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Ref Type Journal Article
PMID (22293180)
Authors Sachdeva UM, O'Brien JM
Title Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma.
Journal Vol Issue Date Pages Journal Short Title
The Journal of clinical investigation 122 2 2012 Feb 425-34 J Clin Invest
URL
Abstract Text Retinoblastoma is a pediatric retinal tumor initiated by biallelic inactivation of the retinoblastoma gene (RB1). RB1 was the first identified tumor suppressor gene and has defined roles in the regulation of cell cycle progression, DNA replication, and terminal differentiation. However, despite the abundance of work demonstrating the molecular function and identifying binding partners of pRb, the challenge facing molecular biologists and clinical oncologists is how to integrate this vast body of molecular knowledge into the development of targeted therapies for treatment of retinoblastoma. We propose that a more thorough genetic understanding of retinoblastoma would inform targeted treatment decisions and could improve outcomes and quality of life in children affected by this disease.

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