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| NCT ID | NCT03036488 |
| Title | Study of Pembrolizumab (MK-3475) Plus Chemotherapy vs Placebo Plus Chemotherapy as Neoadjuvant Therapy and Pembrolizumab vs Placebo as Adjuvant Therapy in Participants With Triple Negative Breast Cancer (TNBC) (MK-3475-522/KEYNOTE-522) |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | SWE | POL | ITA | ISR | IRL | GBR | FRA | ESP | DEU | CAN | BRA | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Virginia G. Piper Cancer Center Pharmacy - Scottsdale Healthcare ( Site 0089) | Scottsdale | Arizona | 85268 | United States | Details | |
| Arizona Oncology Associates PC- HOPE ( Site 8001) | Tucson | Arizona | 85711 | United States | Details | |
| Cedars Sinai Medical Center ( Site 0091) | Los Angeles | California | 90048 | United States | Details | |
| Pacific Cancer Care ( Site 0069) | Monterey | California | 93940 | United States | Details | |
| ICRI ( Site 0072) | Whittier | California | 90603 | United States | Details | |
| University of Colorado Cancer Center ( Site 0021) | Aurora | Colorado | 80045 | United States | Details | |
| Yale University School of Medicine ( Site 0054) | New Haven | Connecticut | 06510 | United States | Details | |
| Christiana Hospital ( Site 0029) | Newark | Delaware | 19713 | United States | Details | |
| Univ of Miami-Sylvester Comprehensive Cancer Center- Kendall satellite ( Site 0079) | Miami | Florida | 33176 | United States | Details | |
| The University of Chicago Medical Center ( Site 0047) | Chicago | Illinois | 60637-1447 | United States | Details | |
| North Shore University Health System ( Site 0081) | Evanston | Illinois | 60201 | United States | Details | |
| Orchard Healthcare Research Inc. ( Site 0049) | Skokie | Illinois | 60077 | United States | Details | |
| Goshen Center for Cancer Care ( Site 0010) | Goshen | Indiana | 46526 | United States | Details | |
| University of Iowa Hospital and Clinics ( Site 0038) | Iowa City | Iowa | 52242 | United States | Details | |
| New England Cancer Specialists ( Site 0005) | Scarborough | Maine | 04074 | United States | Details | |
| Henry Ford Hospital ( Site 0003) | Detroit | Michigan | 48202 | United States | Details | |
| Minnesota Oncology Hematology, PA ( Site 8013) | Minneapolis | Minnesota | 55404 | United States | Details | |
| Rutgers Cancer Institute of New Jersey ( Site 0073) | New Brunswick | New Jersey | 08903 | United States | Details | |
| Broome Oncology, LLC ( Site 8002) | Johnson City | New York | 13790 | United States | Details | |
| Nyack Hospital Infusion Center ( Site 0059) | Nyack | New York | 10960 | United States | Details | |
| TriHealth Cancer Institute-Good Samaritan Hospital ( Site 0044) | Cincinnati | Ohio | 45220 | United States | Details | |
| Oncology Hematology Care, Inc. ( Site 8011) | Cincinnati | Ohio | 45242 | United States | Details | |
| Providence Portland Medical Center ( Site 0052) | Portland | Oregon | 97213 | United States | Details | |
| Northwest Cancer Specialists, P.C. ( Site 8008) | Portland | Oregon | 97227 | United States | Details | |
| Magee - Women's Hospital ( Site 0011) | Pittsburgh | Pennsylvania | 15213 | United States | Details | |
| Rhode Island Hospital ( Site 0060) | Providence | Rhode Island | 02903 | United States | Details | |
| The West Clinic, P.C. ( Site 0078) | Germantown | Tennessee | 38138 | United States | Details | |
| Texas Oncology-Austin Central ( Site 8005) | Austin | Texas | 78731 | United States | Details | |
| Parkland Health and Hospital System ( Site 0093) | Dallas | Texas | 75235 | United States | Details | |
| Texas Oncology-Baylor Charles A. Sammons Cancer Center ( Site 8006) | Dallas | Texas | 75246 | United States | Details | |
| Simmons Cancer Center ( Site 0094) | Dallas | Texas | 75390-9015 | United States | Details | |
| UT Southwestern Medical Center ( Site 0030) | Dallas | Texas | 75390-9179 | United States | Details | |
| Moncrief Cancer Institute ( Site 0092) | Fort Worth | Texas | 76104 | United States | Details | |
| Texas Oncology-Memorial City ( Site 8003) | Houston | Texas | 77024 | United States | Details | |
| Houston Methodist Cancer Center ( Site 0013) | Houston | Texas | 77030 | United States | Details | |
| Texas Oncology- Plano East ( Site 8010) | Plano | Texas | 75075 | United States | Details | |
| Texas Oncology-San Antonio Northeast ( Site 8012) | San Antonio | Texas | 78217 | United States | Details | |
| Texas Oncology-Tyler ( Site 8007) | Tyler | Texas | 75702 | United States | Details | |
| University of Virginia ( Site 0022) | Charlottesville | Virginia | 22903 | United States | Details | |
| Virginia Cancer Specialists, PC ( Site 8009) | Fairfax | Virginia | 22031 | United States | Details | |
| Bon Secours Cancer Institute Medical Oncology at St. Mary's ( Site 0033) | Midlothian | Virginia | 23114 | United States | Details | |
| Peninsula Cancer Institute, LLC ( Site 0041) | Newport News | Virginia | 23601 | United States | Details | |
| Virginia Oncology Associates ( Site 8000) | Norfolk | Virginia | 23502 | United States | Details | |
| Kadlec Clinic Hematology and Oncology ( Site 0087) | Kennewick | Washington | 99336 | United States | Details | |
| Seattle Cancer Care Alliance ( Site 0068) | Seattle | Washington | 98109 | United States | Details | |
| Medical Oncology Associates (Summit Cancer Centers) ( Site 0014) | Spokane | Washington | 99208 | United States | Details | |
| YVMH dba Vrigina Mason Memorial/North Star Lodge Cancer Center ( Site 8004) | Yakima | Washington | 98902 | United States | Details | |
| Royal North Shore Hospital ( Site 2000) | Sydney | New South Wales | 2065 | Australia | Details | |
| Westmead Hospital ( Site 2002) | Sydney | New South Wales | 2145 | Australia | Details | |
| Royal Adelaide Hospital ( Site 2008) | Adelaide | South Australia | 5000 | Australia | Details | |
| Cabrini Health ( Site 2009) | East Malvern | Victoria | 3145 | Australia | Details | |
| Frankston Hospital ( Site 2010) | Franskton | 3199 | Australia | Details | ||
| Royal Brisbane and Women s Hospital ( Site 2003) | Herston | 4029 | Australia | Details | ||
| St John of God Subiaco Hospital ( Site 2006) | Perth | 6008 | Australia | Details | ||
| Hospital Nossa Senhora da Conceicao ( Site 0203) | Porto Alegre | Rio Grande Do Sul | 91350-200 | Brazil | Details | |
| UOPECCAN - Uniao Oeste Paranaense de Estudos e Combate ao Cancer ( Site 0206) | Cascavel | 85806-300 | Brazil | Details | ||
| Universidade de Caxias do Sul ( Site 0201) | Caxias do Sul | 95070-560 | Brazil | Details | ||
| Hospital Erasto Gaertner ( Site 0207) | Curitiba | 81520-060 | Brazil | Details | ||
| Instituto do Cancer do Ceara ( Site 0205) | Fortaleza | 60430-230 | Brazil | Details | ||
| Hospital Araujo Jorge ( Site 0204) | Goiania | 74605-070 | Brazil | Details | ||
| Hospital Sao Lucas da PUCRS ( Site 0200) | Porto Alegre | 90610-900 | Brazil | Details | ||
| Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto ( Site 0208) | Sao Jose do Rio Preto | 15090-000 | Brazil | Details | ||
| Instituto do Cancer de Sao Paulo - ICESP ( Site 0211) | Sao Paulo | 01246-000 | Brazil | Details | ||
| Tom Baker Cancer Centre ( Site 0105) | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| The Ottawa Hospital - Cancer Care ( Site 0100) | Ottawa | Ontario | K1H 8L6 | Canada | Details | |
| Princess Margaret Cancer Centre ( Site 0103) | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0106) | Montreal | Quebec | H2X 0C1 | Canada | Details | |
| Jewish General Hospital ( Site 0101) | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| CIUSSS de l'Estrie-CHUS ( Site 0102) | Sherbrooke | Quebec | J1H 5N4 | Canada | Details | |
| CHU de Quebec Universite Laval - Hopital du Saint-Sacrement ( Site 0104) | Quebec | G1S 4L8 | Canada | Details | ||
| Oncomedica S.A. ( Site 0404) | Monteria | Cordoba | 230002 | Colombia | Details | |
| Oncologos del Occidente S.A. ( Site 0405) | Pereira | Risaralda | 661002 | Colombia | Details | |
| Hospital Universitario San Ignacio ( Site 0401) | Bogota | 110231 | Colombia | Details | ||
| Instituto Nacional de Cancerologia [Bogota-Colombia] ( Site 0403) | Bogota | 110411 | Colombia | Details | ||
| Hemato Oncologos S.A. ( Site 0400) | Cali | 760001 | Colombia | Details | ||
| Instituto De Cancerologia S.A. ( Site 0406) | Medellin | 050024 | Colombia | Details | ||
| CHU Jean Minjoz ( Site 0917) | Besancon | 25000 | France | Details | ||
| Polyclinique Bordeaux Nord Aquitaine ( Site 0911) | Bordeaux | 33077 | France | Details | ||
| Centre Francois Baclesse ( Site 0907) | Caen | 14000 | France | Details | ||
| Centre Jean Perrin ( Site 0903) | Clermont-Ferrand Cedex 01 | 63001 | France | Details | ||
| Clinique Victor Hugo ( Site 0901) | Le Mans | 72015 | France | Details | ||
| Hopital prive du Confluent ( Site 0902) | Nantes | 44277 | France | Details | ||
| Institut Curie ( Site 0909) | Paris | 75005 | France | Details | ||
| Hopital Saint Louis ( Site 0908) | Paris | 75010 | France | Details | ||
| Hopital Diaconesses Croix Saint Simon ( Site 0905) | Paris | 75020 | France | Details | ||
| CHU de la Miletrie Poitiers ( Site 0913) | Poitiers | 86021 | France | Details | ||
| Institut Claudius Regaud IUCT Oncopole ( Site 0914) | Toulouse Cedex 9 | 31059 | France | Details | ||
| HELIOS Klinikum Berlin-Buch ( Site 1005) | Berlin | 13125 | Germany | Details | ||
| Gynaekologisches Zentrum ( Site 1004) | Bonn | 53111 | Germany | Details | ||
| Universitaetsklinikum Erlangen ( Site 1001) | Erlangen | 91054 | Germany | Details | ||
| Kliniken Essen Mitte ( Site 1012) | Essen | 45136 | Germany | Details | ||
| Universitaetsklinik und Poliklinik Halle/Saale ( Site 1008) | Halle | 06120 | Germany | Details | ||
| Universitaetsklinikum Hamburg-Eppendorf ( Site 1007) | Hamburg | 20246 | Germany | Details | ||
| Klinikum der Universit. Muenchen ( Site 1002) | Muenchen | 80337 | Germany | Details | ||
| Caritasklinik St. Theresia ( Site 1011) | Saarbruecken | 66113 | Germany | Details | ||
| Universitaets-Frauenklinik Tuebingen ( Site 1003) | Tubingen | 72076 | Germany | Details | ||
| Bon Secours Hospital ( Site 1551) | Cork | T12 DV56 | Ireland | Details | ||
| St Vincents University Hospital ( Site 1550) | Dublin | D04 T6F4 | Ireland | Details | ||
| Oncology institute ( Site 1601) | Beer Sheva | 8410101 | Israel | Details | ||
| Assaf Harofeh MC ( Site 1605) | Beer Yaakov-Zerifin | 7030001 | Israel | Details | ||
| Hadassah Ein Karem - Sharett Institute of Oncology ( Site 1600) | Jerusalem | 9112001 | Israel | Details | ||
| Rabin-Medical Center ( Site 1604) | Petah Tikva | 4941492 | Israel | Details | ||
| Sheba Medical Center ( Site 1602) | Ramat-Gan | 5265601 | Israel | Details | ||
| Sourasky Medical Center ( Site 1603) | Tel Aviv | 6423906 | Israel | Details | ||
| Istituto Scientifico Romagnolo per Studio e Cura Tumori IRST ( Site 1101) | Meldola | FC | 47014 | Italy | Details | |
| Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia ( Site 1103) | Brescia | 25100 | Italy | Details | ||
| Ospedale San Luca, AZIENDA USL2 TOSCANA NORD OVEST ( Site 1105) | Lucca | 55100 | Italy | Details | ||
| Ospedale Civile di Macerata ( Site 1104) | Macerata | 62100 | Italy | Details | ||
| Istituto Europeo di Oncologia ( Site 1106) | Milano | 20141 | Italy | Details | ||
| Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1102) | Napoli | 80131 | Italy | Details | ||
| Aichi Cancer Center Hospital ( Site 2502) | Nagoya | Aichi | 464-8681 | Japan | Details | |
| National Cancer Center Hospital East ( Site 2518) | Kashiwa | Chiba | 277-8577 | Japan | Details | |
| National Hospital Organization Hokkaido Cancer Center ( Site 2512) | Sapporo | Hokkaido | 003-0804 | Japan | Details | |
| Hyogo College of Medicine Hospital ( Site 2506) | Nishinomiya | Hyogo | 663-8501 | Japan | Details | |
| Tokai University Hospital ( Site 2517) | Isehara | Kanagawa | 259-1193 | Japan | Details | |
| St. Marianna University School of Medicine Hospital ( Site 2516) | Kawasaki | Kanagawa | 216-8511 | Japan | Details | |
| Kindai University Hospital ( Site 2507) | Osakasayama | Osaka | 589-8511 | Japan | Details | |
| Saitama Medical University International Medical Center ( Site 2513) | Hidaka | Saitama | 350-1298 | Japan | Details | |
| Saitama Cancer Center ( Site 2510) | Kitaadachi-gun | Saitama | 362-0806 | Japan | Details | |
| Shizuoka Cancer Center Hospital and Research Institute ( Site 2514) | Sunto-gun | Shizuoka | 411-8777 | Japan | Details | |
| Chiba Cancer Center ( Site 2519) | Chiba | 260-8717 | Japan | Details | ||
| Hiroshima City Hiroshima Citizens Hospital ( Site 2501) | Hiroshima | 730-8518 | Japan | Details | ||
| Social medical corporation Hakuaikai Sagara Hospital ( Site 2508) | Kagoshima | 892-0833 | Japan | Details | ||
| Kumamoto University Hospital ( Site 2515) | Kumamoto | 860-8556 | Japan | Details | ||
| National Hospital Organization Osaka National Hospital ( Site 2505) | Osaka | 540-0006 | Japan | Details | ||
| National Cancer Center Hospital ( Site 2500) | Tokyo | 104-0045 | Japan | Details | ||
| St.Luke's International Hospital ( Site 2511) | Tokyo | 104-8560 | Japan | Details | ||
| Toranomon Hospital ( Site 2503) | Tokyo | 105-8470 | Japan | Details | ||
| The Cancer Institute Hospital of JFCR ( Site 2509) | Tokyo | 135-8550 | Japan | Details | ||
| Seoul National University Hospital ( Site 2101) | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital Yonsei University Health System ( Site 2100) | Seoul | 03722 | Korea, Republic of | Details | ||
| Asan Medical Center ( Site 2102) | Seoul | 05505 | Korea, Republic of | Details | ||
| Samsung Medical Center ( Site 2103) | Seoul | 06351 | Korea, Republic of | Details | ||
| Mazowiecki Szpital Onkologiczny ( Site 1713) | Wieliszew | Mazowieckie | 05-135 | Poland | Details | |
| Centrum Onkologii Instytut im. Marii Skłodowskiej Curie ( Site 1717) | Gliwice | Slaskie | 44-101 | Poland | Details | |
| Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1708) | Bydgoszcz | 85-796 | Poland | Details | ||
| Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1712) | Bydgoszcz | 85-796 | Poland | Details | ||
| Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 1701) | Gdynia | 81-519 | Poland | Details | ||
| Centrum Onkologii Instytut im. Marii Sklodowskiej Curie ( Site 1719) | Krakow | 31-115 | Poland | Details | ||
| Centrum Onkologii Ziemi Lubelskiej im. sw. Jana z Dukli ( Site 1700) | Lublin | 20-090 | Poland | Details | ||
| Dolnoslaskie Centrum Onkologii. ( Site 1702) | Wroclaw | 53-413 | Poland | Details | ||
| Fundacao Champalimaud ( Site 2444) | Lisboa | 1400-038 | Portugal | Details | ||
| Hospital de Santa Maria, E.P.E. ( Site 2445) | Lisboa | 1600-190 | Portugal | Details | ||
| Instituto Portugues de Oncologia Do Porto Francisco Gentil E.P.E. ( Site 2446) | Porto | 4200-072 | Portugal | Details | ||
| Arkhangelsk Clinical Oncological Dispensary ( Site 1810) | Arkhangelsk | 163045 | Russian Federation | Details | ||
| Chelyabinsk Regional Clinical Oncological Dispensary ( Site 1805) | Chelyabinsk | 454087 | Russian Federation | Details | ||
| Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1806) | Kazan | 420029 | Russian Federation | Details | ||
| Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 1801) | Moscow | 115478 | Russian Federation | Details | ||
| GBU RO Regional Clinical Oncological Dispensary ( Site 1808) | Ryazan | 390046 | Russian Federation | Details | ||
| Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1803) | Saint Petersburg | 197758 | Russian Federation | Details | ||
| Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1804) | Ufa | 450054 | Russian Federation | Details | ||
| National Cancer Centre Singapore ( Site 2600) | Singapore | 169610 | Singapore | Details | ||
| ICO L Hospitalet ( Site 1305) | Hospitalet de Llobregat | Barcelona | 08908 | Spain | Details | |
| Hospital Quiron de Madrid ( Site 1303) | Pozuelo de Alarcon | Madrid | 28223 | Spain | Details | |
| Hospital del Mar ( Site 1306) | Barcelona | 08003 | Spain | Details | ||
| Instituto Oncologico Baselga.Hospital Quiron. ( Site 1312) | Barcelona | 08023 | Spain | Details | ||
| Hospital General Universitari Vall d Hebron ( Site 1301) | Barcelona | 08035 | Spain | Details | ||
| Hospital Universitario Reina Sofia ( Site 1304) | Cordoba | 14004 | Spain | Details | ||
| Hospital Universitario Ramon y Cajal ( Site 1300) | Madrid | 28034 | Spain | Details | ||
| Complejo Hospitalario Universitario de Santiago ( Site 1308) | Santiago de Compostela | 15706 | Spain | Details | ||
| Hospital Universitario Virgen del Rocio ( Site 1314) | Sevilla | 41013 | Spain | Details | ||
| Hospital Clinico Univ de Valencia ( Site 1313) | Valencia | 46011 | Spain | Details | ||
| Linkopings Universitetssjukhus ( Site 1402) | Linkoping | 581 85 | Sweden | Details | ||
| Karolinska Universitetssjukhuset Solna ( Site 1404) | Solna | 171 64 | Sweden | Details | ||
| Norrlands Universitetssjukhus ( Site 1401) | Umea | 901 85 | Sweden | Details | ||
| Akademiska Sjukhuset ( Site 1403) | Uppsala | 751 85 | Sweden | Details | ||
| Taipei Veterans General Hospital ( Site 2302) | Taipei | Beitou | 11217 | Taiwan | Details | |
| National Cheng Kung University Hospital ( Site 2305) | Tainan | 704 | Taiwan | Details | ||
| National Taiwan University Hospital ( Site 2301) | Taipei | 100 | Taiwan | Details | ||
| MacKay Memorial Hospital ( Site 2303) | Taipei | 105 | Taiwan | Details | ||
| Koo Foundation Sun Yat-Sen Cancer Center ( Site 2304) | Taipei | 11259 | Taiwan | Details | ||
| Linkou Chang Gung Memorial Hospital ( Site 2300) | Taoyuan | 333 | Taiwan | Details | ||
| Samsun Ondokuz Mayıs Universitesi Tıp Fakultesi Hastanesi ( Site 1910) | Samsun | Atakum | 55280 | Turkey | Details | |
| Adana Acıbadem Hospital Department of Medical Oncology ( Site 1906) | Adana | 01130 | Turkey | Details | ||
| Baskent Unıversity Adana Kısla Hospital ( Site 1903) | Adana | 01250 | Turkey | Details | ||
| Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1912) | Ankara | 06100 | Turkey | Details | ||
| Abdurrahman Yurtaslan Oncology Training and Research Hospital ( Site 1909) | Ankara | 06200 | Turkey | Details | ||
| Ozel Medicana International Ankara Hastanesi ( Site 1915) | Ankara | 06510 | Turkey | Details | ||
| Antalya Memorial Hospital Department of Medical Oncology ( Site 1908) | Antalya | 07020 | Turkey | Details | ||
| Trakya University Medical Faculty Balkan Oncology Hospital ( Site 1901) | Edirne | 22030 | Turkey | Details | ||
| Acibadem Altunizade Hastanesi ( Site 1900) | Istambul | 34662 | Turkey | Details | ||
| İstanbul University Cerrahpaşa Medical Faculty ( Site 1904) | Istanbul | 34098 | Turkey | Details | ||
| Amerikan Hospital Medical ( Site 1902) | Istanbul | 34365 | Turkey | Details | ||
| Memorial Sisli Hastanesi ( Site 1913) | Istanbul | 34384 | Turkey | Details | ||
| Ege University Medical Faculty Tulay Aktas Oncology Hospital ( Site 1905) | Izmir | 35040 | Turkey | Details | ||
| Izmir Medical Park Hospital Department of Medical Oncology ( Site 1907) | Izmir | 35575 | Turkey | Details | ||
| Colchester General Hospital ( Site 1508) | Colchester | Essex | CO4 5JL | United Kingdom | Details | |
| Barts Cancer Institute ( Site 1500) | London | EC1M 6BQ | United Kingdom | Details | ||
| St George s Hospital ( Site 1516) | London | SW17 0QT | United Kingdom | Details | ||
| Maidstone Hospital ( Site 1511) | Maidstone | ME16 9QQ | United Kingdom | Details | ||
| The James Cook University Hospital ( Site 1515) | Middlesbrough | TS4 3BW | United Kingdom | Details | ||
| Nottingham University Hospitals NHS Trust ( Site 1505) | Nottingham | NG5 1PB | United Kingdom | Details | ||
| Royal Cornwall Hospitals NHS Trust ( Site 1504) | Truro | TR1 3LJ | United Kingdom | Details |