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Ref Type Journal Article
PMID (24786129)
Authors Hang JF, Chen PC
Title Parosteal osteosarcoma.
Journal Vol Issue Date Pages Journal Short Title
Archives of pathology & laboratory medicine 138 5 2014 May 694-9 Arch Pathol Lab Med
URL
Abstract Text Parosteal osteosarcoma is a rare malignant bone tumor arising from the bone cortical surface. It most commonly occurs in young women over the metaphyseal region, especially the long bones near the knee joint. Patients usually report a slow-growing mass for years. The tumor is characterized by its bland microscopic morphology, prone to be misdiagnosed as other benign tumors. In the absence of dedifferentiation, the prognosis is generally better than that of conventional osteosarcoma. Recent studies demonstrated distinctive cytogenetic abnormality resulting in amplification of the CDK4 and MDM2 genes, which may serve as markers for molecular diagnosis. In this article, we review the clinical, radiologic, and pathologic features of parosteal osteosarcoma and identify some diagnostic pitfalls, discuss the prognostic variables, and update recent molecular advances and their application in the diagnosis.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MDM2 amp parosteal osteosarcoma not applicable N/A Clinical Study Diagnostic MDM2 amplification aids in the diagnosis of parosteal osteosarcoma (PMID: 33799733, PMID: 24786129, PMID: 21336260, PMID: 20601938). 20601938 33799733 24786129 21336260