 (PMID: 29736026, PMID: 26069190), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q288Pfs*112	frameshift	loss of function - predicted	ARID1A Q288Pfs112 indicates a shift in the reading frame starting at amino acid 288 and terminating 112 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). Q288Pfs112 has not been characterized, however, due to the effects of other truncation mutations downstream of Q288 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	T292fs	frameshift	loss of function - predicted	ARID1A T292fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 292 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). T292fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of T292 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	T292Pfs*71	frameshift	loss of function - predicted	ARID1A T292Pfs71 indicates a shift in the reading frame starting at amino acid 292 and terminating 71 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). T292Pfs71 has not been characterized, however, due to the effects of other truncation mutations downstream of T292 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	T294Pfs*69	frameshift	loss of function - predicted	ARID1A T294Pfs69 indicates a shift in the reading frame starting at amino acid 294 and terminating 69 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). T294Pfs69 has not been characterized, however, due to the effects of other truncation mutations downstream of T294 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G319fs	frameshift	loss of function - predicted	ARID1A G319fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 319 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). G319fs has not been characterized, however, due to the effects of other truncation mutations downstream of G319 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q321Rfs*42	frameshift	loss of function - predicted	ARID1A Q321Rfs42 indicates a shift in the reading frame starting at amino acid 321 and terminating 42 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). Q321Rfs42 has not been characterized, however, due to the effects of other truncation mutations downstream of Q321 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	A339Gfs*61	frameshift	loss of function - predicted	ARID1A A339Gfs61 indicates a shift in the reading frame starting at amino acid 339 and terminating 61 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). A339Gfs61 has not been characterized, however, due to the effects of other truncation mutations downstream of A339 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	A339Lfs*24	frameshift	loss of function - predicted	ARID1A A339Lfs24 indicates a shift in the reading frame starting at amino acid 339 and terminating 24 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). A339Lfs24 has not been characterized, however, due to the effects of other truncation mutations downstream of A339 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S366Afs*25	frameshift	loss of function - predicted	ARID1A S366Afs25 indicates a shift in the reading frame starting at amino acid 366 and terminating 25 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). S366Afs25 has not been characterized, however, due to the effects of other truncation mutations downstream of S366 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q372*	nonsense	loss of function - predicted	ARID1A Q372* results in a premature truncation of the Arid1a protein at amino acid 372 of 2285 (UniProt.org). Q372* has not been characterized, however, due to the effects of other truncation mutations downstream of Q372 (PMID: 29736026, PMID: 26069190), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q372Afs*28	frameshift	loss of function - predicted	ARID1A Q372Afs28 indicates a shift in the reading frame starting at amino acid 372 and terminating 28 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). Q372Afs28 has not been characterized, however, due to the effects of other truncation mutations downstream of Q372 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q372fs	frameshift	loss of function - predicted	ARID1A Q372fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 372 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). Q372fs has not been characterized however, due to the effects of other truncation mutations downstream of Q372 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q372Sfs*19	frameshift	loss of function - predicted	ARID1A Q372Sfs19 indicates a shift in the reading frame starting at amino acid 372 and terminating 19 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). Q372Sfs19 has not been characterized, however, due to the effects of other truncation mutations downstream of Q372 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q393*	nonsense	loss of function - predicted	ARID1A Q393* results in a premature truncation of the Arid1a protein at amino acid 393 of 2285 (UniProt.org). Q393* has not been characterized, however, due to the effects of other truncation mutations downstream of Q393 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q393fs	frameshift	loss of function - predicted	ARID1A Q393fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 393 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). Q393fs has not been characterized, however, due to the effects of other truncation mutations downstream of Q393 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function
ARID1A	Y395*	nonsense	loss of function - predicted	ARID1A Y395* results in a premature truncation of the Arid1a protein at amino acid 395 of 2285 (UniProt.org). Y395* has not been characterized, however, due to the effects of other truncation mutations downstream of Y395 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q403*	nonsense	loss of function - predicted	ARID1A Q403* results in a premature truncation of the Arid1a protein at amino acid 403 of 2285 (UniProt.org). Q403* has not been characterized, however, due to the effects of other truncation mutations downstream of Q403 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q405*	nonsense	loss of function - predicted	ARID1A Q405* results in a premature truncation of the Arid1a protein at amino acid 405 of 2285 (UniProt.org). Q405* has not been characterized, however, due to the effects of other truncation mutations downstream of Q405 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q449*	nonsense	loss of function - predicted	ARID1A Q449* results in a premature truncation of the Arid1a protein at amino acid 449 of 2285 (UniProt.org). Q449* has not been characterized, however, due to the effects of other truncation mutations downstream of Q449 (PMID: 26069190, PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q474*	nonsense	loss of function - predicted	ARID1A Q474* results in a premature truncation of the Arid1a protein at amino acid 474 of 2285 (UniProt.org). Q474* has not been characterized, however, due to the effects of other truncation mutations downstream of Q474 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q479*	nonsense	loss of function - predicted	ARID1A Q479* results in a premature truncation of the Arid1a protein at amino acid 479 of 2285 (UniProt.org). Q479* has not been characterized, however, due to the effects of other truncation mutations downstream of Q479 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q480*	nonsense	loss of function - predicted	ARID1A Q480* results in a premature truncation of the Arid1a protein at amino acid 480 of 2285 (UniProt.org). Q480* has not been characterized, however, due to the effects of other truncation mutations downstream of Q480 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q502*	nonsense	loss of function - predicted	ARID1A Q502* results in a premature truncation of the Arid1a protein at amino acid 502 of 2285 (UniProt.org). Q502* results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of Q502 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q507fs	frameshift	loss of function - predicted	ARID1A Q507fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 507 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). Q507fs has not been characterized, however, due to the effects of other truncation mutations downstream of Q507 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q515*	nonsense	loss of function - predicted	ARID1A Q515* results in a premature truncation of the Arid1a protein at amino acid 515 of 2285 (UniProt.org). Q515* has not been characterized, however, due to the effects of other truncation mutations downstream of Q515 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Y518*	nonsense	loss of function - predicted	ARID1A Y518* results in a premature truncation of the Arid1a protein at amino acid 518 of 2285 (UniProt.org). Y518* has not been characterized, however, due to the effects of other truncation mutations downstream of Y518 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q528*	nonsense	loss of function - predicted	ARID1A Q528* results in a premature truncation of the Arid1a protein at amino acid 528 of 2285 (UniProt.org). Q528* has not been characterized, however, due to the effects of other truncation mutations downstream of Q528 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q537*	nonsense	loss of function - predicted	ARID1A Q537* results in a premature truncation of the Arid1a protein at amino acid 537 of 2285 (UniProt.org). Q537* has not been characterized, however, due to the effects of other truncation mutations downstream of Q537 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q543*	nonsense	loss of function - predicted	ARID1A Q543* results in a premature truncation of the Arid1a protein at amino acid 543 of 2285 (UniProt.org). Q543* has not been characterized, however, due to the effects of other truncation mutations downstream of Q543 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q546Rfs*73	frameshift	loss of function - predicted	ARID1A Q546Rfs73 indicates a shift in the reading frame starting at amino acid 546 and terminating 73 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). Q546Rfs73 has not been characterized, however, due to the effects of other truncation mutations downstream of Q546 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q548fs	frameshift	loss of function - predicted	ARID1A Q548fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 548 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). Q548fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of Q548 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	P549fs	frameshift	loss of function - predicted	ARID1A P549fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 549 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). P549fs has not been characterized, however, due to the effects of other truncation mutations downstream of P549 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Y551Lfs*72	frameshift	loss of function - predicted	ARID1A Y551Lfs72 indicates a shift in the reading frame starting at amino acid 551 and terminating 68 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). Y551Lfs72 has not been characterized, however, due to the effects of other truncation mutations downstream of Y551 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Y551Tfs*68	frameshift	loss of function - predicted	ARID1A Y551Tfs68 indicates a shift in the reading frame starting at amino acid 551 and terminating 68 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). Y551Tfs68 has not been characterized, however, due to the effects of other truncation mutations downstream of Y551 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S552*	nonsense	loss of function - predicted	ARID1A S552* results in a premature truncation of the Arid1a protein at amino acid 552 of 2285 (UniProt.org). S552* has not been characterized, however, due to the effects of other truncation mutations downstream of S552 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q566*	nonsense	loss of function - predicted	ARID1A Q566* results in a premature truncation of the Arid1a protein at amino acid 566 of 2285 (UniProt.org). Q566* has not been characterized, however, due to the effects of other truncation mutations downstream of Q566 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q581*	nonsense	loss of function - predicted	ARID1A Q581* results in a premature truncation of the Arid1a protein at amino acid 581 of 2285 (UniProt.org). Q581* results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of Q581 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S584fs	frameshift	loss of function - predicted	ARID1A S584fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 584 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). S584fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of S584 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q585*	nonsense	loss of function - predicted	ARID1A Q585* results in a premature truncation of the Arid1a protein at amino acid 585 of 2285 (UniProt.org). Q585* has not been characterized, however, due to the effects of other truncation mutations downstream of Q585 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q586*	nonsense	loss of function - predicted	ARID1A Q586* results in a premature truncation of the Arid1a protein at amino acid 586 of 2285 (UniProt.org). Q586* has not been characterized, however, due to the effects of other truncation mutations downstream of Q586 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Y592*	nonsense	loss of function - predicted	ARID1A Y592* results in a premature truncation of the Arid1a protein at amino acid 592 of 2285 (UniProt.org). Y592* has not been characterized, however, due to the effects of other truncation mutations downstream of Y592 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q611*	nonsense	loss of function - predicted	ARID1A Q611* results in a premature truncation of the Arid1a protein at amino acid 611 of 2285 (UniProt.org). Q611* has not been characterized, however, due to the effects of other truncation mutations downstream of Q611 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q611Rfs*11	frameshift	loss of function - predicted	ARID1A Q611Rfs11 indicates a shift in the reading frame starting at amino acid 611 and terminating 11 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). Q611Rfs11 has not been characterized, however, due to the effects of other truncation mutations downstream of Q611 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S617*	nonsense	loss of function - predicted	ARID1A S617* results in a premature truncation of the Arid1a protein at amino acid 617 of 2285 (UniProt.org). S617* has not been characterized, however, due to the effects of other truncation mutations downstream of S617 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S621fs	frameshift	loss of function - predicted	ARID1A S621fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 621 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). S621fs has not been characterized, however, due to the effects of other truncation mutations downstream of S621 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q633*	nonsense	loss of function - predicted	ARID1A Q633* results in a premature truncation of the Arid1a protein at amino acid 633 of 2285 (UniProt.org). Q633* has not been characterized, however, due to the effects of other truncation mutations downstream of Q633 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	E654Gfs*9	frameshift	loss of function - predicted	ARID1A E654Gfs9 indicates a shift in the reading frame starting at amino acid 654 and terminating 9 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). E654Gfs9 has not been characterized, however, due to the effects of other truncation mutations downstream of E654 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	L657Pfs*81	frameshift	loss of function - predicted	ARID1A L657Pfs81 indicates a shift in the reading frame starting at amino acid 657 and terminating 81 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). L657Pfs81 has not been characterized, however, due to the effects of other truncation mutations downstream of Q474 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S664*	nonsense	loss of function - predicted	ARID1A S664* results in a premature truncation of the Arid1a protein at amino acid 664 of 2285 (UniProt.org). S664* has not been characterized, however, due to the effects of other truncation mutations downstream of S664 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q670*	nonsense	loss of function - predicted	ARID1A Q670* results in a premature truncation of the Arid1a protein at amino acid 670 of 2285 (UniProt.org). Q670* has not been characterized, however, due to the effects of other truncation mutations downstream of Q670 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G671Efs*71	frameshift	loss of function - predicted	ARID1A G671Efs71 indicates a shift in the reading frame starting at amino acid 671 and terminating 71 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). G671Efs71 has not been characterized, however, due to the effects of other truncation mutations downstream of G671 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S674fs	frameshift	loss of function - predicted	ARID1A S674fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 674 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). S674fs has not been characterized, however, due to the effects of other truncation mutations downstream of S674 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	R693*	nonsense	loss of function - predicted	ARID1A R693* results in a premature truncation of the Arid1a protein at amino acid 693 of 2285 (UniProt.org). R693* has not been characterized, however, due to the effects of other truncation mutations downstream of R693 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S705fs	frameshift	loss of function - predicted	ARID1A S705fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 705 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). S705fs has not been characterized, however, due to the effects of other truncation mutations downstream of S705 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q708*	nonsense	loss of function - predicted	ARID1A Q708* results in a premature truncation of the Arid1a protein at amino acid 708 of 2285 (UniProt.org). Q708* has not been characterized, however, due to the effects of other truncation mutations downstream of Q708 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S711*	nonsense	loss of function - predicted	ARID1A S711* results in a premature truncation of the Arid1a protein at amino acid 711 of 2285 (UniProt.org). S711* has not been characterized, however, due to the effects of other truncation mutations downstream of S711 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	L714fs	frameshift	loss of function - predicted	ARID1A L714fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 714 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). L714fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of L714 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	P725fs	frameshift	loss of function - predicted	ARID1A P725fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 725 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). P725fs has not been characterized, however, due to the effects of other truncation mutations downstream of P725 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	P726fs	frameshift	loss of function - predicted	ARID1A P726fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 726 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). P726fs has not been characterized, however, due to the effects of other truncation mutations downstream of P726 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	R727fs	frameshift	loss of function - predicted	ARID1A R727fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 727 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). R727fs has not been characterized, however, due to the effects of other truncation mutations downstream of R727 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	R750*	nonsense	loss of function - predicted	ARID1A R750* results in a premature truncation of the Arid1a protein at amino acid 750 of 2285 (UniProt.org). R750* has not been characterized, however, due to the effects of other truncation mutations downstream of R750 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	N756fs	frameshift	loss of function - predicted	ARID1A N756fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 756 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). N756fs has not been characterized, however, due to the effects of other truncation mutations downstream of N756 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q758Rfs*75	frameshift	loss of function - predicted	ARID1A Q758Rfs75 indicates a shift in the reading frame starting at amino acid 758 and terminating 75 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). Q758Rfs75 has not been characterized, however, due to the effects of other truncation mutations downstream of Q758 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q766Pfs*51	frameshift	loss of function - predicted	ARID1A Q766Pfs51 indicates a shift in the reading frame starting at amino acid 766 and terminating 51 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). Q766Pfs51 has not been characterized, however, due to the effects of other truncation mutations downstream of Q766 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S769*	nonsense	loss of function - predicted	ARID1A S769* results in a premature truncation of the Arid1a protein at amino acid 769 of 2285 (UniProt.org). S769* has not been characterized, however, due to the effects of other truncation mutations downstream of S769 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	R774Efs*55	frameshift	loss of function - predicted	ARID1A R774Efs55 indicates a shift in the reading frame starting at amino acid 774 and terminating 55 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). R774Efs55 has not been characterized, however, due to the effects of other truncation mutations downstream of R774 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Y788*	nonsense	loss of function - predicted	ARID1A Y788* results in a premature truncation of the Arid1a protein at amino acid 788 of 2285 (UniProt.org). Y788* has not been characterized, however, due to the effects of other truncation mutations downstream of Y788 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q790*	nonsense	loss of function - predicted	ARID1A Q790* results in a premature truncation of the Arid1a protein at amino acid 790 of 2285 (UniProt.org). Q790* has not been characterized, however, due to the effects of other truncation mutations downstream of Q790 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q802Vfs*32	frameshift	loss of function - predicted	ARID1A Q802Vfs32 indicates a shift in the reading frame starting at amino acid 802 and terminating 32 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). Q802Vfs32 has not been characterized, however, due to the effects of other truncation mutations downstream of Q802 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Y823fs	frameshift	loss of function - predicted	ARID1A Y823fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 823 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). Y823fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of Y823 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S825fs	frameshift	loss of function - predicted	ARID1A S825fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 825 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). S825fs has not been characterized, however, due to the effects of other truncation mutations downstream of S825 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	I832fs	frameshift	loss of function - predicted	ARID1A I832fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 832 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). I832fs has not been characterized, however, due to the effects of other truncation mutations downstream of I832 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q878*	nonsense	loss of function - predicted	ARID1A Q878* results in a premature truncation of the Arid1a protein at amino acid 878 of 2285 (UniProt.org). Q878* has not been characterized, however, due to the effects of other truncation mutations downstream of Q878 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	P886Tfs*49	frameshift	loss of function - predicted	ARID1A P886Tfs49 indicates a shift in the reading frame starting at amino acid 886 and terminating 49 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). P886Tfs49 has not been characterized, however, due to the effects of other truncation mutations downstream of P886 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	E896*	nonsense	loss of function - predicted	ARID1A E896* results in a premature truncation of the Arid1a protein at amino acid 896 of 2285 (UniProt.org). E896* has not been characterized, however, due to the effects of other truncation mutations downstream of E896 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	T897Lfs*22	frameshift	loss of function - predicted	ARID1A T897Lfs22 indicates a shift in the reading frame starting at amino acid 897 and terminating 22 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). T897Lfs22 has not been characterized, however, due to the effects of other truncation mutations downstream of T897 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	I908fs	frameshift	loss of function - predicted	ARID1A I908fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 908 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). I908fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of I908 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	N917fs	frameshift	loss of function - predicted	ARID1A N917fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 917 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). N917fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of N917 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q920*	nonsense	loss of function - predicted	ARID1A Q920* results in a premature truncation of the Arid1a protein at amino acid 920 of 2285 (UniProt.org). Q920* has not been characterized, however, due to the effects of other truncation mutations downstream of Q920 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q920fs	frameshift	loss of function - predicted	ARID1A Q920fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 920 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). Q920fs has not been characterized, however, due to the effects of other truncation mutations downstream of Q920 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	M923Hfs*13	frameshift	loss of function - predicted	ARID1A M923Hfs13 indicates a shift in the reading frame starting at amino acid 923 and terminating 13 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). M923Hfs13 has not been characterized, however, due to the effects of other truncation mutations downstream of M923 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G925*	nonsense	loss of function - predicted	ARID1A G925* results in a premature truncation of the Arid1a protein at amino acid 925 of 2285 (UniProt.org). G925* has not been characterized, however, due to the effects of other truncation mutations downstream of G925 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q944*	nonsense	loss of function - predicted	ARID1A Q944* results in a premature truncation of the Arid1a protein at amino acid 944 of 2285 (UniProt.org). Q944* has not been characterized, however, due to the effects of other truncation mutations downstream of Q944 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S958Lfs*10	frameshift	loss of function - predicted	ARID1A S958Lfs10 indicates a shift in the reading frame starting at amino acid 958 and terminating 10 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). S958Lfs10 has not been characterized, however, due to the effects of other truncation mutations downstream of S958 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	T979fs	frameshift	loss of function - predicted	ARID1A T979fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 979 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). T979fs has not been characterized, however, due to the effects of other truncation mutations downstream of T979 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	E992*	nonsense	loss of function - predicted	ARID1A E992* results in a premature truncation of the Arid1a protein at amino acid 992 of 2285 (UniProt.org). E992* has not been characterized, however, due to the effects of other truncation mutations downstream of E992 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	T1003fs	frameshift	loss of function - predicted	ARID1A T1003fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1003 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). T1003fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of T1003 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	E1006*	nonsense	loss of function - predicted	ARID1A E1006* results in a premature truncation of the Arid1a protein at amino acid 1006 of 2285 (UniProt.org). E1006* has not been characterized, however, due to the effects of other truncation mutations downstream of E1006 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	K1071fs	frameshift	loss of function - predicted	ARID1A K1071fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1071 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). K1071fs has not been characterized, however, due to the effects of other truncation mutations downstream of K1071 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	K1072Nfs*21	frameshift	loss of function - predicted	ARID1A K1072Nfs21 indicates a shift in the reading frame starting at amino acid 1072 and terminating 21 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). K1072Nfs21 has not been characterized, however, due to the effects of other truncation mutations downstream of K1072 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	W1073*	nonsense	loss of function - predicted	ARID1A W1073* results in a premature truncation of the Arid1a protein at amino acid 1073 of 2285 (UniProt.org). W1073* has not been characterized, however, due to the effects of other truncation mutations downstream of W1073 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	L1092*	nonsense	loss of function - predicted	ARID1A L1092* results in a premature truncation of the Arid1a protein at amino acid 1092 of 2285 (UniProt.org). L1092* has not been characterized, however, due to the effects of other truncation mutations downstream of L1092 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1095*	nonsense	loss of function - predicted	ARID1A Q1095* results in a premature truncation of the Arid1a protein at amino acid 1095 of 2285 (UniProt.org). Q1095* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1095 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	F1118fs	frameshift	loss of function - predicted	ARID1A F1118fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1118 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). F1118fs has not been characterized, however, due to the effects of other truncation mutations downstream of F1118 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1131*	nonsense	loss of function - predicted	ARID1A Q1131* results in a premature truncation of the Arid1a protein at amino acid 1131 of 2285 (UniProt.org). Q1131* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1131 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1142*	nonsense	loss of function - predicted	ARID1A Q1142* results in a premature truncation of the Arid1a protein at amino acid 1142 of 2285 (UniProt.org). Q1142* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1142 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1148*	nonsense	loss of function - predicted	ARID1A Q1148* results in a premature truncation of the Arid1a protein at amino acid 1148 of 2285 (UniProt.org). Q1148* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1148 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S1149*	nonsense	loss of function - predicted	ARID1A S1149* results in a premature truncation of the Arid1a protein at amino acid 1149 of 2285 (UniProt.org). S1149* has not been characterized, however, due to the effects of other truncation mutations downstream of S1149 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S1153fs	frameshift	loss of function - predicted	ARID1A S1153fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1153 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). S1153fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of S1153 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	M1154fs	frameshift	loss of function - predicted	ARID1A M1154fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1154 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). M1154fs has not been characterized, however, due to the effects of other truncation mutations downstream of M1154 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1172*	nonsense	loss of function - predicted	ARID1A Q1172* results in a premature truncation of the Arid1a protein at amino acid 1172 of 2285 (UniProt.org). Q1172* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1172 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S1184fs	frameshift	loss of function - predicted	ARID1A S1184fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1184 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). S1184fs has not been characterized, however, due to the effects of other truncation mutations downstream of S1184 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	N1192fs	frameshift	loss of function - predicted	ARID1A N1192fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1192 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). N1192fs has not been characterized, however, due to the effects of other truncation mutations downstream of N1192 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1200*	nonsense	loss of function - predicted	ARID1A Q1200* results in a premature truncation of the Arid1a protein at amino acid 1200 of 2285 (UniProt.org). Q1200* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1200 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1212*	nonsense	loss of function - predicted	ARID1A Q1212* results in a premature truncation of the Arid1a protein at amino acid 1212 of 2285 (UniProt.org). Q1212* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1212 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	M1215fs	frameshift	loss of function - predicted	ARID1A M1215fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1215 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). M1215fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of M1215 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	M1224fs	frameshift	loss of function - predicted	ARID1A M1224fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1224 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). M1224fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), and due to the effects of other truncation mutations downstream of M1224 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S1248*	nonsense	loss of function - predicted	ARID1A S1248* results in a premature truncation of the Arid1a protein at amino acid 1248 of 2285 (UniProt.org). S1248* has not been characterized, however, due to the effects of other truncation mutations downstream of S1248 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1250*	nonsense	loss of function - predicted	ARID1A Q1250* results in a premature truncation of the Arid1a protein at amino acid 1250 of 2285 (UniProt.org). Q1250* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1250 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	N1270Mfs*19	frameshift	loss of function - predicted	ARID1A N1270Mfs19 indicates a shift in the reading frame starting at amino acid 1270 and terminating 19 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). N1270Mfs19 has not been characterized, however, due to the effects of other truncation mutations downstream of N1270 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	R1276*	nonsense	loss of function - predicted	ARID1A R1276* results in a premature truncation of the Arid1a protein at amino acid 1276 of 2285 (UniProt.org). R1276* has not been characterized, however, due to the effects of other truncation mutations downstream of R1276 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Y1285fs	frameshift	loss of function - predicted	ARID1A Y1285fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1285 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). Y1285fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of Y1285 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G1295fs	frameshift	loss of function - predicted	ARID1A G1295fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1295 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). G1295fs has not been characterized, however, due to the effects of other truncation mutations downstream of G1295 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	M1318fs	frameshift	loss of function - predicted	ARID1A M1318fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1318 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). M1318fs has not been characterized, however, due to the effects of other truncation mutations downstream of M1318 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Y1324fs	frameshift	loss of function - predicted	ARID1A Y1324fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1324 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). Y1324fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of Y1324 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	P1326Rfs*155	frameshift	loss of function - predicted	ARID1A P1326Rfs155 indicates a shift in the reading frame starting at amino acid 1326 and terminating 155 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). P1326Rfs155 has not been characterized, however, due to the effects of other truncation mutations downstream of P1326 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1327*	nonsense	loss of function - predicted	ARID1A Q1327* results in a premature truncation of the Arid1a protein at amino acid 1327 of 2285 (UniProt.org). Q1327* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1327 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1327Afs*11	frameshift	loss of function - predicted	ARID1A Q1327Afs11 indicates a shift in the reading frame starting at amino acid 1327 and terminating 11 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). Q1327Afs11 has not been characterized, however, due to the effects of other truncation mutations downstream of Q1327 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1327fs	frameshift	loss of function - predicted	ARID1A Q1327fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1327 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). Q1327fs has not been characterized, however, due to the effects of other truncation mutations downstream of Q1327 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	R1335*	nonsense	loss of function - predicted	ARID1A R1335* results in a premature truncation of the Arid1a protein at amino acid 1335 of 2285 (UniProt.org). R1335* has not been characterized, however, due to the effects of other truncation mutations downstream of R1335 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1342fs	frameshift	loss of function - predicted	ARID1A Q1342fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1342 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). Q1342fs has not been characterized, however, due to the effects of other truncation mutations downstream of Q1342 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1346*	nonsense	loss of function - predicted	ARID1A Q1346* results in a premature truncation of the Arid1a protein at amino acid 1346 of 2285 (UniProt.org). Q1346* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1346 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G1351fs	frameshift	loss of function - predicted	ARID1A G1351fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1351 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). G1351fs has not been characterized, however, due to the effects of other truncation mutations downstream of G1351 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	E1387*	nonsense	loss of function - predicted	ARID1A E1387* results in a premature truncation of the Arid1a protein at amino acid 1387 of 2285 (UniProt.org). E1387* has not been characterized, however, due to the effects of other truncation mutations downstream of E1387 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1397fs	frameshift	loss of function - predicted	ARID1A Q1397fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1397 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). Q1397fs has not been characterized, however, due to the effects of other truncation mutations downstream of Q1397 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1401*	nonsense	loss of function - predicted	ARID1A Q1401* results in a premature truncation of the Arid1a protein at amino acid 1401 of 2285 (UniProt.org). Q1401* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1401 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1403*	nonsense	loss of function - predicted	ARID1A Q1403* results in a premature truncation of the Arid1a protein at amino acid 1403 of 2285 (UniProt.org). Q1403* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1403 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1409*	nonsense	loss of function - predicted	ARID1A Q1409* results in a premature truncation of the Arid1a protein at amino acid 1409 of 2285 (UniProt.org). Q1409* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1409 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Y1431*	nonsense	loss of function - predicted	ARID1A Y1431* results in a premature truncation of the Arid1a protein at amino acid 1431 of 2285 (UniProt.org). Y1431* has not been characterized, however, due to the effects of other truncation mutations downstream of Y1431 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	R1446*	nonsense	loss of function - predicted	ARID1A R1446* results in a premature truncation of the Arid1a protein at amino acid 1446 of 2285 (UniProt.org). R1446* has not been characterized, however, due to the effects of other truncation mutations downstream of R1446 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G1450fs	frameshift	loss of function - predicted	ARID1A G1450fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1450 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). G1450fs has not been characterized, however, due to the effects of other truncation mutations downstream of G1450 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1454*	nonsense	loss of function - predicted	ARID1A Q1454* results in a premature truncation of the Arid1a protein at amino acid 1454 of 2285 (UniProt.org). Q1454* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1454 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	R1461*	nonsense	loss of function - predicted	ARID1A R1461* results in a premature truncation of the Arid1a protein at amino acid 1461 of 2285 (UniProt.org). R1461* has not been characterized, however, due to the effects of other truncation mutations downstream of R1461 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1474*	nonsense	loss of function - predicted	ARID1A Q1474* results in a premature truncation of the Arid1a protein at amino acid 1474 of 2285 (UniProt.org). Q1474* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1474 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1479*	nonsense	loss of function - predicted	ARID1A Q1479* results in a premature truncation of the Arid1a protein at amino acid 1479 of 2285 (UniProt.org). Q1479* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1479 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1493*	nonsense	loss of function - predicted	ARID1A Q1493* results in a premature truncation of the Arid1a protein at amino acid 1493 of 2285 (UniProt.org). Q1493* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1493 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1512*	nonsense	loss of function - predicted	ARID1A Q1512* results in a premature truncation of the Arid1a protein at amino acid 1512 of 2285 (UniProt.org). Q1512* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1512 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1519*	nonsense	loss of function - predicted	ARID1A Q1519* results in a premature truncation of the Arid1a protein at amino acid 1519 of 2285 (UniProt.org). Q1519* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1519 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1519fs	frameshift	loss of function - predicted	ARID1A Q1519fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1519 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). Q1519fs has not been characterized, however, due to the effects of other truncation mutations downstream of Q1519 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1519Pfs*13	frameshift	loss of function - predicted	ARID1A Q1519Pfs13 indicates a shift in the reading frame starting at amino acid 1519 and terminating 13 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). Q1519Pfs13 has not been characterized, however, due to the effects of other truncation mutations downstream of Q1519 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1519Rfs*8	frameshift	loss of function - predicted	ARID1A Q1519Rfs8 indicates a shift in the reading frame starting at amino acid 1519 and terminating 8 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). Q1519Rfs8 has not been characterized, however, due to the effects of other truncation mutations downstream of Q1519 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	A1522Pfs*5	frameshift	loss of function - predicted	ARID1A A1522Pfs5 indicates a shift in the reading frame starting at amino acid 1522 and terminating five residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). A1522Pfs5 has not been characterized, however, due to the effects of other truncation mutations downstream of A1522 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	R1528*	nonsense	loss of function - predicted	ARID1A R1528* results in a premature truncation of the Arid1a protein at amino acid 1528 of 2285 (UniProt.org). R1528* has not been characterized, however, due to the effects of other truncation mutations downstream of R1528 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	M1532fs	frameshift	loss of function - predicted	ARID1A M1532fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1532 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). M1532fs has not been characterized, however, due to the effects of other truncation mutations downstream of M1532 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	W1545*	nonsense	loss of function - predicted	ARID1A W1545* results in a premature truncation of the Arid1a protein at amino acid 1545 of 2285 (UniProt.org). W1545* has not been characterized, however, due to the effects of other truncation mutations downstream of W1545 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	A1559*	nonsense	loss of function - predicted	ARID1A A1559* results in a premature truncation of the Arid1a protein at amino acid 1559 of 2285 (UniProt.org). A1559* has not been characterized, however, due to the effects of other truncation mutations downstream of A1559 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	V1561fs	frameshift	loss of function - predicted	ARID1A V1561fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1561 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). V1561fs has not been characterized, however, due to the effects of other truncation mutations downstream of V1561 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1584*	nonsense	loss of function - predicted	ARID1A Q1584* results in a premature truncation of the Arid1a protein at amino acid 1584 of 2285 (UniProt.org). Q1584* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1584 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	E1596*	nonsense	loss of function - predicted	ARID1A E1596* results in a premature truncation of the Arid1a protein at amino acid 1596 of 2285 (UniProt.org). E1596* has not been characterized, however, due to the effects of other truncation mutations downstream of E1596 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	K1603*	nonsense	loss of function - predicted	ARID1A K1603* results in a premature truncation of the Arid1a protein at amino acid 1603 of 2285 (UniProt.org). K1603* has not been characterized, however, due to the effects of other truncation mutations downstream of K1603 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S1623*	nonsense	loss of function - predicted	ARID1A S1623* results in a premature truncation of the Arid1a protein at amino acid 1623 of 2285 (UniProt.org). S1623* has not been characterized, however, due to the effects of other truncation mutations downstream of S1623 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1631*	nonsense	loss of function - predicted	ARID1A Q1631* results in a premature truncation of the Arid1a protein at amino acid 1631 of 2285 (UniProt.org). Q1631* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1631 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	W1670*	nonsense	loss of function - predicted	ARID1A W1670* results in a premature truncation of the Arid1a protein at amino acid 1670 of 2285 (UniProt.org). W1670* has not been characterized, however, due to the effects of other truncation mutations downstream of W1670 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	A1682fs	frameshift	loss of function - predicted	ARID1A A1682fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1682 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). A1682fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1682 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G1711fs	frameshift	loss of function - predicted	ARID1A G1711fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1711 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). G1711fs has not been characterized, however, due to the effects of other truncation mutations downstream of G1711 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	E1718*	nonsense	loss of function - predicted	ARID1A E1718* results in a premature truncation of the Arid1a protein at amino acid 1718 of 2285 (UniProt.org). E1718* has not been characterized, however, due to the effects of other truncation mutations downstream of E1718 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	R1721*	nonsense	loss of function - predicted	ARID1A R1721* results in a premature truncation of the Arid1a protein at amino acid 1721 of 2285 (UniProt.org). R1721* has not been characterized, however, due to the effects of other truncation mutations downstream of R1721 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	R1721fs	frameshift	loss of function - predicted	ARID1A R1721fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1721 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). R1721fs has not been characterized, however, due to the effects of other truncation mutations downstream of R1721 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	R1722*	nonsense	loss of function - predicted	ARID1A R1722* results in a premature truncation of the Arid1a protein at amino acid 1722 of 2285 (UniProt.org). R1722* has not been characterized, however, due to the effects of other truncation mutations downstream of R1722 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	E1733*	nonsense	loss of function - predicted	ARID1A E1733* results in a premature truncation of the Arid1a protein at amino acid 1733 of 2285 (UniProt.org). E1733* has not been characterized, however, due to the effects of other truncation mutations downstream of E1733 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1741*	nonsense	loss of function - predicted	ARID1A Q1741* results in a premature truncation of the Arid1a protein at amino acid 1741 of 2285 (UniProt.org). Q1741* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1741 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	E1764*	nonsense	loss of function - predicted	ARID1A E1764* results in a premature truncation of the Arid1a protein at amino acid 1764 of 2285 (UniProt.org). E1764* has not been characterized, however, due to the effects of other truncation mutations downstream of E1764 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	E1776*	nonsense	loss of function - predicted	ARID1A E1776* results in a premature truncation of the Arid1a protein at amino acid 1776 of 2285 (UniProt.org). E1776* has not been characterized, however, due to the effects of other truncation mutations downstream of E1776 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	E1777*	nonsense	loss of function - predicted	ARID1A E1777* results in a premature truncation of the Arid1a protein at amino acid 1777 of 2285 (UniProt.org). E1777* has not been characterized, however, due to the effects of other truncation mutations downstream of E1777 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	E1780*	nonsense	loss of function - predicted	ARID1A E1780* results in a premature truncation of the Arid1a protein at amino acid 1780 of 2285 (UniProt.org). E1780* has not been characterized, however, due to the effects of other truncation mutations downstream of E1780 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S1791*	nonsense	loss of function - predicted	ARID1A S1791* results in a premature truncation of the Arid1a protein at amino acid 1791 of 2285 (UniProt.org). S1791* has not been characterized, however, due to the effects of other truncation mutations downstream of S1791 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	E1799fs	frameshift	loss of function - predicted	ARID1A E1799fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1799 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). E1799fs has not been characterized, however, due to the effects of other truncation mutations downstream of E1799 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	F1823fs	frameshift	loss of function - predicted	ARID1A F1823fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1823 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). F1823fs has not been characterized, however, due to the effects of other truncation mutations downstream of F1823 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1835*	nonsense	loss of function - predicted	ARID1A Q1835* results in a premature truncation of the Arid1a protein at amino acid 1835 of 2285 (UniProt.org). Q1835* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1835 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	E1836*	nonsense	loss of function - predicted	ARID1A E1836* results in a premature truncation of the Arid1a protein at amino acid 1836 of 2285 (UniProt.org). E1836* has not been characterized, however, due to the effects of other truncation mutations downstream of E1836 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	D1838*	nonsense	loss of function - predicted	ARID1A D1838* results in a premature truncation of the Arid1a protein at amino acid 1838 of 2285 (UniProt.org). D1838* has not been characterized, however, due to the effects of other truncation mutations downstream of D1838 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G1847fs	frameshift	loss of function - predicted	ARID1A G1847fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1847 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). G1847fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of G1847 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	G1848fs	frameshift	loss of function - predicted	ARID1A G1848fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1848 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). G1848fs is associated with loss of Arid1a protein expression in culture (PMID: 27486766), and due to the effects of other truncation mutations downstream of G1848 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	D1850fs	frameshift	loss of function - predicted	ARID1A D1850fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1850 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). D1850fs has not been characterized, however, due to the effects of other truncation mutations downstream of D1850 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	D1850Gfs*4	frameshift	loss of function - predicted	ARID1A D1850Gfs4 indicates a shift in the reading frame starting at amino acid 1850 and terminating 4 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). D1850Gfs4 has not been characterized, however, due to the effects of other truncation mutations downstream of D1850 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1856*	nonsense	loss of function - predicted	ARID1A Q1856* results in a premature truncation of the Arid1a protein at amino acid 1856 of 2285 (UniProt.org). Q1856* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1856 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	F1859fs	frameshift	loss of function - predicted	ARID1A F1859fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1859 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). F1859fs results in a loss of Arid1a protein expression in a patient sample (PMID: 32868822), but has not been fully biochemically characterized, however, due to the effects of other truncation mutations downstream of F1859 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	L1866fs	frameshift	loss of function - predicted	ARID1A L1866fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1866 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). L1866fs has not been characterized, however, due to the effects of other truncation mutations downstream of L1866 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	P1867fs	frameshift	loss of function - predicted	ARID1A P1867fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1867 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). P1867fs has not been characterized, however, due to the effects of other truncation mutations downstream of P1867 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	S1868fs	frameshift	loss of function - predicted	ARID1A S1868fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1868 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). S1868fs has not been characterized, however, due to the effects of other truncation mutations downstream of S1868 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	Q1894*	nonsense	loss of function - predicted	ARID1A Q1894* results in a premature truncation of the Arid1a protein at amino acid 1894 of 2285 (UniProt.org). Q1894* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1894 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	P1898Hfs*25	frameshift	loss of function - predicted	ARID1A P1898Hfs25 indicates a shift in the reading frame starting at amino acid 1898 and terminating 25 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). P1898Hfs25 has not been characterized, however, due to the effects of other truncation mutations downstream of P1898 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	K1953Rfs*3	frameshift	loss of function - predicted	ARID1A K1953Rfs3 indicates a shift in the reading frame starting at amino acid 1953 and terminating three residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). K1953Rfs3 has not been characterized, however, due to the effects of other truncation mutations downstream of K1953 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	I1954fs	frameshift	loss of function - predicted	ARID1A I1954fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1954 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). I1954fs has not been characterized, however, due to the effects of other truncation mutations downstream of I1954 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	I1954Nfs*9	frameshift	loss of function - predicted	ARID1A I1954Nfs9 indicates a shift in the reading frame starting at amino acid 1954 and terminating 9 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). I1954Nfs9 has not been characterized, however, due to the effects of other truncation mutations downstream of I1954 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	E1964*	nonsense	loss of function - predicted	ARID1A E1964* results in a premature truncation of the Arid1a protein at amino acid 1964 of 2285 (UniProt.org). E1964* has not been characterized, however, due to the effects of other truncation mutations downstream of E1964 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	W1973*	nonsense	loss of function - predicted	ARID1A W1973* results in a premature truncation of the Arid1a protein at amino acid 1973 of 2285 (UniProt.org). W1973* has not been characterized, however, due to the effects of other truncation mutations downstream of W1973 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	A1978Sfs*36	frameshift	loss of function - predicted	ARID1A A1978Sfs36 indicates a shift in the reading frame starting at amino acid 1978 and terminating 36 residues downstream causing a premature truncation of the 2285 amino acid Arid1a protein (UniProt.org). A1978Sfs36 has not been characterized, however, due to the effects of other truncation mutations downstream of A1978 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	V1982fs	frameshift	loss of function - predicted	ARID1A V1982fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1982 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). V1982fs has not been characterized, however, due to the effects of other truncation mutations downstream of V1982 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
ARID1A	R1989*	nonsense	loss of function - predicted	ARID1A R1989* results in a premature truncation of the Arid1a protein at amino acid 1989 of 2285 (UniProt.org). R1989* is associated with loss of Arid1a protein expression in cell culture (PMID: 29736026) and results in decreased Arid1a protein expression and decreased binding with Baf subunits in culture (PMID: 34386776), and therefore, is predicted to lead to a loss of Arid1a protein function.

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
ARID1A loss	colon cancer	predicted - sensitive	unspecified PD-L1 antibody	Preclinical - Cell line xenograft	Actionable	In a preclinical study, ARID1A-deficient colon cancer xenograft models demonstrated an increased response to treatment with an anti-PD-L1 antibody compared to controls (PMID: 29736026).	29736026
ARID1A loss	ovarian cancer	predicted - sensitive	unspecified PD-L1 antibody	Preclinical	Actionable	In a preclinical study, an ARID1A-deficient orthotopic ovarian cancer mouse model treated with a PD-L1 antibody demonstrated improved survival and greater decreased tumor volume compared to those treated with control (PMID: 29736026).	29736026

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