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Ref Type Journal Article
PMID (24705026)
Authors Plaza-Menacho I, Mologni L, McDonald NQ
Title Mechanisms of RET signaling in cancer: current and future implications for targeted therapy.
Journal Vol Issue Date Pages Journal Short Title
Cellular signalling 26 8 2014 Aug 1743-52 Cell Signal
URL
Abstract Text De-regulation of RET signaling by oncogenic mutation, gene rearrangement, overexpression or transcriptional up-regulation is implicated in several human cancers of neuroendocrine and epithelial origin (thyroid, breast, lung). Understanding how RET signaling mechanisms associated with these oncogenic events are deregulated, and their impact in the biological processes driving tumor formation and progression, as well as response to treatment, will be crucial to find and develop better targeted therapeutic strategies. In this review we emphasie the distinct mechanisms of RET signaling in cancer and summarise current knowledge on small molecule inhibitors targeting the tyrosine kinase domain of RET as therapeutic drugs in RET-positive cancers.

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Molecular Profile Treatment Approach
RET C634W RET Inhibitor
RET R886W RET Inhibitor
RET S904F RET Inhibitor
RET E505_G506del RET Inhibitor
RET D567Y RET Inhibitor
RET C618G RET Inhibitor
RET M918T RET Inhibitor
RET C618Y RET Inhibitor
RET C515W RET Inhibitor
RET E805K RET Inhibitor
RET C531R RET Inhibitor
RET S649L RET Inhibitor
RET A510V RET Inhibitor
RET C634_R635insHELC RET Inhibitor
RET act mut RET Inhibitor
RET G607C RET Inhibitor
RET A883F RET Inhibitor
RET C620S RET Inhibitor
RET C634F RET Inhibitor
RET E616Q RET Inhibitor
RET M848T RET Inhibitor
RET C634R RET Inhibitor
RET K666E RET Inhibitor
RET R912P RET Inhibitor
RET C618S RET Inhibitor
RET T636M RET Inhibitor
RET C630G RET Inhibitor
RET I852M RET Inhibitor
RET C630Y RET Inhibitor
RET Y606C RET Inhibitor
RET C609R RET Inhibitor
RET G533C RET Inhibitor
RET E632_L633del RET Inhibitor
RET C620Y RET Inhibitor
RET D584N RET Inhibitor
RET C630F RET Inhibitor
RET T930P RET Inhibitor
RET V292M RET Inhibitor
RET C618R RET Inhibitor
RET D567N RET Inhibitor
RET C630del RET Inhibitor
RET C620R RET Inhibitor
RET T930K RET Inhibitor
RET C630S RET Inhibitor
RET D631Y RET Inhibitor
RET C634S RET Inhibitor
RET D898_E901del RET Inhibitor
RET C609Y RET Inhibitor
RET K666N RET Inhibitor
RET V804L RET Inhibitor
RET C618F RET Inhibitor
RET C630R RET Inhibitor
RET A883T RET Inhibitor
RET C634Y RET Inhibitor
RET C609S RET Inhibitor
RET R833C RET Inhibitor
RET E574D RET Inhibitor
RET V804M RET Inhibitor
RET amp RET Inhibitor
RET E511K RET Inhibitor
RET M918V RET Inhibitor
RET Y806C RET Inhibitor
RET C634G RET Inhibitor
RET S409Y RET Inhibitor
RET L633_C634dup RET Inhibitor
RET E768D RET Inhibitor
RET C611W RET Inhibitor
RET C515S RET Inhibitor
RET C611Y RET Inhibitor
RET C634L RET Inhibitor
RET S891A RET Inhibitor
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References