Reference Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Ref Type Journal Article
PMID (22146228)
Authors Bowles DW, Kessler ER, Jimeno A
Title Multi-targeted tyrosine kinase inhibitors in clinical development: focus on XL-184 (cabozantinib).
Journal Vol Issue Date Pages Journal Short Title
Drugs of today (Barcelona, Spain : 1998) 47 11 2011 Nov 857-68 Drugs Today (Barc)
URL
Abstract Text XL-184 (cabozantinib) is a novel, small-molecule, multitargeted receptor tyrosine kinase inhibitor with particular activity against hepatocyte growth factor receptor (tyrosine-protein kinase Met), vascular endothelial growth factor receptor 2 (VEGFR-2) and proto-oncogene tyrosine-protein kinase receptor Ret. There is ample evidence of Met, VEGFR-2 and Ret signaling in several tumor types. Preclinical data suggest that XL-184 has activity in tumors derived from both epithelial and mesenchymal origins. Phase I and II clinical studies support significant antitumor activity, particularly in medullary thyroid cancer and cancers metastatic to the bone. This review will evaluate XL-184's preclinical pharmacology, pharmacokinetics, drug interactions and clinical activity in phase I through phase III studies.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Treatment Approach
RET C515W RET Inhibitor
RET amp RET Inhibitor
RET K666N RET Inhibitor
RET T930P RET Inhibitor
RET E505_G506del RET Inhibitor
RET C634W RET Inhibitor
RET Y606C RET Inhibitor
RET E768D RET Inhibitor
RET I852M RET Inhibitor
RET C618F RET Inhibitor
RET R912P RET Inhibitor
RET E574D RET Inhibitor
RET C634F RET Inhibitor
RET C611W RET Inhibitor
RET C515S RET Inhibitor
RET D567N RET Inhibitor
RET V804M RET Inhibitor
RET C630R RET Inhibitor
RET E616Q RET Inhibitor
RET C618R RET Inhibitor
RET D631Y RET Inhibitor
RET S409Y RET Inhibitor
RET C620Y RET Inhibitor
RET C531R RET Inhibitor
RET D584N RET Inhibitor
RET C630F RET Inhibitor
RET act mut RET Inhibitor
RET T930K RET Inhibitor
RET A883F RET Inhibitor
RET C634R RET Inhibitor
RET C618Y RET Inhibitor
RET C634S RET Inhibitor
RET C611Y RET Inhibitor
RET M918T RET Inhibitor
RET E511K RET Inhibitor
RET C630Y RET Inhibitor
RET S891A RET Inhibitor
RET S904F RET Inhibitor
RET R833C RET Inhibitor
RET C618S RET Inhibitor
RET K666E RET Inhibitor
RET L633_C634dup RET Inhibitor
RET C634_R635insHELC RET Inhibitor
RET E805K RET Inhibitor
RET T636M RET Inhibitor
RET C620R RET Inhibitor
RET V804L RET Inhibitor
RET Y806C RET Inhibitor
RET G607C RET Inhibitor
RET S649L RET Inhibitor
RET A883T RET Inhibitor
RET C620S RET Inhibitor
RET C634L RET Inhibitor
RET D567Y RET Inhibitor
RET M848T RET Inhibitor
RET C618G RET Inhibitor
RET C634Y RET Inhibitor
RET C609R RET Inhibitor
RET M918V RET Inhibitor
RET R886W RET Inhibitor
RET C609S RET Inhibitor
RET V292M RET Inhibitor
RET C634G RET Inhibitor
RET E632_L633del RET Inhibitor
RET D898_E901del RET Inhibitor
RET A510V RET Inhibitor
RET C630S RET Inhibitor
RET C609Y RET Inhibitor
RET G533C RET Inhibitor
RET C630del RET Inhibitor
RET C630G RET Inhibitor
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References