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| NCT ID | NCT02617589 |
| Title | Study of Nivolumab Versus Temozolomide, Given With Radiation Therapy, for Newly-diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer) (CheckMate 498) |
| Acronym | CheckMate 498 |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Bristol-Myers Squibb |
| Indications | |
| Therapies | |
| Age Groups: | adult |
| Covered Countries | USA | SWE | POL | NOR | NLD | ITA | ISR | GBR | FRA | ESP | DNK | DEU | CHE | CAN | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294-3410 | United States | Details | |
| Local Institution - 0083 | Phoenix | Arizona | 85013 | United States | Details | |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | United States | Details | |
| Local Institution - 0019 | Los Angeles | California | 90095-1769 | United States | Details | |
| Sutter Institute For Medical Research | Sacramento | California | 95816 | United States | Details | |
| Sharp Memorial Hospital | San Diego | California | 92123 | United States | Details | |
| The Regents of the University of California, San Francisco | San Francisco | California | 94143-0372 | United States | Details | |
| Yale Cancer Center | New Haven | Connecticut | 06520 | United States | Details | |
| Georgetown University Medical Center | Washington | District of Columbia | 20007 | United States | Details | |
| University Of Miami Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | United States | Details | |
| Moffitt Cancer Center | Tampa | Florida | 33612 | United States | Details | |
| Emory University - Winship Cancer Institute | Atlanta | Georgia | 30322 | United States | Details | |
| The University Of Chicago | Chicago | Illinois | 60637 | United States | Details | |
| University Of Kansas Medical Center | Westwood | Kansas | 66205 | United States | Details | |
| Norton Cancer Institute | Louisville | Kentucky | 40202 | United States | Details | |
| Johns Hopkins University School Of Medicine | Baltimore | Maryland | 21287 | United States | Details | |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | United States | Details | |
| Massachusetts General Hospital | Boston | Massachusetts | 02215 | United States | Details | |
| Local Institution - 0006 | Detroit | Michigan | 48202 | United States | Details | |
| Washington University School OF Medicine-Siteman Cancer Center | Saint Louis | Missouri | 63110 | United States | Details | |
| JFK Medical Center | Edison | New Jersey | 08820 | United States | Details | |
| Local Institution - 0064 | Hackensack | New Jersey | 07601 | United States | Details | |
| Columbia University Medical Center (Cumc) | New York | New York | 10032 | United States | Details | |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States | Details | |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | United States | Details | |
| Preston Robert Tisch Brain Tumor Center at Duke University | Durham | North Carolina | 27710 | United States | Details | |
| Local Institution - 0010 | Cleveland | Ohio | 44195 | United States | Details | |
| Local Institution - 0095 | Columbus | Ohio | 43210 | United States | Details | |
| Local Institution - 0132 | Allentown | Pennsylvania | 18103 | United States | Details | |
| Local Institution - 0007 | Philadelphia | Pennsylvania | 19107 | United States | Details | |
| Medical University Of South Carolina | Charleston | South Carolina | 29425 | United States | Details | |
| Local Institution - 0090 | Chattanooga | Tennessee | 37404 | United States | Details | |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | United States | Details | |
| University Of Texas Southwestern Medical Center | Dallas | Texas | 75390-8852 | United States | Details | |
| University Of Texas Md Anderson Cancer Ctr | Houston | Texas | 77030 | United States | Details | |
| Local Institution - 0068 | Salt Lake City | Utah | 84112 | United States | Details | |
| Swedish Neuroscience Institute | Seattle | Washington | 98122 | United States | Details | |
| Royal North Shore Hospital | St. Leonards | New South Wales | 2065 | Australia | Details | |
| Local Institution - 0003 | Heidelberg | Victoria | 3084 | Australia | Details | |
| Local Institution - 0004 | Prahran | Victoria | 3181 | Australia | Details | |
| Local Institution - 0001 | Nedlands | Western Australia | 6009 | Australia | Details | |
| Local Institution - 0002 | New South Wales | 2170 | Australia | Details | ||
| Local Institution - 0061 | Linz | 4020 | Austria | Details | ||
| Local Institution - 0060 | Vienna | 1090 | Austria | Details | ||
| Universitair Ziekenhuis Brussel | Brussels | 1090 | Belgium | Details | ||
| Cliniques Universitaires Saint-Luc | Bruxelles | 1200 | Belgium | Details | ||
| Uz Leuven | Leuven | 3000 | Belgium | Details | ||
| BC Cancer - Vancouver | Vancouver | British Columbia | V5Z 4E6 | Canada | Details | |
| Princess Margaret Cancer Centre | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| Montreal Neurological Institute and Hospital | Montreal | Quebec | H3A 2B4 | Canada | Details | |
| Local Institution | Copenhagen | 2100 | Denmark | Details | ||
| Local Institution | Odense | 5000 | Denmark | Details | ||
| Local Institution - 0032 | Bron Cedex | 69677 | France | Details | ||
| Local Institution | Lille Cedex | 59037 | France | Details | ||
| Local Institution - 0024 | Marseille | 13005 | France | Details | ||
| Local Institution - 0101 | Nancy | 54035 | France | Details | ||
| Local Institution - 0038 | Paris cedex 13 | 75651 | France | Details | ||
| Local Institution - 0023 | Paris | 75010 | France | Details | ||
| Centre Eugene Marquis | Rennes | 35000 | France | Details | ||
| Local Institution - 0106 | Toulouse | 31100 | France | Details | ||
| Local Institution - 0051 | Bonn | 53105 | Germany | Details | ||
| Local Institution - 0072 | Erlangen | 91054 | Germany | Details | ||
| Local Institution - 0049 | Frankfurt am Main | 60528 | Germany | Details | ||
| Local Institution - 0073 | Freiburg | 79106 | Germany | Details | ||
| Local Institution - 0054 | Hamburg | 20246 | Germany | Details | ||
| Local Institution - 0052 | Heidelberg | 69120 | Germany | Details | ||
| Local Institution - 0139 | Koeln | 50937 | Germany | Details | ||
| Local Institution - 0050 | Muenster | 48149 | Germany | Details | ||
| Local Institution - 0138 | Munich | 81675 | Germany | Details | ||
| Local Institution - 0055 | Regensburg | 93053 | Germany | Details | ||
| Local Institution - 0056 | Tuebingen | 72076 | Germany | Details | ||
| Local Institution - 0096 | Petach Tikva | 49100 | Israel | Details | ||
| Local Institution - 0097 | Tel Aviv | 64239 | Israel | Details | ||
| Local Institution - 0076 | Bologna | 40139 | Italy | Details | ||
| Local Institution - 0079 | Milano | 20133 | Italy | Details | ||
| Local Institution - 0126 | Padova | 35128 | Italy | Details | ||
| Local Institution - 0135 | Rozzano (milano) | 20089 | Italy | Details | ||
| Local Institution - 0078 | Siena | 53100 | Italy | Details | ||
| Local Institution - 0077 | Torino | 10126 | Italy | Details | ||
| Local Institution - 0115 | Nagoya-shi | Aichi | 4668560 | Japan | Details | |
| Local Institution - 0125 | Chiba-shi | Chiba | 2608677 | Japan | Details | |
| Local Institution - 0123 | Hiroshima-Shi | Hiroshima | 7348551 | Japan | Details | |
| Local Institution - 0122 | Sapporo-shi | Hokkaido | 0608648 | Japan | Details | |
| Local Institution - 0129 | Kobe | Hyogo | 6500017 | Japan | Details | |
| Local Institution - 0111 | Tsukuba-shi | Ibaraki | 3058576 | Japan | Details | |
| Local Institution - 0121 | Kanazawa-shi | Ishikawa | 9200934 | Japan | Details | |
| Local Institution - 0131 | Kagoshima-shi | Kagoshima | 8908520 | Japan | Details | |
| Local Institution - 0133 | Sagamihara-shi | Kanagawa | 2520375 | Japan | Details | |
| Local Institution - 0119 | Kumamoto-shi | Kumamoto | 8608556 | Japan | Details | |
| Local Institution - 0117 | Kyoto-shi | Kyoto | 606-8507 | Japan | Details | |
| Local Institution - 0116 | Kyoto-shi | Kyoto | 6128555 | Japan | Details | |
| Local Institution - 0134 | Okayama-shi | Okayama | 7008558 | Japan | Details | |
| Local Institution | Hirakata-shi | Osaka | 5731191 | Japan | Details | |
| Local Institution - 0130 | Suita-shi | Osaka | 565-0871 | Japan | Details | |
| Local Institution - 0113 | Hidaka | Saitama | 350-1298 | Japan | Details | |
| Local Institution - 0128 | Bunkyo-ku | Tokyo | 1138655 | Japan | Details | |
| Local Institution - 0114 | Chuo-ku | Tokyo | 1040045 | Japan | Details | |
| Local Institution - 0118 | Mitaka-shi | Tokyo | 181-8611 | Japan | Details | |
| Local Institution - 0110 | Yamagata-shi | Yamagata | 9909585 | Japan | Details | |
| Local Institution - 0112 | Tokyo | 1628666 | Japan | Details | ||
| NKI AVL | Amsterdam | 1066 CX | Netherlands | Details | ||
| Universitair Medisch Centrum Groningen | Groningen | 9713 AP | Netherlands | Details | ||
| Erasmus Mc | Rotterdam | 3015 CE | Netherlands | Details | ||
| Local Institution - 0063 | Utrecht | 3584CX | Netherlands | Details | ||
| Local Institution | Oslo | 0379 | Norway | Details | ||
| Local Institution - 0080 | Gdansk | 80952 | Poland | Details | ||
| Local Institution - 0081 | Warszawa | 02-781 | Poland | Details | ||
| Local Institution - 0070 | Moscow | 105229 | Russian Federation | Details | ||
| Local Institution - 0105 | Moscow | 115478 | Russian Federation | Details | ||
| Local Institution | Badalona-Barcelona | 08916 | Spain | Details | ||
| Local Institution | Barcelona | 08035 | Spain | Details | ||
| Local Institution - 0028 | Barcelona | 08036 | Spain | Details | ||
| Local Institution - 0029 | Madrid | 28007 | Spain | Details | ||
| Local Institution | Madrid | 28041 | Spain | Details | ||
| Local Institution | Santiago De Compostela | 15706 | Spain | Details | ||
| Local Institution - 0025 | Valencia | 46014 | Spain | Details | ||
| Local Institution | Lund | 221 85 | Sweden | Details | ||
| Local Institution | Solna | 171 64 | Sweden | Details | ||
| Local Institution - 0059 | Geneve | 1211 | Switzerland | Details | ||
| Local Institution - 0057 | Lausanne | 1011 | Switzerland | Details | ||
| Local Institution - 0053 | Zuerich | 8091 | Switzerland | Details | ||
| University College Hospital | London | Greater London | NW1 2PG | United Kingdom | Details | |
| Christie Hospital Nhs Found. Trust | Manchester | Greater Manchester | M20 4BX | United Kingdom | Details | |
| Royal Marsden Hospital | Sutton | Surrey | SM2 5PT | United Kingdom | Details | |
| Beaston West of Scotland Cancer Centre | Glasgow | G12 0YN | United Kingdom | Details |