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Ref Type
PMID (38429896)
Authors Inoue T, Kunimasa K, Tamiya M, Kawamura T, Minami T, Nishino K
Title Exceptionally long-lasting response to dabrafenib plus trametinib treatment in a patient with lung adenocarcinoma harboring the BRAF V600E mutation with high expression of PD-L1: A case report.
Journal Vol Issue Date Pages Journal Short Title
Thoracic cancer 2024 Mar 01 Thorac Cancer
URL
Abstract Text We present a patient with lung adenocarcinoma showing high PD-L1 expression and BRAF V600E mutation, who achieved a remarkable long-term response to the combination therapy of dabrafenib and trametinib (DT treatment) after disease progression on immunotherapy. This case may provide an opportunity for clinicians to consider the order of administration of immunotherapy and molecular targeted therapy for BRAF V600E-positive lung cancer.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E CD274 over exp lung adenocarcinoma predicted - sensitive Dabrafenib + Trametinib Case Reports/Case Series Actionable In a clinical case study, second-line treatment with the combination of Tafinlar (dabrafenib) and Mekinist (trametinib) resulted in a clinical response lasting at least 5 years in a patient with lung adenocarcinoma harboring BRAF V600E and high CD274 (PD-L1) expression (TPS=100%) who did not respond to first-line Keytruda (pembrolizumab) (PMID: 38429896). 38429896