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| NCT ID | NCT03040999 |
| Title | Study of Pembrolizumab (MK-3475) or Placebo With Chemoradiation in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-412/KEYNOTE-412) |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | POL | NZL | NLD | ITA | ISR | GBR | FRA | ESP | DEU | CZE | CAN | BRA | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| UCLA Medical Center ( Site 0273) | Los Angeles | California | 90095 | United States | Details | |
| University of California San Francisco ( Site 0274) | San Francisco | California | 94115 | United States | Details | |
| St. Joseph Heritage Healthcare ( Site 0254) | Santa Rosa | California | 95403 | United States | Details | |
| Smilow Cancer Hospital at Yale New Haven ( Site 0256) | New Haven | Connecticut | 06510 | United States | Details | |
| Rush University Medical Center ( Site 0260) | Chicago | Illinois | 60612 | United States | Details | |
| Indiana University ( Site 0264) | Indianapolis | Indiana | 46202 | United States | Details | |
| Mary Bird Perkins Cancer Center at St. Tammany Parish Hospital ( Site 0281) | Baton Rouge | Louisiana | 70809 | United States | Details | |
| University of Massachusetts Memorial Medical Center ( Site 0285) | Worcester | Massachusetts | 01655 | United States | Details | |
| University of Michigan Hospital and Health Systems ( Site 0267) | Ann Arbor | Michigan | 48109 | United States | Details | |
| Barbara Ann Karmanos Cancer Institute ( Site 0272) | Detroit | Michigan | 48201 | United States | Details | |
| Mercy Clinic Cancer and Hematology - Chub O'Reilly Cancer Center ( Site 0290) | Springfield | Missouri | 65804 | United States | Details | |
| St. Vincent Healthcare Frontier Cancer Center ( Site 0286) | Billings | Montana | 59102 | United States | Details | |
| Comprehensive Cancer Centers of Nevada ( Site 8004) | Las Vegas | Nevada | 89169 | United States | Details | |
| University of Rochester - James P. Wilmot Cancer Center ( Site 0255) | Rochester | New York | 14642 | United States | Details | |
| Oncology Hematology Care, Inc. ( Site 8003) | Cincinnati | Ohio | 45242 | United States | Details | |
| Willamette Valley Cancer Institute and Research Center ( Site 8000) | Eugene | Oregon | 97401 | United States | Details | |
| St. Luke's Cancer Center - Anderson ( Site 0251) | Easton | Pennsylvania | 18045 | United States | Details | |
| St. Francis Hospital Cancer Center ( Site 1461) | Greenville | South Carolina | 29607 | United States | Details | |
| Texas Oncology-Arlington North ( Site 8005) | Arlington | Texas | 76014 | United States | Details | |
| Texas Oncology-Austin Central ( Site 8002) | Austin | Texas | 78731 | United States | Details | |
| Texas Oncology PA ( Site 8001) | Longview | Texas | 75601 | United States | Details | |
| University of Virginia Health System ( Site 0261) | Charlottesville | Virginia | 22908 | United States | Details | |
| Seattle Cancer Care Alliance/Univ of Washington Medical Center ( Site 0269) | Seattle | Washington | 98109 | United States | Details | |
| Medical Oncology Associates (Summit Cancer Centers) ( Site 0257) | Spokane | Washington | 99208 | United States | Details | |
| Liverpool Hospital ( Site 0301) | Liverpool | New South Wales (Australia) | 2170 | Australia | Details | |
| Blacktown Hospital Western Sydney Local Health District ( Site 0304) | Blacktown | New South Wales | 2148 | Australia | Details | |
| Princess Alexandra Hospital ( Site 0305) | Brisbane | Queensland | 4102 | Australia | Details | |
| Royal Brisbane and Women s Hospital ( Site 0302) | Herston | Queensland | 4029 | Australia | Details | |
| Royal Adelaide Hospital ( Site 0303) | Adelaide | South Australia | 5000 | Australia | Details | |
| Peter MacCallum Cancer Centre ( Site 0300) | Melbourne | Victoria | 3000 | Australia | Details | |
| Landeskrankenhaus - Universitatsklinikum Graz ( Site 0601) | Graz | 8036 | Austria | Details | ||
| Krankenhaus der Barmherzigen Schwestern Linz ( Site 0603) | Linz | 4010 | Austria | Details | ||
| Landeskrankenhaus Salzburg ( Site 0600) | Salzburg | 5020 | Austria | Details | ||
| Allgemeines Krankenhaus der Stadt Wien ( Site 0602) | Vienna/Wien | 1090 | Austria | Details | ||
| Cliniques Universitaires Saint Luc - Bruxelles ( Site 0651) | Brussels | 1200 | Belgium | Details | ||
| UZ Gent ( Site 0650) | Gent | 9000 | Belgium | Details | ||
| UZ Leuven Campus Gasthuisberg ( Site 0652) | Leuven | 3000 | Belgium | Details | ||
| C.H.U. Sart Tilman-Service d'Oncologie Medicale ( Site 0654) | Liege | 4000 | Belgium | Details | ||
| Clinique et Maternite Sainte-Elisabeth ( Site 0653) | Namur | 5000 | Belgium | Details | ||
| Hospital Santa Izabel - Santa Casa de Misericordia da Bahia ( Site 0006) | Salvador | Bahia | 40050-410 | Brazil | Details | |
| Centro Regional Integrado de Oncologia ( Site 0002) | Fortaleza | Ceara | 60336-045 | Brazil | Details | |
| Liga Norte Riograndense Contra o Cancer ( Site 0005) | Natal | Rio Grande Do Norte | 59075-740 | Brazil | Details | |
| Hospital Nossa Senhora da Conceicao ( Site 0001) | Porto Alegre | Rio Grande Do Sul | 91350-200 | Brazil | Details | |
| Hospital de Clinicas de Porto Alegre ( Site 0011) | Porto Alegre | RS | 90035-903 | Brazil | Details | |
| Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 0003) | Barretos | Sao Paulo | 14784-400 | Brazil | Details | |
| Instituto do Cancer de Sao Paulo - ICESP ( Site 0004) | Sao Paulo | SP | 01246-000 | Brazil | Details | |
| Hospital das Clinicas da FMUSP de Ribeirao Preto ( Site 0008) | Ribeirao Preto | 14048-900 | Brazil | Details | ||
| Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0010) | Rio de Janeiro | 20230-130 | Brazil | Details | ||
| Tom Baker Cancer Centre ( Site 0063) | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| Cross Cancer Institute ( Site 0064) | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| Juravinski Cancer Centre ( Site 0062) | Hamilton | Ontario | L8V 5C2 | Canada | Details | |
| London Health Sciences Centre ( Site 0055) | London | Ontario | N6A 4L6 | Canada | Details | |
| The Ottawa Hospital - Cancer Care ( Site 0052) | Ottawa | Ontario | K1H 8L6 | Canada | Details | |
| Princess Margaret Cancer Centre ( Site 0051) | Toronto | Ontario | M5G 1X5 | Canada | Details | |
| McGill University Health Centre ( Site 0061) | Montreal | Quebec | H4A 3J1 | Canada | Details | |
| CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0057) | Sherbrooke | Quebec | J1H 5N4 | Canada | Details | |
| Hospital Pablo Tobon Uribe ( Site 0151) | Medellin | Antioquia | 050034 | Colombia | Details | |
| Fundacion Valle del Lili ( Site 0150) | Cali | Valle Del Cauca | 760032 | Colombia | Details | |
| Centro Medico Imbanaco de Cali S.A ( Site 0156) | Cali | Valle Del Cauca | 760042 | Colombia | Details | |
| Centro de Investigacion Clinica del Country ( Site 0155) | Bogota | 110221 | Colombia | Details | ||
| FN Brno. ( Site 0703) | Brno | 625 00 | Czechia | Details | ||
| Fakultni Nemocnice Hradec Kralove ( Site 0705) | Hradec Kralove | 500 05 | Czechia | Details | ||
| Fakultni nemocnice Olomouc ( Site 0701) | Olomouc | 775 20 | Czechia | Details | ||
| Fakultni nemocnice Ostrava ( Site 0702) | Ostrava | 708 52 | Czechia | Details | ||
| Nemocnice Na Bulovce ( Site 0700) | Praha 8 | 180 81 | Czechia | Details | ||
| 2. LF UK a FN Motol ( Site 0704) | Praha | 150 06 | Czechia | Details | ||
| Centre Jean Bernard Laboratoire Mahe Meziani ( Site 0760) | Le Mans | 72000 | France | Details | ||
| Clinique Francois Chenieux ( Site 0757) | Limoges | 87039 | France | Details | ||
| Institut Claudius Regaud ( Site 0754) | Toulouse Cedex 09 | 31059 | France | Details | ||
| Institut De Cancerologie De Lorraine ( Site 0758) | Vandoeuvre les Nancy | 54500 | France | Details | ||
| Institut Gustave Roussy ( Site 0759) | Villejuif | 94805 | France | Details | ||
| Universitätsklinikum Erlangen ( Site 0801) | Erlangen | 91054 | Germany | Details | ||
| SRH Waldklinikum Gera GmbH ( Site 0802) | Gera | 07548 | Germany | Details | ||
| Universitares Cancer Center Hamburg - UCCH ( Site 0811) | Hamburg | 20246 | Germany | Details | ||
| Medizinische Hochschule Hannover ( Site 0807) | Hannover | 30325 | Germany | Details | ||
| Universitaetsklinikum Schleswig-Holstein-Campus Luebeck ( Site 0803) | Luebeck | 23538 | Germany | Details | ||
| Klinikum der Universitaet Munchen ( Site 0810) | Munchen | 81377 | Germany | Details | ||
| Universitaetsklinik Ulm ( Site 0804) | Ulm | 89075 | Germany | Details | ||
| Rambam MC ( Site 0903) | Haifa | 3109601 | Israel | Details | ||
| Hadassah Ein Karem Jerusalem ( Site 0902) | Jerusalem | 9112001 | Israel | Details | ||
| Rabin Medical Center ( Site 0904) | Petah Tikva | 4941492 | Israel | Details | ||
| Sheba MC ( Site 0901) | Ramat Gan | 5265601 | Israel | Details | ||
| Tel Aviv Sourasky Medical Center ( Site 0900) | Tel Aviv | 6423906 | Israel | Details | ||
| Azienda Ospedaliero Universitaria di Modena Policlinico ( Site 0954) | Modena | MO | 41124 | Italy | Details | |
| Azienda Ospedaliero Universitaria Careggi ( Site 0955) | Firenze | 50134 | Italy | Details | ||
| Istituto Nazionale Tumori ( Site 0950) | Milano | 20133 | Italy | Details | ||
| Istituto Europeo di Oncologia ( Site 0953) | Milano | 20141 | Italy | Details | ||
| Azienda Ospedaliera San Paolo ( Site 0952) | Milano | 20142 | Italy | Details | ||
| Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 0951) | Napoli | 80121 | Italy | Details | ||
| Istituto Oncologico Veneto ( Site 0957) | Padova | 35128 | Italy | Details | ||
| Fondazione IRCCS - Policlinico San Matteo ( Site 0960) | Pavia | 27100 | Italy | Details | ||
| National Cancer Center Hospital East ( Site 0350) | Kashiwa | Chiba | 277-8577 | Japan | Details | |
| Hokkaido University Hospital ( Site 0351) | Sapporo | Hokkaido | 060-8648 | Japan | Details | |
| Hyogo Cancer Center ( Site 0354) | Akashi | Hyogo | 673-8558 | Japan | Details | |
| Kagawa University Hospital ( Site 0359) | Kita-gun | Kagawa | 761-0793 | Japan | Details | |
| Miyagi Cancer Center ( Site 0353) | Natori | Miyagi | 981-1293 | Japan | Details | |
| Chiba Cancer Center ( Site 0358) | Chiba | 260-8717 | Japan | Details | ||
| Hiroshima University Hospital ( Site 0352) | Hiroshima | 734-8551 | Japan | Details | ||
| Osaka International Cancer Institute ( Site 0355) | Osaka | 541-8567 | Japan | Details | ||
| Medical Hospital, Tokyo Medical And Dental University ( Site 0356) | Tokyo | 113-8519 | Japan | Details | ||
| The Cancer Institute Hospital of JFCR ( Site 0357) | Tokyo | 135-8550 | Japan | Details | ||
| Chungbuk National University Hospital ( Site 0454) | Cheongju si | Chungcheongbuk Do | 28644 | Korea, Republic of | Details | |
| Seoul National University Bundang Hospital ( Site 0453) | Seongnam-si | Gyeonggi-do | 13620 | Korea, Republic of | Details | |
| Chungnam National University Hospital ( Site 0455) | Daejeon | 35015 | Korea, Republic of | Details | ||
| Severance Hospital Yonsei University Health System ( Site 0452) | Seoul | 03722 | Korea, Republic of | Details | ||
| Samsung Medical Center ( Site 0450) | Seoul | 06351 | Korea, Republic of | Details | ||
| Noordwest Ziekenhuisgroep NWZ ( Site 1350) | Alkmaar | 1815 JD | Netherlands | Details | ||
| VU Medisch Centrum ( Site 1352) | Amsterdam | 1081 HV | Netherlands | Details | ||
| UMCG ( Site 1351) | Groningen | 9713 GZ | Netherlands | Details | ||
| UMC St. Radboud ( Site 1356) | Nijmegen | 6525 GA | Netherlands | Details | ||
| Erasmus University Medical Center ( Site 1354) | Rotterdam | 3015 GD | Netherlands | Details | ||
| Capital & Coast District Health Board - Wellington Hospital ( Site 0400) | Wellington | Newtown | 6021 | New Zealand | Details | |
| Dolnoslaskie Centrum Onkologii. ( Site 1001) | Wroclaw | Dolnoslaskie | 53-413 | Poland | Details | |
| Mazowiecki Szpital Onkologiczny ( Site 1015) | Wieliszew | Mazowieckie | 05-135 | Poland | Details | |
| Beskidzkie Centrum Onkologii im. Jana Pawla II ( Site 1005) | Bielsko-Biala | 43-300 | Poland | Details | ||
| Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 1007) | Gdynia | 81-519 | Poland | Details | ||
| Centrum Onkologii. Instytut im. Marii Sklodowskiej-Curie ( Site 1010) | Gliwice | 44-101 | Poland | Details | ||
| Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 1008) | Krakow | 31-826 | Poland | Details | ||
| Zachodniopomorskie Centrum Onkologii ( Site 1013) | Szczecin | 71-730 | Poland | Details | ||
| Centrum Onkologii-Instytut im. Marii Sklodowskiej-Curie ( Site 1000) | Warszawa | 02-781 | Poland | Details | ||
| H.U. Vall de Hebron ( Site 1052) | Barcelona | 08035 | Spain | Details | ||
| Hospital Duran i Reynals ( Site 1053) | Hospitalet de Llobregat | 08907 | Spain | Details | ||
| Hospital Doce de Octubre ( Site 1054) | Madrid | 28024 | Spain | Details | ||
| Hospital Universitario Ramon y Cajal ( Site 1055) | Madrid | 28034 | Spain | Details | ||
| Hospital Clinico San Carlos ( Site 1051) | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario Virgen de la Victoria ( Site 1056) | Malaga | 29010 | Spain | Details | ||
| Hospital Gral Universitario de Valencia ( Site 1050) | Valencia | 46014 | Spain | Details | ||
| Chang Gung Medical Foundation - Kaohsiung ( Site 0501) | Kaohsiung | 83301 | Taiwan | Details | ||
| Taichung Veterans General Hospital ( Site 0506) | Taichung | 407 | Taiwan | Details | ||
| National Cheng Kung University Hospital ( Site 0503) | Tainan | 70403 | Taiwan | Details | ||
| National Taiwan University Hospital ( Site 0500) | Taipei | 10048 | Taiwan | Details | ||
| MacKay Memorial Hospital ( Site 0505) | Taipei | 105 | Taiwan | Details | ||
| Taipei Veterans General Hospital ( Site 0504) | Taipei | 112 | Taiwan | Details | ||
| Linkou Chang Gung Memorial Hospital ( Site 0502) | Taoyuan | 333 | Taiwan | Details | ||
| Basken Adana Dr.Turgut Noyan Uygulama ve Arastirma Merkezi ( Site 1103) | Adana | 01250 | Turkey | Details | ||
| Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1102) | Ankara | 06100 | Turkey | Details | ||
| Ankara Sehir Hastanesi ( Site 1108) | Ankara | 06800 | Turkey | Details | ||
| Istanbul Universitesi Istanbul Tip Fakultesi ( Site 1100) | Istanbul | 34093 | Turkey | Details | ||
| Medipol Universite Hastanesi ( Site 1104) | Istanbul | 34214 | Turkey | Details | ||
| Medical Park Izmir Hastanesi ( Site 1109) | Izmir | 35520 | Turkey | Details | ||
| Kocaeli Universitesi Tip Fakultesi ( Site 1106) | Kocaeli | 41380 | Turkey | Details | ||
| Inonu Universitesi Tip Fakultesi ( Site 1101) | Malatya | 44280 | Turkey | Details | ||
| Norfolk & Norwich University Hospital NHS Foundation Trust ( Site 1206) | Norwich | Norfolk | NR4 7UY | United Kingdom | Details | |
| University Hospital of North Staffordshire ( Site 1202) | Stoke-On-Trent | Staffordshire | ST4 6QG | United Kingdom | Details | |
| Ipswich Hospital ( Site 1207) | Ipswich | Suffolk | IP4 5PD | United Kingdom | Details | |
| St Bartholomew s Hospital ( Site 1205) | London | EC1A 7BE | United Kingdom | Details | ||
| The Royal Marsden Foundation Trust ( Site 1200) | London | SW3 6JJ | United Kingdom | Details | ||
| Imperial Healthcare NHS Trust Charing Cross Hospital ( Site 1204) | London | W6 8RF | United Kingdom | Details | ||
| Lancashire Teaching Hospitals NHS Foundation Trust ( Site 1208) | Preston | PR2 9HT | United Kingdom | Details | ||
| University Hospital Southampton NHS Foundation Trust ( Site 1203) | Southampton | SO16 6YD | United Kingdom | Details | ||
| Royal Marsden NHS Foundation Trust ( Site 1201) | Sutton | SM2 5PT | United Kingdom | Details |