Reference Detail

Ref Type

Journal Article

PMID

(24705026)

Authors

Plaza-Menacho I, Mologni L, McDonald NQ

Title

Mechanisms of RET signaling in cancer: current and future implications for targeted therapy.

Journal	Vol	Issue	Date	Pages	Journal Short Title
Cellular signalling	26	8	2014 Aug	1743-52	Cell Signal

URL

Abstract Text

De-regulation of RET signaling by oncogenic mutation, gene rearrangement, overexpression or transcriptional up-regulation is implicated in several human cancers of neuroendocrine and epithelial origin (thyroid, breast, lung). Understanding how RET signaling mechanisms associated with these oncogenic events are deregulated, and their impact in the biological processes driving tumor formation and progression, as well as response to treatment, will be crucial to find and develop better targeted therapeutic strategies. In this review we emphasie the distinct mechanisms of RET signaling in cancer and summarise current knowledge on small molecule inhibitors targeting the tyrosine kinase domain of RET as therapeutic drugs in RET-positive cancers.

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Showing 1 to 71 of 71 entries

Molecular Profile	Treatment Approach
RET A510V	RET Inhibitor
RET A883F	RET Inhibitor
RET A883T	RET Inhibitor
RET act mut	RET Inhibitor
RET amp	RET Inhibitor
RET C515S	RET Inhibitor
RET C515W	RET Inhibitor
RET C531R	RET Inhibitor
RET C609R	RET Inhibitor
RET C609S	RET Inhibitor
RET C609Y	RET Inhibitor
RET C611W	RET Inhibitor
RET C611Y	RET Inhibitor
RET C618F	RET Inhibitor
RET C618G	RET Inhibitor
RET C618R	RET Inhibitor
RET C618S	RET Inhibitor
RET C618Y	RET Inhibitor
RET C620R	RET Inhibitor
RET C620S	RET Inhibitor
RET C620Y	RET Inhibitor
RET C630del	RET Inhibitor
RET C630F	RET Inhibitor
RET C630G	RET Inhibitor
RET C630R	RET Inhibitor
RET C630S	RET Inhibitor
RET C630Y	RET Inhibitor
RET C634_R635insHELC	RET Inhibitor
RET C634F	RET Inhibitor
RET C634G	RET Inhibitor
RET C634L	RET Inhibitor
RET C634R	RET Inhibitor
RET C634S	RET Inhibitor
RET C634W	RET Inhibitor
RET C634Y	RET Inhibitor
RET D567N	RET Inhibitor
RET D567Y	RET Inhibitor
RET D584N	RET Inhibitor
RET D631Y	RET Inhibitor
RET D898_E901del	RET Inhibitor
RET E505_G506del	RET Inhibitor
RET E511K	RET Inhibitor
RET E574D	RET Inhibitor
RET E616Q	RET Inhibitor
RET E632_L633del	RET Inhibitor
RET E768D	RET Inhibitor
RET E805K	RET Inhibitor
RET G533C	RET Inhibitor
RET G607C	RET Inhibitor
RET I852M	RET Inhibitor
RET K666E	RET Inhibitor
RET K666N	RET Inhibitor
RET L633_C634dup	RET Inhibitor
RET M848T	RET Inhibitor
RET M918T	RET Inhibitor
RET M918V	RET Inhibitor
RET R833C	RET Inhibitor
RET R886W	RET Inhibitor
RET R912P	RET Inhibitor
RET S409Y	RET Inhibitor
RET S649L	RET Inhibitor
RET S891A	RET Inhibitor
RET S904F	RET Inhibitor
RET T636M	RET Inhibitor
RET T930K	RET Inhibitor
RET T930P	RET Inhibitor
RET V292M	RET Inhibitor
RET V804L	RET Inhibitor
RET V804M	RET Inhibitor
RET Y606C	RET Inhibitor
RET Y806C	RET Inhibitor

Showing 1 to 71 of 71 entries

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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Therapy Name	Drugs	Efficacy Evidence	Clinical Trials
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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
No data available in table

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