Reference Detail

Ref Type

Journal Article

PMID

(33799733)

Authors

Sciot R

Title

MDM2 Amplified Sarcomas: A Literature Review.

Journal	Vol	Issue	Date	Pages	Journal Short Title
Diagnostics (Basel, Switzerland)	11	3	2021 Mar 11		Diagnostics (Basel)

URL

Abstract Text

Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53. Mutations of the tumor suppressor gene p53 represent the most frequent genetic change in human cancers. By overexpressing MDM2, cancer cells have another means to block p53. The sarcomas in which MDM2 amplification is a hallmark are well-differentiated liposarcoma/atypical lipomatous tumor, dedifferentiated liposarcoma, intimal sarcoma, and low-grade osteosarcoma. The purpose of this review is to summarize the typical clinical, histopathological, immunohistochemical, and genetic features of these tumors.

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Molecular Profile	Treatment Approach

Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role

Therapy Name	Drugs	Efficacy Evidence	Clinical Trials

Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description

Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance

Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
MDM2 amp	parosteal osteosarcoma	not applicable	N/A	Clinical Study	Diagnostic	MDM2 amplification aids in the diagnosis of parosteal osteosarcoma (PMID: 33799733, PMID: 24786129, PMID: 21336260, PMID: 20601938).	20601938 33799733 24786129 21336260
MDM2 amp	dedifferentiated liposarcoma	not applicable	N/A	Clinical Study	Diagnostic	MDM2 amplification aids in the diagnosis of dedifferentiated liposarcoma (PMID: 36674856, PMID: 35074968, PMID: 18500263, PMID: 33799733).	33799733 36674856 35074968 18500263
MDM2 amp	well-differentiated liposarcoma	not applicable	N/A	Clinical Study	Diagnostic	MDM2 amplification aids in the diagnosis of well-differentiated liposarcoma (PMID: 33799733, PMID: 34984861, PMID: 35074968, PMID: 36674856).	36674856 33799733 34984861 35074968