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| NCT ID | NCT02627963 |
| Title | A Study to Compare Tivozanib Hydrochloride to Sorafenib in Subjects With Refractory Advanced RCC |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | AVEO Pharmaceuticals, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | adult |
| Covered Countries | USA | POL | ITA | HUN | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BEL |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University Of UA Cancer Center(UACC)/DH-SJHMC | Phoenix | Arizona | 85004 | United States | Details | |
| Arizona Oncology Associates, PC - HAL | Phoenix | Arizona | 85016 | United States | Details | |
| Arizona Oncology - Phoenix - Deer Valley Women's Center Loca | Phoenix | Arizona | 85027 | United States | Details | |
| Arizona Oncology - Scottsdale | Scottsdale | Arizona | 85258 | United States | Details | |
| City of Hope Comprehensive Breast Cancer Center | Duarte | California | 91010 | United States | Details | |
| Long Beach Memorial Medical Center | Fountain Valley | California | 92708 | United States | Details | |
| Marin Cancer Care | Greenbrae | California | 94904 | United States | Details | |
| UCLA | Los Angeles | California | 90095 | United States | Details | |
| MedStar Georgetown University Hospital | Washington | District of Columbia | 20007 | United States | Details | |
| Mount Sinai Comprehensive Cancer Center | Miami Beach | Florida | 33140 | United States | Details | |
| University of Miami Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | United States | Details | |
| Loyola University Medical Center | Maywood | Illinois | 60153 | United States | Details | |
| Investigative Clinical Research of Indiana | Indianapolis | Indiana | 46260 | United States | Details | |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | United States | Details | |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | United States | Details | |
| Henry Ford Health System | Detroit | Michigan | 48202 | United States | Details | |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | United States | Details | |
| Midwest Cancer Center | Omaha | Nebraska | 68130 | United States | Details | |
| Urology Cancer Center, PC | Omaha | Nebraska | 68130 | United States | Details | |
| Comprehensive Cancer Center Of Nevada | Henderson | Nevada | 89052 | United States | Details | |
| Comprehensive Cancer Centers of Nevada | Henderson | Nevada | 89074 | United States | Details | |
| Comprehensive Cancer Center Of Nevada | Las Vegas | Nevada | 89128 | United States | Details | |
| Comprehensive Cancer Center of Nevada | Las Vegas | Nevada | 89148 | United States | Details | |
| Hackensack University Medical Center - John Theurer Cancer | Hackensack | New Jersey | 07601 | United States | Details | |
| New York Oncology Hematology, P.C. | Albany | New York | 12206 | United States | Details | |
| New York Oncology Hematology, PC | Albany | New York | 12208 | United States | Details | |
| Montefiore Medical Center | Bronx | New York | 10467 | United States | Details | |
| New York Oncology Hematology, P.C. | Clifton Park | New York | 12065 | United States | Details | |
| New York Presbyterian Hospital | New York | New York | 10021 | United States | Details | |
| Columbia University Medical Center - Herbert Irving Pavilion | New York | New York | 10032 | United States | Details | |
| University of Rochester Medical Center | Rochester | New York | 14642 | United States | Details | |
| Wake Forest University Baptist Medical Center (WFUBMC) | Winston-Salem | North Carolina | 27157 | United States | Details | |
| Cleveland Clinic | Cleveland | Ohio | 44195 | United States | Details | |
| Ohio Cancer Specialists | Mansfield | Ohio | 44906 | United States | Details | |
| North Coast Cancer Care, Inc | Sandusky | Ohio | 44870 | United States | Details | |
| Wooster Specialty and Surgery Center | Wooster | Ohio | 44691 | United States | Details | |
| St. Luke University Health Network | Easton | Pennsylvania | 18045 | United States | Details | |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | United States | Details | |
| University of Pittsburgh Medical Center (UPMC) | Pittsburgh | Pennsylvania | 15232 | United States | Details | |
| Texas Oncology - Austin Midtown | Austin | Texas | 78705 | United States | Details | |
| Texas Oncology-Central Austin Cancer Center | Austin | Texas | 78731 | United States | Details | |
| Texas Oncology - South Austin Cancer Center | Austin | Texas | 78745 | United States | Details | |
| Texas Oncology - Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | United States | Details | |
| Texas Oncology - Fort Worth 12th Ave | Fort Worth | Texas | 76104 | United States | Details | |
| Texas Oncology SW Fort Worth Cancer Center | Fort Worth | Texas | 76132 | United States | Details | |
| Arizona Oncology Associates, PC - HAL | Fort Worth | Texas | 76177 | United States | Details | |
| Comprehensive Cancer Centers of Nevada (CCCN) | Fort Worth | Texas | 76177 | United States | Details | |
| Comprehensive Cancer Centers of Nevada | Fort Worth | Texas | 76177 | United States | Details | |
| Nebraska Cancer Specialists (NCS) - Midwest Cancer Center | Fort Worth | Texas | 76177 | United States | Details | |
| Texas Oncology - El Paso Cancer Treatment Center | Fort Worth | Texas | 76177 | United States | Details | |
| Texas Oncology-El Paso Cancer Treatment Center | Fort Worth | Texas | 76177 | United States | Details | |
| Texas Oncology-Garland | Garland | Texas | 75042 | United States | Details | |
| Baylor College of Medicine - Baylor Clinic | Houston | Texas | 77030 | United States | Details | |
| Texas Oncology - Longview Cancer Center | Longview | Texas | 75601 | United States | Details | |
| Texas Oncology, P.A. | Plano | Texas | 75093 | United States | Details | |
| Texas Oncology - Tyler | Tyler | Texas | 75702 | United States | Details | |
| UZ Antwerpen | Edegem | Antwerpen | 2650 | Belgium | Details | |
| Institut Jules Bordet | Bruxelles | Brussels Capital Region | 1000 | Belgium | Details | |
| Grand Hôpital de Charleroi - Site Notre-Dame | Charleroi | Hainaut | 6000 | Belgium | Details | |
| CHU Ambroise Paré | Mons | Hainaut | 7000 | Belgium | Details | |
| Jessa Ziekenhuis - Campus Virga Jesse | Hasselt | Limburg | 3500 | Belgium | Details | |
| CHU Dinant Godinne UCL Namur | Yvoir | Namur | 5530 | Belgium | Details | |
| UZ Gent | Gent | Oost-Vlaanderen | 9000 | Belgium | Details | |
| AZ Sint-Jan Brugge - Oostende - Campus Sint-Jan | Brugge | West-Vlaanderen | 8000 | Belgium | Details | |
| British Columbia Cancer Agency (BCCA) | Vancouver | British Columbia | V5Z 4E6 | Canada | Details | |
| Dr. Leon Richard Oncology Centre | Moncton | New Brunswick | E1C 8X3 | Canada | Details | |
| London Health Sciences Center | London | Ontario | N6A 4L6 | Canada | Details | |
| Sunnybrook | Toronto | Ontario | M4N3M5 | Canada | Details | |
| Masarykuv onkologicky ustav | Brno | Brno-město | 656 53 | Czechia | Details | |
| FN Hradec Kralove | Hradec Kralove | Královéhradecký Kraj | 500 05 | Czechia | Details | |
| Fakultni nemocnice Olomouc | Olomouc | Olomoucký Kraj | 779 00 | Czechia | Details | |
| Fakultni nemocnice u sv. Anny v Brne | Brno | 656 91 | Czechia | Details | ||
| Fakultni nemocnice v Motole | Praha 5 | 150 06 | Czechia | Details | ||
| Herlev Hospital | Herlev | Capital | 2730 | Denmark | Details | |
| Aarhus Universitetshospital | Aarhus C | Central Jutland | 8000 | Denmark | Details | |
| Odense Universitetshospital | Odense | South Denmark | 5000 | Denmark | Details | |
| Hopital Saint-André | Bordeaux Cedex | Gironde | 33075 | France | Details | |
| CHRU de Tours - Hopital Bretonneau TOURS | Tours CEDEX 1 | Indre-et-Loire | 37000 | France | Details | |
| Institut de Cancerologie de la Loire | Saint-Priest-en-Jarez | Loire | 42271 | France | Details | |
| Institut de Cancérologie de l'Ouest Site Paul Papin | Angers | Maine-et-Loire | 49000 | France | Details | |
| Institut de cancérologie de Lorraine | Vandoeuvre Les Nancy | Meurthe-et-Moselle | 54519 | France | Details | |
| centre Oscar Lambret | Lille | Nord-Pas-de-Calais | 59020 | France | Details | |
| Clinique Victor Hugo | Le Mans | Pays-de-la-Loire | 72000 | France | Details | |
| Institut Paoli-Calmettes | Marseille Cedex 09 | 13273 | France | Details | ||
| Chu De Poitiers | Poitiers | 86021 | France | Details | ||
| ICO | Saint Herblain CEDEX | 44805 | France | Details | ||
| Institut Gustave Roussy | Villejuif | 94805 | France | Details | ||
| Universitätsklinikum Freiburg | Freiburg | Baden-Württemberg | 79106 | Germany | Details | |
| Univesitaetsklinik Heidelberg | Heidelberg | Baden-Württemberg | 69120 | Germany | Details | |
| Kliniken Nordoberpfalz AG, Klinikum Weiden | Weiden | Bayern | 92637 | Germany | Details | |
| Johann Wolfgang Goethe Universität | Frankfurt am Main | Hessen | 60590 | Germany | Details | |
| Evangelisches Krankenhaus Bielefeld | Bielefeld | Nordrhein-Westfalen | 33611 | Germany | Details | |
| SZB Study Center University Hospital Bonn | Bonn | Nordrhein-Westfalen | D-53127 | Germany | Details | |
| Uniklinik Köln Klinik und Poliklinik für Urologie | Köln | Nordrhein-Westfalen | 50937 | Germany | Details | |
| Universitätsklinikum des Saarlandes | Homburg | Saarland | 66421 | Germany | Details | |
| Universitätsklinikum Carl Gustav Carus | Dresden | Sachsen | 1307 | Germany | Details | |
| Jena University Hospital | Jena | Thüringen | 7743 | Germany | Details | |
| Universitätsklinikum Aachen | Aachen | 52074 | Germany | Details | ||
| Universitätsklinikum Hamburg-Eppendorf | Hamburg | 20246 | Germany | Details | ||
| Medizinische Hochschule Hannover | Hannover | 30625 | Germany | Details | ||
| Universitaetsklinikum Muenster | Muenster | 48149 | Germany | Details | ||
| Universität Tübingen | Tübingen | 72076 | Germany | Details | ||
| Pécsi Tudományegyetem Klinikai Központ | Pécs | Baranya | 7624 | Hungary | Details | |
| Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház | Miskolc | Borsod-Abaúj-Zemplén | 3526 | Hungary | Details | |
| Békés Megyei Pándy Kálmán Kórház | Gyula | Békés | 5700 | Hungary | Details | |
| Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpo | Szeged | Csongrád | 6720 | Hungary | Details | |
| Debreceni Egyetem Klinikai Központ | Debrecen | Hajdú-Bihar | 4032 | Hungary | Details | |
| Szent Margit Kórház | Budapest | 1032 | Hungary | Details | ||
| Magyar Honvédség Egészségügyi Központ | Budapest | 1062 | Hungary | Details | ||
| Semmelweis Egyetem | Budapest | 1082 | Hungary | Details | ||
| Semmelweis Egyetem | Budapest | 1083 | Hungary | Details | ||
| Országos Onkológiai Intézet | Budapest | 1122 | Hungary | Details | ||
| Egyesített Szent István és Szent László Kórház-Rendelőintéze | Budapest | H-1096 | Hungary | Details | ||
| Somogy Megyei Kaposi Mór Oktató Kórház | Kaposvár | 7400 | Hungary | Details | ||
| Markusovszky Egyetemi Oktatókórház | Szombathely | H-9700 | Hungary | Details | ||
| Zala Megyei Korhaz | Zalaegerszeg | H-8900 | Hungary | Details | ||
| Casa Sollievo della Sofferenza, IRCCS | San Giovanni Rotondo | Foggia | 71013 | Italy | Details | |
| Irccs Irst | Meldola | Forli | 47014 | Italy | Details | |
| Istituto Clinico Humanitas Rozzano, IRCCS | Rozzano | Milano | 20089 | Italy | Details | |
| Usl 7 Siena - Ospedale Alta Valdelsa ASL TOSCANA SUD-EST | Poggibonsi | Siena | 53100 | Italy | Details | |
| Istituto di Candiolo, IRCCS | Candiolo | Torino | 10060 | Italy | Details | |
| Ospedale S.Donato, AUSL 8 di Arezzo | Arezzo | 52100 | Italy | Details | ||
| Centro di Riferimento Oncologico IRCCS | Aviano | 33081 | Italy | Details | ||
| AO Spedali Civili di Brescia, PO Spedali Civili | Brescia | 25123 | Italy | Details | ||
| P.O. Ss. Annunziata | Chieti | 66013 | Italy | Details | ||
| ASST-Istituti Ospitalieri di Cremona, AO di Cremona | Cremona | 26100 | Italy | Details | ||
| AOU Careggi | Firenze | Italy | Details | |||
| IRCCS AOU San Martino-IST Istituto Nazionale per la Ricerca | Genova | 16132 | Italy | Details | ||
| Ospedale Vito Fazzi, ASL Lecce | Lecce | 73100 | Italy | Details | ||
| Fondazione IRCCS Istituto Nazionale dei Tumori | Milano | 20133 | Italy | Details | ||
| Ieo, Irccs | Milano | Italy | Details | |||
| AOU Policlinico di Modena | Modena | 41124 | Italy | Details | ||
| IRCCS Fondazione "Giovanni Pascale" | Napoli | 80131 | Italy | Details | ||
| Istituto Oncologico Veneto IOV-IRCCS | Padova | 35128 | Italy | Details | ||
| IRCCS Policlinico San Matteo | Pavia | 27100 | Italy | Details | ||
| PU Campus Bio-medico di Roma | Roma | 00128 | Italy | Details | ||
| Regina Elena, Istituto Nazionale dei Tumori, IFO, IRCCS | Roma | 144 | Italy | Details | ||
| Azienda Ospedaliera San Camillo Forlanini | Roma | 151 | Italy | Details | ||
| Azienda Ospedaliera S. Maria di Terni | Terni | 5100 | Italy | Details | ||
| Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina | Otwock | Mazowieckie | 05-400 | Poland | Details | |
| Centrum Onkologii - Instytut im. Marii Sklodowskiej - Curie | Warszawa | Mazowieckie | 02-781 | Poland | Details | |
| MAGODENT Sp. z o.o. Szpital Onkologiczno-Kardiologiczny | Warszawa | Mazowieckie | 04-125 | Poland | Details | |
| Szpital Specjalist w Brzozowie Podkarpacki Ośrodek Onkologiczny | Brzozow | 36-200 | Poland | Details | ||
| COPERNICUS Podmiot Leczn. Sp z o.o.,Wojew. Centrum Onkologii | Gdansk | 80-219 | Poland | Details | ||
| NZOZ Vesalius Sp. z o.o. | Krakow | 31-216 | Poland | Details | ||
| Uniwersytecki Szpital Kliniczny im. J. Mikulicza-Radeckiego | Wroclaw | 50-556 | Poland | Details | ||
| H.G.U. de Elche | Elche | Alicante | 03203 | Spain | Details | |
| H.U.Son Espases | Palma | Baleares | 07010 | Spain | Details | |
| Institut Català d'Oncologia-Hospital Universitari Germans Trias i Pujol | Badalona | Barcelona | 08916 | Spain | Details | |
| Institut Catalá d´Oncología (I.C.O.) | L'Hospitalet De Llobregat | Barcelona | 08907 | Spain | Details | |
| C.S. Parc Taulí | Sabadell | Barcelona | 08208 | Spain | Details | |
| H.U.F. Alcorcón | Alcorcón | Madrid | 28922 | Spain | Details | |
| H.U.P Hierro-Majadahonda | Majadahonda | Madrid | 28222 | Spain | Details | |
| C.H. de Navarra | Pamplona | Navarra | 31008 | Spain | Details | |
| H.del Mar | Barcelona | 08003 | Spain | Details | ||
| H.Sta.Creu i St.Pau | Barcelona | 08025 | Spain | Details | ||
| H.U.Vall d'Hebrón | Barcelona | 08035 | Spain | Details | ||
| H. Clinic de Barcelona | Barcelona | 08036 | Spain | Details | ||
| H.U. Reina Sofía | Córdoba | 14004 | Spain | Details | ||
| ICO-H.U.Dr.J.Trueta | Girona | 17007 | Spain | Details | ||
| C.H. de Jaén | Jaén | 23007 | Spain | Details | ||
| H.G.U. G. Marañón | Madrid | 28007 | Spain | Details | ||
| H.U. Infanta Leonor | Madrid | 28031 | Spain | Details | ||
| Hospital Universitario Ramón y Cajal | Madrid | 28034 | Spain | Details | ||
| H.C. S.Carlos | Madrid | 28040 | Spain | Details | ||
| H.U. F. Jiménez Díaz | Madrid | 28040 | Spain | Details | ||
| H.U. 12 de Octubre | Madrid | 28041 | Spain | Details | ||
| H.U. La Paz | Madrid | 28046 | Spain | Details | ||
| H. Madrid Norte Sanchinarro | Madrid | 28050 | Spain | Details | ||
| H.U. Virgen de la Victoria | Málaga | 29010 | Spain | Details | ||
| H.U.V. Macarena | Sevilla | 41009 | Spain | Details | ||
| F.I. Valenciano de Oncología | Valencia | 46009 | Spain | Details | ||
| H.U.P.La Fe | Valencia | 46026 | Spain | Details | ||
| H.U. Miguel Servet | Zaragoza | 50009 | Spain | Details | ||
| Addenbrooke's Hospital | Cambridge | Cambridgeshire | CB2 0QQ | United Kingdom | Details | |
| Beatson West Of Scotland Cancer Centre | Glasgow | Glasgow City | G12 0YN | United Kingdom | Details | |
| Cheltenham General Hospital | Cheltenham | Gloucestershire | GL53 7AN | United Kingdom | Details | |
| Southampton University Hospitals Nhs Trust | Southampton | Hampshire | SO16 6YD | United Kingdom | Details | |
| East Lancashire Hospitals NHS Trust | Blackburn | Lancashire | BB2 3HH | United Kingdom | Details | |
| Lancashire Teaching Hospitals NHS Foundation Trust | Preston | Lancashire | PR2 9HT | United Kingdom | Details | |
| Royal Stroke Center | Stoke-on-Trent | Staffordshire | ST4 6QG | United Kingdom | Details | |
| The Royal Marsden NHS Foundation Trust | Sutton | Surrey | SM2 5PT | United Kingdom | Details | |
| St James's University Hospital / Leeds Teaching Hospitals | Leeds | LS9 7TF | United Kingdom | Details | ||
| The Royal Marsden NHS Foundation Trust | London | SW36JJ | United Kingdom | Details | ||
| Charing Cross Hospital | London | W6 8RF | United Kingdom | Details | ||
| The Christie NHS Foundation Trust | Manchester | M20 4BX | United Kingdom | Details | ||
| Mount Vernon Cancer Care | Middlesex | HA6 2RN | United Kingdom | Details | ||
| Nottingham University Hospitals NHS Trust - City Hospital | Nottingham | NG5 1PB | United Kingdom | Details | ||
| Churchill Hospital [Oncology] | Oxford | OX3 7LJ | United Kingdom | Details | ||
| Singleton Hospital | Swansea | SA2 8QA | United Kingdom | Details | ||
| New Cross Hospital | Wolverhampton | WV10 0QP | United Kingdom | Details |