Reference Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Ref Type Journal Article
PMID (37253112)
Authors Hu C, Belur Nagaraj A, Shimelis H, Montalban G, Lee KY, Huang H, Lumby CA, Na J, Susswein LR, Roberts ME, Marshall ML, Hiraki S, LaDuca H, Chao E, Yussuf A, Pesaran T, Neuhausen SL, Haiman CA, Kraft P, Lindström S, Palmer JR, Teras LR, Vachon CM, Yao S, Ong I, Nathanson KL, Weitzel JN, Boddicker N, Gnanaolivu R, Polley EC, Mer G, Cui G, Karam R, Richardson ME, Domchek SM, Yadav S, Hruska KS, Dolinsky J, Weroha SJ, Hart SN, Simard J, Masson JY, Pang YP, Couch FJ
Title Functional and clinical characterization of variants of uncertain significance identifies a hotspot for inactivating missense variants in RAD51C.
Journal Vol Issue Date Pages Journal Short Title
Cancer research 2023 May 30 Cancer Res
URL
Abstract Text Pathogenic protein-truncating variants of RAD51C, which plays an integral role in promoting DNA damage repair, increase the risk of breast and ovarian cancer. A large number of RAD51C missense variants of uncertain significance (VUS) have been identified, but the effects of the majority of these variants on RAD51C function and cancer predisposition have not been established. Here, analysis of 173 missense variants by a homology-directed repair (HDR) assay in reconstituted RAD51C-/- cells identified 30 non-functional (deleterious) variants, including 18 in a hotspot within the ATP binding region. The deleterious variants conferred sensitivity to cisplatin and olaparib and disrupted formation of RAD51C/XRCC3 and RAD51B/RAD51C/RAD51D/XRCC2 complexes. Computational analysis indicated the deleterious variant effects were consistent with structural effects on ATP-binding to RAD51C. A subset of the variants displayed similar effects on RAD51C activity in reconstituted human RAD51C depleted cancer cells. Case-control association studies of deleterious variants in women with breast and ovarian cancer and non-cancer controls showed associations with moderate breast cancer risk (odds ratio (OR)=3.92; 95%CI:2.18-7.59) and high ovarian cancer risk (OR=14.8; 95%CI:7.71-30.36), similar to protein-truncating variants. This functional data supports the clinical classification of inactivating RAD51C missense variants as pathogenic or likely pathogenic, which may improve the clinical management of variant carriers.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
RAD51C A155E missense loss of function RAD51C A155E does not lie within any known functional domains of the Rad51c protein (UniProt.org). A155E results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, decreased Rad51 foci formation, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C A279P missense loss of function RAD51C A279P does not lie within any known functional domains of the Rad51c protein (UniProt.org). A279P results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C D108G missense loss of function RAD51C D108G lies within the region required for Holliday junction resolution activity and the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). D108G results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, decreased Rad51 foci formation, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C D159A missense loss of function RAD51C D159A does not lie within any known functional domains of the Rad51c protein (UniProt.org). D159A results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C D159N missense unknown RAD51C D159N does not lie within any known functional domains of the Rad51c protein (UniProt.org). D159N demonstrates partial rescue of mitomycin C hypersensitivity in chicken cells and Rad51 foci formation similar to wild-type Rad51c in human cells in culture (PMID: 20400964), but in another study results in decreased binding to Brca2, Palb2, Rad51 (PMID: 24141787), and Rad51d and demonstrates loss of interaction with Xrcc3 in cell culture (PMID: 37253112), and binds to Rad51b and Rad51c at reduced levels but to Xrcc3 similar to wild-type protein in a yeast assay (PMID: 36099300), and therefore, its effect on Rad51c protein function is unknown.
RAD51C D159Y missense loss of function RAD51C D159Y does not lie within any known functional domains of the Rad51c protein (UniProt.org). D159Y results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, decreased Rad51 foci formation, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C D242N missense loss of function RAD51C D242N does not lie within any known functional domains of the Rad51c protein (UniProt.org). D242N results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C D348V missense loss of function RAD51C D348V does not lie within any known functional domains of the Rad51c protein (UniProt.org). D348V confers a loss of function to Rad51c as demonstrated by loss of interaction with Xrcc2, Xrcc3, and Rad51d and reduced homology-directed DNA repair activity in culture (PMID: 37253112).
RAD51C E36K missense unknown RAD51C E36K lies within the region required for Holliday junction resolution activity of the Rad51c protein (UniProt.org). E36K maintains functional homology-directed DNA repair activity in cell culture reporter assays (PMID: 42625895, PMID: 37253112), but demonstrates reduced binding to Rad51d and Xrcc3 in a yeast assay (PMID: 42625895), and therefore, its effect on Rad51 protein function is unknown.
RAD51C E45G missense no effect - predicted RAD51C E45G lies within a region of the Rad51c protein required for Holliday junction resolution activity (UniProt.org). E45G maintains functional homology-directed DNA repair activity in cell culture reporter assays (PMID: 42625895, PMID: 37253112), and demonstrates binding to Rad51d and Xrcc3 similar to wild-type Rad51c in a yeast assay (PMID: 42625895), and therefore, is predicted to have no effect on Rad51c protein function.
RAD51C E67G missense no effect - predicted RAD51C E67G lies within a region of the Rad51c protein required for Holliday junction resolution activity (UniProt.org). E67G maintains functional homology-directed DNA repair activity in cell culture reporter assays (PMID: 42625895, PMID: 37253112), and demonstrates binding to Rad51d and Xrcc3 similar to wild-type Rad51c in a yeast assay (PMID: 42625895), and therefore, is predicted to have no effect on Rad51c protein function.
RAD51C E92K missense no effect - predicted RAD51C E92K lies within a region of the Rad51c protein required for Holliday junction resolution activity and the RAD51B, RAD51D, and XRCC3-interacting region (UniProt.org). E92K maintains functional homology-directed DNA repair activity in a cell culture reporter assay (PMID: 37253112), and therefore, is predicted to have no effect on Rad51c protein function.
RAD51C G114R missense loss of function RAD51C G114R lies within the region required for Holliday junction resolution activity and the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). G114R results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C G114V missense loss of function RAD51C G114V lies within the region required for Holliday junction resolution activity and the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). G114V results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C G130R missense loss of function RAD51C G130R lies within the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). G130R results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, decreased colony formation, reduced Rad51 foci formation, and decreased homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C G150E missense loss of function RAD51C G150E does not lie within any known functional domains of the Rad51c protein (UniProt.org). G150E results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C G189R missense no effect - predicted RAD51C G189R does not lie within any known functional domains of the Rad51c protein (UniProt.org). G189R demonstrates functional homology-directed DNA repair activity in culture (PMID: 40670332, PMID: 37253112), retains binding to Rad51d similar to wild-type Rad51c in a yeast assay, and rescues viability in Rad51c-deficient cells (PMID: 40670332), and therefore is predicted to have no effect on Rad51c protein function.
RAD51C G302V missense loss of function - predicted RAD51C G302V does not lie within any known functional domains of the Rad51c protein (UniProt.org). G302V binds to Rad51d and Xrcc2 and results in colony formation similar to wild-type Rad51c, but results in loss of interaction with Xrcc3, altered Rad51 foci formation, and reduced homology-directed DNA repair activity in culture (PMID: 37253112), and therefore, is predicted to lead to a loss of Rad51c protein function.
RAD51C G306R missense unknown RAD51C G306R does not lie within any known functional domains of the Rad51c protein (UniProt.org). G306R results in altered homology-directed DNA repair activity and Rad51 foci formation in culture (PMID: 37253112), but has not been fully biochemically characterized and therefore, its effect on Rad51c protein function is unknown.
RAD51C G3R missense no effect - predicted RAD51C G3R lies within a region of the Rad51c protein required for Holliday junction resolution activity (UniProt.org). G3R demonstrates intermediate homology-directed DNA repair activity in one study (PMID: 42625895), but results in functional homology-directed DNA repair activity in a different study (PMID: 37253112), retains binding to Rad51d and Xrcc3 similar to wild-type Rad51c in a yeast assay (PMID: 42625895), and rescues mitomycin C hypersensitivity and Rad51 foci formation similar to wild-type Rad51c in culture (PMID: 20400964), and therefore, is predicted to have no effect on Rad51c protein function.
RAD51C K131I missense loss of function RAD51C K131I lies within the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). K131I results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, decreased colony formation, reduced Rad51 foci formation, and decreased homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C K235N missense loss of function - predicted RAD51C K235N does not lie within any known functional domains of the Rad51c protein (UniProt.org). K235N retains functional homology-directed DNA repair activity (PMID: 37253112, PMID: 42625895), and binding to Rad51d and Xrcc3 similar to wild-type Rad51c in culture (PMID: 42625895), however the genomic change (c.705G>C) leads to abnormal splicing leading to skipping of exon 4 and premature protein truncation in a minigene splicing assay (PMID: 33333735) and in patient cells (PMID: 35565380), and demonstrates decreased survival in a high-throughput cell culture assay (PMID: 39299233), and therefore, is predicted to lead to a loss of Rad51c protein function.
RAD51C K84N missense no effect - predicted RAD51C K84N lies within a region of the Rad51c protein required for Holliday junction resolution activity and the RAD51B, RAD51D, and XRCC3-interacting region of the Rad51c protein (UniProt.org). K84N retains binding to Rad51d similar to wild-type Rad51c in a yeast assay (PMID: 40670332), and demonstrates functional homology-directed DNA repair activity in culture (PMID: 40670332, PMID: 37253112), and therefore is predicted to have no effect on Rad51c protein function.
RAD51C L138F missense unknown RAD51C L138F does not lie within any known functional domains of the Rad51c protein (UniProt.org). L138F rescues survival in Rad51c-null cells and results in homologous recombination activity similar to wild-type Rad51c in one cell line but deficient activity in another in one study (PMID: 36099300), but demonstrates decreased homology-directed repair activity in another study (PMID: 37253112), decreased interaction with Xrcc2, Xrcc3, and Rad51d in culture (PMID: 37253112) and Rad51b, Rad51d, and Xrcc3 in a yeast assay (PMID: 36099300), decreased Rad51 foci formation (PMID: 20400964, PMID: 37253112), and fails to rescue mitomycin C hypersensitivity in culture (PMID: 20400964), and therefore, its effect on Rad51c protein function is unknown.
RAD51C L230F missense loss of function - predicted RAD51C L230F does not lie within any known functional domains of the Rad51c protein (UniProt.org). L230F retains homology-directed DNA repair activity similar to wild-type Rad51c in one study (PMID: 37253112), but demonstrates intermediate homology-directed DNA repair activity in a different study, and results in failure to rescue hypersensitivity to PARP and ATR inhibitors in Rad51c-deficient cells, and abnormal replication fork progression leading to accumulation of ssDNA breaks in culture (PMID: 42625895), and therefore, is predicted to lead to a loss of Rad51c protein function.
RAD51C L27P missense loss of function RAD51C L27P lies within the region of the Rad51c protein required for Holliday junction resolution activity (UniProt.org). L27P binds to Rad51b, Rad51d, and Xrcc3 to similar levels as wild-type protein in a yeast assay (PMID: 36099300), however, confers a loss of function to Rad51c as demonstrated by loss of binding to Rad51d and Xrcc2 in culture, failure to rescue hypersensitivity to cisplatin and PARP inhibitors in Rad51c-deficient cells (PMID: 37253112), reduced homologous recombination activity compared to wild-type Rad51c in cultured cells (PMID: 36099300, PMID: 37253112), and decreased survival in a high-throughput cell culture assay (PMID: 39299233).
RAD51C M10R missense unknown RAD51C M10R lies within the region required for Holliday junction resolution activity of the Rad51c protein (UniProt.org). M10R retains binding to Rad51d similar to wild-type Rad51c in a yeast assay (PMID: 40670332), demonstrates functional homology-directed DNA repair activity in cell culture (PMID: 37253112, PMID: 40670332), and rescues viability in Rad51c-deficient cells (PMID: 40670332), but results in decreased survival in a high-throughput cell culture assay (PMID: 39299233), and therefore, its effect on Rad51c protein function is unknown.
RAD51C M136I missense no effect - predicted RAD51C M136I lies within the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). M136I retains binding to Rad51d similar to wild-type Rad51c in a yeast assay (PMID: 40670332), and demonstrates functional homology-directed DNA repair activity in culture (PMID: 40670332, PMID: 37253112), and therefore is predicted to have no effect on Rad51c protein function.
RAD51C P21S missense no effect - predicted RAD51C P21S lies within a region of the Rad51c protein required for Holliday junction resolution activity (UniProt.org). P21S binds to Rad51b, Rad51d, and Xrcc3 to similar levels as wild-type protein in a yeast assay (PMID: 36099300) and retains the ability to induce foci formation in culture (PMID: 37253112), and therefore, is predicted to have no effect on Rad51c protein function.
RAD51C Q133E missense loss of function - predicted RAD51C Q133E lies within the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). Q133E binds to Rad51d and supports cell proliferation to similar levels as wild-type Rad51c, but results in loss of interaction with Xrcc3, partial loss of interaction with Xrcc2, and reduced homology-directed DNA repair activity in culture (PMID: 37253112), and therefore, is predicted to lead to a loss of Rad51c protein function.
RAD51C R168G missense loss of function RAD51C R168G does not lie within any known functional domains of the Rad51c protein (UniProt.org). R168G results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, decreased colony formation, reduced Rad51 foci formation, and decreased homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C R212H missense unknown RAD51C R212H does not lie within any known functional domains of the Rad51c protein (UniProt.org). R212H retains homology-directed DNA repair activity similar to wild-type Rad51c in one study (PMID: 37253112), but demonstrates intermediate homology-directed DNA repair activity in a different study, and results in abnormal replication fork progression leading to accumulation of single strand DNA breaks in culture (PMID: 42625895), and therefore, its effect on Rad51c protein function is unknown.
RAD51C R214C missense unknown RAD51C R214C does not lie within any known functional domains of the Rad51c protein (UniProt.org). R214C results in decreased interaction with Xrcc3 and Rad51b in a yeast-two-hybrid assay in one study (PMID: 21980511), but in another study binds to Rad51b, Rad51d, and Xrcc3 to similar levels of wild-type protein in a yeast assay (PMID: 36099300) and demonstrates homology-directed repair activity in cultured cells (PMID: 37253112), and therefore, its effect on Rad51c protein function is unknown.
RAD51C R237P missense loss of function RAD51C R237P does not lie within any known functional domains of the Rad51c protein (UniProt.org). R237P results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C R249C missense unknown RAD51C R249C does not lie within any known functional domains of the Rad51c protein (UniProt.org). R249C binds to Rad51b, Rad51d, and Xrcc3 at similar levels as wild-type protein in a yeast assay, rescues survival in Rad51c-null cells, and demonstrates homologous recombination activity similar to wild-type Rad51c in two cell lines in culture (PMID: 36099300, PMID: 37253112), but results in intermediate homologous recombination activity in a different cell line in culture (PMID: 36099300), and demonstrates decreased survival in a high-throughput cell culture assay (PMID: 39299233), and therefore, its effect on Rad51c protein function is unknown.
RAD51C R24L missense unknown RAD51C R24L lies within a region of the Rad51c protein required for Holliday junction resolution activity (UniProt.org). R24L maintains functional homology-directed DNA repair activity in cell culture (PMID: 37253112), and retains the ability to complement hypersensitivity to mitomycin C and etoposide in RAD51C-deficient cells, but demonstrates impaired ability to rescue survival of RAD51C-deficient cells upon PARP inhibitor treatment in culture (PMID: 36562461), and results in decreased survival in a high-throughput cell culture assay (PMID: 39299233), and therefore, its effect on Rad51c protein function is unknown.
RAD51C R366Q missense loss of function - predicted RAD51C R366Q does not lie within any known functional domains of the Rad51c protein (UniProt.org). R366Q results in similar Rad51b, Rad51d, and Xrcc3 binding in yeast assays (PMID: 36099300), Rad51 foci formation similar to wild-type in culture (PMID: 20400964), and rescues sensitivity to DNA damage and homologous recombination (HR) repair activity in RAD51C-null cells in culture (PMID: 37253112), but results in partial rescue of mitomycin C sensitivity (PMID: 20400964, PMID: 22167183), moderately increased chromosomal aberrations, reduced G2/M accumulation (PMID: 22167183), and partially decreased HR activity in reporter assays (PMID: 22167183, PMID: 25292178), and therefore, is predicted to lead to a loss of Rad51 protein function.
RAD51C S163R missense loss of function RAD51C S163R does not lie within any known functional domains of the Rad51c protein (UniProt.org). S163R binds to Rad51d to similar levels of wild-type Rad51c, but results in loss of interaction with Xrcc3, partial loss of interaction with Xrcc2, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C S364G missense no effect - predicted RAD51C S364G does not lie within any known functional domains of the Rad51c protein (UniProt.org). S364G retains binding to Rad51d similar to wild-type Rad51c in a yeast assay, and demonstrates functional homology-directed DNA repair activity in culture (PMID: 40670332, PMID: 37253112), and therefore is predicted to have no effect on Rad51c protein function.
RAD51C T102I missense loss of function RAD51C T102I lies within the region required for Holliday junction resolution activity and the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). T102I confers a loss of function to Rad51c as demonstrated by loss of interaction with Xrcc2, Xrcc3, and Rad51d and reduced homology-directed DNA repair activity in culture (PMID: 37253112).
RAD51C T132I missense loss of function RAD51C T132I does not lie within any known functional domains of the Rad51c protein (UniProt.org). T132I results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C T132R missense loss of function RAD51C T132R lies within the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). T132R results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, decreased colony formation, reduced Rad51 foci formation, and decreased homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C T336P missense loss of function - predicted RAD51C T336P does not lie within any known functional domains of the Rad51c protein (UniProt.org). T336P retains binding with Rad51b and Xrcc3 (PMID: 36099300, PMID: 37253112), but results in variable interaction with Rad51d in a yeast assay (PMID: 36099300), demonstrates lack of binding to Rad51d and Xrcc2 and results in decreased Rad51c homology-directed repair (HDR) activity compared to wild-type Rad51c in culture (PMID: 37253112), and therefore, is predicted to lead to a loss of Rad51c protein function.
RAD51C T5M missense no effect - predicted RAD51C T5M lies within a region of the Rad51c protein required for Holliday junction resolution activity (UniProt.org). T5M maintains functional homology-directed DNA repair activity in cell culture reporter assays (PMID: 42625895, PMID: 37253112) and binding to Rad51d and Xrcc3 similar to wild-type Rad51c in a yeast assay (PMID: 42625895), and therefore, is predicted to have no effect on Rad51c protein function.
RAD51C T5R missense no effect - predicted RAD51C T5R lies within a region of the Rad51c protein required for Holliday junction resolution activity (UniProt.org). T5R maintains functional homology-directed DNA repair activity in a cell culture reporter assay (PMID: 37253112), and therefore, is predicted to have no effect on Rad51c protein function.
RAD51C V140E missense loss of function RAD51C V140E does not lie within any known functional domains of the Rad51c protein (UniProt.org). V140E results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, decreased Rad51 foci formation, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
RAD51C V156D missense loss of function RAD51C V156D does not lie within any known functional domains of the Rad51c protein (UniProt.org). V156D results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C L138F Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C L138F sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G130R osteosarcoma sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G130R sensitized RAD51C-null osteosarcoma cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell survival (PMID: 37253112). 37253112
RAD51C Q133E Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C Q133E sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C R237P Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C R237P sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C L27P Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C L27P sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C T132I Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C T132I sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C V140E Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C V140E sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C A279P Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C A279P sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C V156D Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C V156D sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G125V Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G125V sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G153D Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G153D sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C R168G Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C R168G sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C R312W Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C R312W sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G114V Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G114V sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C D108G Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C D108G sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C T132I Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C T132I sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G302V Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G302V sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C T336P Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C T336P sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G150E Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G150E sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C D348V Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C D348V sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C T132R Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C T132R sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C R168G osteosarcoma sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C R168G sensitized RAD51C-null osteosarcoma cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell survival (PMID: 37253112). 37253112
RAD51C G162E Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G162E sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G114V Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G114V sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G130R Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G130R sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C T102I Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C T102I sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C K131I Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C K131I sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G302V Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G302V sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G153D Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G153D sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C R168G Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C R168G sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C D348V Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C D348V sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G114R Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G114R sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G130R Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G130R sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C R312W Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C R312W sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G306R Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G306R sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C T132R Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C T132R sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C V156D Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C V156D sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C T336P Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C T336P sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C A279P Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C A279P sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C D159A Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C D159A sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C T132R osteosarcoma sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C T132R sensitized RAD51C-null osteosarcoma cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell survival (PMID: 37253112). 37253112
RAD51C L138F Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C L138F sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C D159Y Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C D159Y sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C C135Y Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C C135Y sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G125V Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G125V sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C S163R Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C S163R sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G150E Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G150E sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C T102I Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C T102I sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C L27P Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C L27P sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C S163R Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C S163R sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C D108G Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C D108G sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C D159Y Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C D159Y sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C D242N Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C D242N sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C A155E Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C A155E sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C D242N Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C D242N sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C Q133E Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C Q133E sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C V140E Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C V140E sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C D159A Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C D159A sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C K131I osteosarcoma sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C K131I sensitized RAD51C-null osteosarcoma cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell survival (PMID: 37253112). 37253112
RAD51C K131I Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C K131I sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G162E Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G162E sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C A155E Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C A155E sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C R237P Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C R237P sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112