Therapy Detail
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| Therapy Name | Tivozanib |
| Synonyms | |
| Therapy Description |
Fotivda (tivozanib) inhibits VEGFR1-3, which may result in decreased tumor angiogenesis and proliferation and increased cell death (PMID: 23788831, PMID: 31810797, PMID: 32547647). Fotivda(tivozanib) is FDA approved for use in adult patients with relapsed or refractory advanced renal cell carcinoma who have received two or more prior systemic therapies (FDA.gov). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Tivozanib | Fotivda | AV-951|AV951|KIL-8951|KRN 951|KRN-951 | VEGFR Inhibitor (Pan) 36 | Fotivda (tivozanib) inhibits VEGFR1-3, which may result in decreased tumor angiogenesis and proliferation and increased cell death (PMID: 23788831, PMID: 31810797, PMID: 32547647). Fotivda(tivozanib) is FDA approved for use in adult patients with relapsed or refractory advanced renal cell carcinoma who have received two or more prior systemic therapies (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NRAS mutant | acute myeloid leukemia | predicted - resistant | Tivozanib | Preclinical - Patient cell culture | Actionable | In a preclinical study, NRAS mutations correlated with resistance to Fotivda (tivozanib) in patient-derived acute myeloid leukemia samples in an ex vivo assay (PMID: 30333627). | 30333627 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT01853644 | Phase II | Tivozanib | Tivozanib in Recurrent, Platinum-Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer | Completed | USA | 0 |
| NCT02627963 | Phase III | Sorafenib Tivozanib | A Study to Compare Tivozanib Hydrochloride to Sorafenib in Subjects With Refractory Advanced RCC | Completed | USA | POL | ITA | HUN | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BEL | 0 |
| NCT01835223 | Phase Ib/II | Tivozanib | Tivozanib in Treating Patients With Liver Cancer That is Metastatic or Cannot Be Removed by Surgery | Completed | USA | 0 |
| NCT01972516 | Phase II | Tivozanib | Tivozanib As Maintenance Therapy In GYN | Terminated | USA | 0 |
| NCT04987203 | Phase III | Nivolumab + Tivozanib Tivozanib | Study to Compare Tivozanib in Combination With Nivolumab to Tivozanib Monotherapy in Subjects With Renal Cell Carcinoma | Active, not recruiting | USA | POL | ITA | GBR | FRA | ESP | DEU | CZE | CAN | BRA | BEL | AUS | ARG | 3 |
| NCT04645160 | Phase Ib/II | Tivozanib | Phase I/II Study Evaluating Safety and Efficacy of Tivozanib (AV-951) in Cholangiocarcinoma | Recruiting | USA | 0 |
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