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ID DOID:8557
Name oropharynx cancer
Definition A pharynx cancer that is located_in the oropharynx.
Source DiseaseOntology.org
Alt Ids DOID:9168 DOID:8684 DOID:8851 DOID:8949
Path disease disease of cellular proliferation cancer organ system cancer gastrointestinal system cancer pharynx cancer oropharynx cancer

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT00904345 Phase II Cetuximab Study of Radiation (RT) Concurrent With Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (SCC) Terminated USA 0
NCT01064921 Phase I Cisplatin Vorinostat Ph I Vorinostat in the Treatment of Advanced Staged Oropharyngeal Squamous Cell Carcinoma Completed USA 0
NCT01195922 Phase Ib/II Sirolimus Rapamycin Therapy in Head and Neck Squamous Cell Carcinoma Completed USA 0
NCT01218048 Phase II Cisplatin Carboplatin Cetuximab ERBITUX; Followed by Adjuvant Treatment With Chemoradiation and ERBITUX; for Locally Advanced Head and Neck Squamous Cell Carcinoma Completed USA 0
NCT01467115 Phase II Leucovorin Cisplatin + Docetaxel + Fluorouracil Filgrastim Cetuximab INDUCTION CHEMOTHERAPY FOLLOWED BY CETUXIMAB AND RADIATION THERAPY FOR HEAD AND NECK CANCER Completed USA 0
NCT01663259 Phase I Cetuximab Reduced-intensity Therapy for Oropharyngeal Cancer in Non-smoking HPV-16 Positive Patients Completed USA 0
NCT01732640 Phase Ib/II Afatinib + Carboplatin + Paclitaxel Cisplatin A Phase I/II Study Afatinib/Carboplatin/Paclitaxel Induction Chemotherapy In HPV-Negative HNSCC. Terminated USA 0
NCT01758731 Phase I Cetuximab + Olaparib Study of Olaparib With Radiation Therapy and Cetuximab in Advanced Head and Neck Cancer With Heavy Smoking History Completed USA 0
NCT01783587 Phase I Afatinib Docetaxel Safety Study of Afatinib and Postoperative Radiation Therapy to Treat Head and Neck Cancer Completed USA 0
NCT01810913 Phase II Docetaxel Cisplatin Cetuximab + Docetaxel Radiation Therapy With Cisplatin, Docetaxel, or Cetuximab After Surgery in Treating Patients With Stage III-IV Squamous Cell Head and Neck Cancer Recruiting USA | CAN 1
NCT01824823 Phase II Afatinib Afatinib After Chemoradiation and Surgery in Treating Patients With Stage III-IV Squamous Cell Carcinoma of the Head and Neck at High-Risk of Recurrence Terminated USA 0
NCT01898494 Phase II Cisplatin Carboplatin Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer Active, not recruiting USA 0
NCT01935921 Phase I Cetuximab + Ipilimumab Ipilimumab, Cetuximab, and Intensity-Modulated Radiation Therapy in Treating Patients With Previously Untreated Stage III-IVB Head and Neck Cancer Completed USA 0
NCT02002182 Phase II ADXS11-001 ADXS 11-001 Vaccination Prior to Robotic Surgery, HPV-Positive Oropharyngeal Cancer Completed USA 0
NCT02107235 Phase I Cisplatin Rigosertib Sodium Platinum-based Chemoradiotherapy and Rigosertib in Head and Neck Cancer Completed USA 0
NCT02124850 Phase I Cetuximab A Phase Ib Study of Neoadjuvant Immune Biomarker Modulation With ERBITUX® (Cetuximab) and VTX-2337 Terminated USA 0
NCT02128906 Phase II Cetuximab + Docetaxel Cisplatin Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC Recruiting USA 0
NCT02177838 Phase II Cetuximab + Cisplatin Cetuximab and Radiation Therapy in Treating Patients With Stage III-IV Head and Neck Cancer Terminated USA 0
NCT02196168 Phase II Adavosertib Cisplatin Cisplatin With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer Terminated CAN 0
NCT02201355 Phase I Cisplatin Reduced-Volume Hypofractionated, PET-directed Intensity Modulated Radiotherapy Concurrent With Weekly Cisplatin Chemotherapy for Squamous Cell Carcinoma of the Head and Neck Terminated USA 0
NCT02254278 Phase II Cisplatin Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer Active, not recruiting USA | IRL | CAN 1
NCT02262741 Phase I Tremelimumab Durvalumab A Phase I Study to Evaluate the Safety, Tolerability and Efficacy of MEDI4736 With Tremelimumab or Tremelimumab Alone in Head and Neck Cancer Completed USA | CAN 0
NCT02281955 Phase II Cisplatin Carboplatin Cetuximab De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC Active, not recruiting USA 0
NCT02289209 Phase II Pembrolizumab Reirradiation With MK-3475 in Locoregional Inoperable Recurrence or Second Primary Squamous Cell CA of the Head and Neck Active, not recruiting USA 0
NCT02296684 Phase II Pembrolizumab Cisplatin Immunotherapy With MK-3475 in Surgically Resectable Head and Neck Squamous Cell Carcinoma Active, not recruiting USA 0
NCT02334319 Phase I Ganetespib Ganetespib Window of Opportunity Study in Head and Neck Cancers Terminated USA 0
NCT02358031 Phase III Cetuximab Pembrolizumab Fluorouracil Carboplatin Cisplatin A Study of Pembrolizumab (MK-3475) for First Line Treatment of Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck (MK-3475-048/KEYNOTE-048) Completed 0
NCT02381535 Phase I Cisplatin Onalespib Hsp90 Inhibitor AT13387 in Treating Patients With Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck Receiving Radiation Therapy and Cisplatin Active, not recruiting USA | CAN 0
NCT02426892 Phase II Nivolumab Nivolumab and HPV-16 Vaccination in Patients With HPV-16 Positive Incurable Solid Tumors Completed USA 0
NCT02449681 Phase II TH-4000 Study for Treatment of Patients With Recurrent or Metastatic SCCHN or SCCS Terminated USA | AUS 0
NCT02454179 Phase II Pembrolizumab Acalabrutinib Study of the Combination of ACP-196 and Pembrolizumab in Subjects With Advanced Head and Neck Squamous Cell Carcinoma Completed USA 0
NCT02473731 Phase I CDX-3379 A Window of Opportunity Study of KTN3379 in Surgically Resectable Head and Neck Cancer Patients Completed USA 0
NCT02499120 Phase II Palbociclib Cetuximab Safety And Efficacy Study Of Palbociclib Plus Cetuximab Versus Cetuximab To Treat Head And Neck Cancer Completed USA | SVK | ROU | POL | ITA | HUN | ESP | CZE 7
NCT02499328 Phase Ib/II Danvatirsen + Durvalumab AZD5069 + Durvalumab Durvalumab Danvatirsen Study to Assess Combination of MEDI4736 With Either AZD9150 or AZD5069 in Patients With Metastatic Squamous Cell Carcinoma of Head and Neck Active, not recruiting USA | ITA | GBR | ESP | DEU | BEL 0
NCT02551159 Phase III Cisplatin Durvalumab Carboplatin + Cetuximab + Fluorouracil Tremelimumab Phase III Open Label First Line Therapy Study of MEDI 4736 With or Without Tremelimumab Versus Standard of Care (SOC) in SCCHN Completed USA | SVK | ROU | POL | ITA | GRC | GBR | FRA | ESP | DEU | CAN | BRA | BEL | AUT 9
NCT02555644 Phase I Prexasertib Cisplatin Cetuximab A Study of LY2606368 With Chemotherapy and Radiation in Participants With Head and Neck Cancer Completed USA | FRA 0
NCT02573493 Phase II Cisplatin + Nab-paclitaxel Cetuximab + Nab-paclitaxel Nab-Paclitaxel and Cisplatin or Nab-paclitaxel as Induction Therapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck (HNSCC) Active, not recruiting USA 0
NCT02585973 Phase I Adavosertib + Cisplatin Dose-escalating AZD1775 + Concurrent Radiation + Cisplatin for Intermediate/High Risk HNSCC Completed USA 0
NCT02586207 Phase I Cisplatin + Pembrolizumab Pembrolizumab in Combination With CRT for LA-SCCHN Active, not recruiting USA 0
NCT02643550 Phase Ib/II Cetuximab + Monalizumab Study of IPH2201 (Monalizumab) and Cetuximab in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Completed USA | FRA 0
NCT02734537 Phase II Cisplatin Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery Recruiting USA 0
NCT02741570 Phase III Carboplatin + Cetuximab + Cisplatin + Fluorouracil Ipilimumab + Nivolumab Study of Nivolumab in Combination With Ipilimumab Compared to the Standard of Care (Extreme Study Regimen) as First Line Treatment in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Completed USA | POL | ITA | ISR | IRL | GRC | GBR | FRA | ESP | DEU | CHE | BRA | AUT | AUS 4
NCT02764593 Phase I Nivolumab Cisplatin + Nivolumab Cetuximab + Nivolumab Chemotherapy +/- Nivolumab in Patients With Intermediate and High-Risk Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma Completed USA 0
NCT02769520 Phase II Pembrolizumab Efficacy Study of Pembrolizumab in Relapsed, Locally Recurrent Squamous Cell Cancer of the Head and Neck Active, not recruiting USA 0
NCT02775812 Phase I Cisplatin + Pembrolizumab Cisplatin, Radiation Therapy, and Pembrolizumab in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma Completed USA 0
NCT02777385 Phase II Cisplatin + Pembrolizumab Pembrolizumab in Combination With Cisplatin and Intensity Modulated Radiotherapy (IMRT) in Head and Neck Cancer Completed USA 0
NCT02795156 Phase II Cabozantinib Afatinib Regorafenib Study Assessing Activity of Molecularly Matched Targeted Therapies in Select Tumor Types Based on Genomic Alterations Completed USA 0
NCT02812056 Phase I Alisertib + Sapanisertib Alisertib and TAK-228 in Participants With Human Papilloma Virus (HPV) Associated Malignancies Withdrawn 0
NCT02827838 Phase I Durvalumab Durvalumab Before Surgery in Treating Patients With Oral Cavity or Oropharynx Cancer Completed USA 0
NCT02834013 Phase 0 Ipilimumab + Nivolumab Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Active, not recruiting USA 1
NCT02865135 Phase Ib/II Cyclophosphamide + DPX-E7 Trial To Test Safety And Efficacy Of Vaccination For Incurable HPV 16-Related Oropharyngeal, Cervical And Anal Cancer Completed USA 0
NCT02892201 Phase II Pembrolizumab Pembrolizumab in HNSCC With Residual Disease After Radiation Terminated USA 0
NCT02994069 Phase II Cisplatin Cisplatin + Radiation in SCCHN and Correlation With Oxidative Stress Markers Active, not recruiting USA 0
NCT03001570 Phase II Cetuximab + Radiotherapy Accelerated Modulated Fractionation (SIB-IMRT) for Head and Neck District (FAMOSO) Recruiting ITA 0
NCT03040999 Phase III Cisplatin + Pembrolizumab Cisplatin Study of Pembrolizumab (MK-3475) or Placebo With Chemoradiation in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-412/KEYNOTE-412) Completed USA | TUR | POL | NZL | NLD | ITA | ISR | GBR | FRA | ESP | DEU | CZE | CAN | BRA | BEL | AUT | AUS 4
NCT03107182 Phase II Dexamethasone + Diphenhydramine + Famotidine + Fluorouracil + Hydroxyurea + Paclitaxel Carboplatin + Nab-paclitaxel + Nivolumab Cisplatin Carboplatin + Nivolumab + Paclitaxel Nivolumab Chemotherapy and Locoregional Therapy Trial (Surgery or Radiation) for Patients With Head and Neck Cancer (OPTIMA-II) Completed USA 0
NCT03144778 Phase I Durvalumab Durvalumab + Tremelimumab Checkpoint Inhibitors Assessment in Oropharynx Carcinoma (CIAO) Completed USA 0
NCT03162731 Phase I Ipilimumab + Nivolumab Nivolumab, Ipilimumab, and Radiation Therapy in Treating Patients With Stage IVA-B Head and Neck Cancer Completed USA 0
NCT03179956 Phase I Ribociclib Impact of Ribociclib on Head and Neck Squamous Cell Cancer Terminated USA 0
NCT03238365 Phase I Nivolumab + Tadalafil Nivolumab Nivolumab With or Without Tadalafil in Treating Patients With Recurrent Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery Completed USA 0
NCT03254927 Phase II CDX-3379 + Cetuximab A Study of CDX-3379 and Cetuximab and in Patients With Advanced Head and Neck Squamous Cell Carcinoma Terminated USA 0
NCT03317327 Phase Ib/II Nivolumab REirradiation and Programmed Cell Death Protein 1 (PD-1) Blockade On Recurrent Squamous Cell Head and Neck Tumors (REPORT) Recruiting NOR 0
NCT03341936 Phase II Lirilumab + Nivolumab Adjuvant Nivolumab and Lirilumab in Patients With Relapsed, Resectable Squamous Cell Carcinoma of the Head and Neck Active, not recruiting USA 0
NCT03342352 Phase III Carboplatin + Cetuximab + Cisplatin + Fluorouracil Carboplatin + Cisplatin + Epacadostat + Fluorouracil + Nivolumab Carboplatin + Cisplatin + Fluorouracil + Nivolumab Nivolumab Plus Epacadostat in Combination With Chemotherapy Versus the EXTREME Regimen in Squamous Cell Carcinoma of the Head and Neck (CheckMate 9NA/ECHO-310) Withdrawn 0
NCT03342911 Phase II Carboplatin + Nivolumab + Paclitaxel Nivolumab, Carboplatin, and Paclitaxel in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery Completed USA 0
NCT03349710 Phase III Cetuximab Cisplatin Cetuximab + Nivolumab Cisplatin + Nivolumab Nivolumab or Nivolumab Plus Cisplatin, in Combination With Radiotherapy in Patients With Cisplatin-ineligible or Eligible Locally Advanced Squamous Cell Head and Neck Cancer Completed USA | TUR | POL | ITA | FRA | ESP 4
NCT03356223 Phase II Abemaciclib Evaluation of ABEMACICLIB Monotherapy in Patients With Locally Advanced/Metastatic Head and Neck Cancer After Failure of Platinum and Cetuximab or Anti-EGFR-based Therapy and Harboring an Homozygous Deletion of CDKN2A, and/or an Amplification of CCND1 and/or of CDK6 (ABORL) Completed FRA 0
NCT03370276 Phase Ib/II Cetuximab + Nivolumab Cetuximab & Nivolumab in Patients With Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma Active, not recruiting USA 0
NCT03381183 Phase Ib/II Cyclophosphamide + Durvalumab + Tremelimumab IRX-2 Regimen, Durvalumab, Tremelimumab for Incurable Head and Neck Squamous Cell Carcinoma Active, not recruiting USA 0
NCT03386838 Phase III Linrodostat + Nivolumab Carboplatin + Cetuximab + Cisplatin + Fluorouracil An Immuno-therapy Study of Nivolumab in Combination With Experimental Medication BMS-986205 Compared to Standard of Care EXTREME Regimen in First-line Recurrent/Metastatic Squamous Cell Carcinoma of Head and Neck Withdrawn USA 0
NCT03389477 Phase II Cisplatin + Palbociclib Cetuximab + Palbociclib Los Tres Paso: Neoadjuvant Palbociclib Monotherapy, Concurrent Chemoradiation Therapy, Adjuvant Palbociclib Monotherapy in Patients With p16INK4a Negative, HPV-Unrelated Head and Neck Squamous Cell Carcinoma Active, not recruiting USA 0
NCT03406247 Phase II Ipilimumab + Nivolumab Nivolumab Immunotherapy in Head and Neck Squamous Cell Carcinoma : Phase 2 Trial Evaluating the Efficacy and the Toxicity of Nivolumab Alone, and of the Combination Nivolumab and Ipilimumab (ADJORL1) Recruiting FRA 0
NCT03410615 Phase II Durvalumab + Tremelimumab Cisplatin Durvalumab Cisplatin Plus Radiotherapy vs Durvalumab Plus Radiotherapy Followed by Durvalumab vs Durvalumab Plus Radiotherapy Followed by Tremelimumab and Durvalumab in Intermediate Risk HPV-Positive Oropharyngeal SCC Active, not recruiting ITA | ESP | CAN | BEL 0
NCT03416153 Phase II Cetuximab Individualized Adaptive De-escalated Radiotherapy for HPV-related Oropharynx Cancer Active, not recruiting USA 0
NCT03427411 Phase II Bintrafusp alfa Phase II Trial of M7824 in Subjects With HPV Positive Malignancies Completed USA 0
NCT03480672 Phase II Cisplatin Cisplatin + Pembrolizumab Postoperative aRCH With Cisplatin Versus aRCH With Cisplatin and Pembrolizumab in Locally Advanced Head and Neck Squamous Cell Carcinoma Active, not recruiting DEU 0
NCT03515538 Phase II Cisplatin + RRx-001 RRx-001 Safety and Efficacy of RRx-001 in the Attenuation of Oral Mucositis in Patients Receiving Chemoradiation for the Treatment of Oral Cancers Completed USA 0
NCT03524326 Phase I Cetuximab + Lenvatinib Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma Completed USA 0
NCT03529422 Phase I Durvalumab + Tremelimumab Durvalumab and Tremelimumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN Active, not recruiting USA 0
NCT03575234 Phase Ib/II Cyclophosphamide + IRX-2 + Nivolumab Nivolumab & IRX-2 With Surgery for Resectable Stage III-IVA Oral Cavity Cancer or HPV-Positive Oropharyngeal Cancer Withdrawn USA 0
NCT03576417 Phase III Cisplatin Cisplatin + Nivolumab A Trial Evaluating the Addition of Nivolumab to Cisplatin-RT for Treatment of Cancers of the Head and Neck (NIVOPOSTOP) Active, not recruiting FRA 0
NCT03618953 Phase I Ad-E6E7 + Atezolizumab + MG1-E6E7 This is a Trial of MG1-E6E7 With Ad-E6E7 and Atezolizumab in Patients With HPV Associated Cancers (Kingfisher) Terminated USA | CAN 0
NCT03625323 Phase II Eftilagimod alpha + Pembrolizumab Combination Study With Soluble LAG-3 Fusion Protein Eftilagimod Alpha (IMP321) and Pembrolizumab in Patients With Previously Untreated Unresectable or Metastatic NSCLC, or Recurrent PD-X Refractory NSCLC or With Recurrent or Metastatic HNSCC (TACTI-002) Active, not recruiting USA | GBR | ESP | AUS 1
NCT03635164 Phase I Durvalumab Radiotherapy With Durvalumab Prior to Surgical Resection for HPV Negative Squamous Cell Carcinoma Active, not recruiting USA 0
NCT03669718 Phase II Cemiplimab + ISA101b Cemiplimab A Randomized Phase 2 Study of Cemiplimab +/- ISA101b in HPV16-Positive OPC Active, not recruiting USA | POL | NLD | ITA | HUN | GBR | FRA | ESP | DEU | CZE | BRA | BEL 1
NCT03690986 Phase I Ipilimumab Nivolumab Ipilimumab + Pepinemab Nivolumab + Pepinemab Pepinemab VX15/2503 in Combination With Ipilimumab or Nivolumab in Patients With Head and Neck Cancer Recruiting USA 0
NCT03708224 Phase II Atezolizumab + Emactuzumab Atezolizumab Phase II Study of Perioperative Immunotherapy in Patients With Advanced Non-Virally Associated Squamous Cell Carcinoma Recruiting USA 0
NCT03715946 Phase II Nivolumab Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer Active, not recruiting USA 0
NCT03723967 Phase II Carboplatin + Durvalumab + Paclitaxel FRAIL-IMMUNE (GORTEC 2018-03) - Combination of Durvalumab With Carboplatin/Paclitaxel (FRAIL-IMMUNE) Completed FRA 0
NCT03765918 Phase III Pembrolizumab Cisplatin + Pembrolizumab Cisplatin Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689) Active, not recruiting USA | POL | ISR | IRL | HUN | GBR | FRA | ESP | DEU | CHE | CAN | BRA | BEL | AUT | AUS | ARG 8
NCT03811015 Phase II Cisplatin Nivolumab Cisplatin + Nivolumab Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer Suspended USA 0
NCT03818061 Phase II Atezolizumab + Bevacizumab Atezolizumab and Bevacizumab in Patients With Recurrent or Metastatic Squamous-cell Carcinoma of the Head and Neck (ATHENA) Active, not recruiting FRA 0
NCT03818542 Phase I ABBV-927 ABBV-368 Budigalimab A Study to Assess the Effects of Multiple Study Drug Regimens in Subjects With Newly Diagnosed Locally Advanced Head and Neck Squamous Cell Carcinoma Terminated USA 0
NCT03821935 Phase I ABBV-151 ABBV-151 + Budigalimab Study to Determine the Safety, Tolerability, Pharmacokinetics and RP2D of ABBV-151 as a Single Agent and in Combination With ABBV-181 in Participants With Locally Advanced or Metastatic Solid Tumors Recruiting USA | ISR | FRA | ESP | CAN | BEL | AUS 4
NCT03829722 Phase II Carboplatin + Nivolumab + Paclitaxel Radiotherapy, Carboplatin/Paclitaxel and Nivolumab for High Risk HPV-related Head and Neck Cancer Completed USA 0
NCT03838263 Phase II Nivolumab Feasibility and Tolerance of Nivolumab Neoadjuvant Immunotherapy in High Risk HPV Driven Oropharynx Cancer (IMMUNEBOOST) Active, not recruiting FRA 0
NCT03865082 Phase II IMO-2125 + Ipilimumab + Nivolumab Study of Tilsotolimod in Combination With Nivolumab and Ipilimumab for the Treatment of Solid Tumors (ILLUMINATE-206) Active, not recruiting USA 0
NCT03952585 Phase II Nivolumab Cisplatin De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer Active, not recruiting USA | CAN 0
NCT04001413 Phase II Durvalumab Durvalumab + MEDI0457 Therapy for High-Risk HPV 16-Positive Oropharynx Cancer Patients Withdrawn USA 0
NCT04058145 Phase II Pembrolizumab + Plerixafor AMD3100 Plus Pembrolizumab in Immune Checkpoint Blockade Refractory Head and Neck Squamous Cell Carcinoma Withdrawn USA 0
NCT04080804 Phase II Nivolumab Nivolumab + Relatlimab Ipilimumab + Nivolumab Study of Safety and Tolerability of Nivolumab Treatment Alone or in Combination With Relatlimab or Ipilimumab in Head and Neck Cancer Recruiting USA 0
NCT04096638 Phase I Nivolumab + SB 11285 SB 11285 Evaluating Safety and Efficacy of SB 11285 Alone and in Combination With Nivolumab in Patients With Advanced Solid Tumors Completed USA 0
NCT04116047 Phase III Cisplatin Cisplatin + Durvalumab CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC) (CompARE) Active, not recruiting IRL | GBR 0
NCT04128696 Phase III Pembrolizumab GSK3359609 + Pembrolizumab Study of GSK3359609 and Pembrolizumab in Programmed Death Receptor 1-ligand 1 (PD-L1) Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (INDUCE-3) Terminated USA | ROU | POL | NOR | NLD | ITA | ISR | IRL | GRC | GBR | FRA | ESP | DNK | DEU | CHE | CAN | BRA | AUS | ARG 7
NCT04169074 Phase II Abemaciclib Abemaciclib + Nivolumab Modulation of the Tumor Microenvironment by Abemaciclib in Operable HPV-Negative Head and Neck Cancer (HNC) Recruiting USA 0
NCT04183166 Phase I TG4050 A Clinical Trial Evaluating TG4050 in Head and Neck Cancer Recruiting USA | GBR | FRA | ESP 0
NCT04193293 Phase Ib/II Duvelisib + Pembrolizumab A Study of Duvelisib in Combination With Pembrolizumab in Head and Neck Cancer Terminated USA 0
NCT04196283 Phase I ABBV-368 + IMO-2125 ABBV-368 + IMO-2125 + Nab-paclitaxel ABBV-368 + Budigalimab + IMO-2125 + Nab-paclitaxel A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-368 Plus Tilsotolimod and Other Therapy Combinations in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma Completed USA | NLD | ISR | FRA | ESP | DEU 0
NCT04199104 Phase III Lenvatinib + Pembrolizumab Pembrolizumab A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (LEAP-010) (MK-7902-010) (LEAP-10) Active, not recruiting USA | TUR | POL | ITA | HUN | GBR | FRA | ESP | DEU | CAN | BRA | AUS 7
NCT04278092 Phase II Cetuximab + Paclitaxel Paclitaxel Plus Cetuximab After First-line Checkpoint Inhibitor Failure Recruiting AUT 0
NCT04282109 Phase II Nivolumab + Paclitaxel Cetuximab + Paclitaxel Study to Assess the Efficacy and Safety of Nivolumab in Combination With Paclitaxel in Subjects With Head and Neck Cancer Unable for Cisplatin-based Chemotherapy (NIVOTAX) (NIVOTAX) Completed ESP 0
NCT04287868 Phase Ib/II Bintrafusp alfa + NHS-IL12 + PDS0101 Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies Active, not recruiting USA 0
NCT04290546 Phase I CIML-NK cells + Ipilimumab + Nogapendekin alfa inbakicept CIML-NK cells + Nogapendekin alfa inbakicept CIML NK Cell in Head & Neck Cancer Active, not recruiting USA 0
NCT04398524 Phase II Cemiplimab + ISA101b A Phase II Study of Cemiplimab and ISA101b in Patients With Recurrent/Metastatic HPV16 Positive OPC Active, not recruiting USA | ITA | ISR | GBR | FRA | ESP | DEU | CZE | BEL 0
NCT04428047 Phase II Bintrafusp alfa Evaluation of Bintrafusp Alfa in Operable and Untreated Head and Neck Squamous Cell Carcinoma (ICING) Terminated FRA 0
NCT04428151 Phase II Lenvatinib + Pembrolizumab Docetaxel Paclitaxel Capecitabine Cetuximab Lenvatinib Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009) Active, not recruiting USA | ROU | NOR | ISR | GBR | FRA | ESP | DNK | CAN | BRA | AUS 4
NCT04428333 Phase III Carboplatin + Fluorouracil + Pembrolizumab Cisplatin + Fluorouracil + GSK3359609 + Pembrolizumab Cisplatin + Fluorouracil + Pembrolizumab Carboplatin + Fluorouracil + GSK3359609 + Pembrolizumab Study of GSK3359609 With Pembrolizumab and 5-fluorouracil (5-FU)-Platinum Chemotherapy in Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Terminated USA | SWE | ROU | POL | ITA | IRL | GBR | FRA | ESP | DNK | DEU | CAN | BRA | BEL | AUS | ARG 3
NCT04432597 Phase Ib/II PRGN-2009 Bintrafusp alfa + PRGN-2009 HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers Active, not recruiting USA 0
NCT04445064 Phase II IO102 IO103 Activity and Safety of Peptide-based Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck. (HN1901) Unknown status BEL 0
NCT04453046 Phase I Pembrolizumab Hemopurifier Plus Pembrolizumab in Head and Neck Cancer Terminated USA 0
NCT04459715 Phase III Cisplatin + Xevinapant Cisplatin A Study of Xevinapant (Debio 1143) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX) Terminated USA | POL | ITA | ISR | HUN | GRC | GBR | FRA | ESP | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS | ARG 8
NCT04477759 Phase I Atezolizumab Dose-Escalated Hypofractionated Adaptive Radiotherapy for Head and Neck Cancer (DEHART) Active, not recruiting USA 0
NCT04521621 Phase Ib/II Coxsackievirus A21 + Pembrolizumab A Study of Gebasaxturev (V937) in Combination With Pembrolizumab (MK-3475) in Participants With Advanced/Metastatic Solid Tumors (V937-013) Terminated USA | POL | NOR | ITA | ISR | HUN | FRA | ESP | DEU | CAN 4
NCT04533750 Phase I Peposertib Testing the Addition of M3814 (Peposertib) to Radiation Therapy for Patients With Advanced Head and Neck Cancer Who Cannot Take Cisplatin Recruiting USA 0
NCT04534205 Phase II BNT113 + Pembrolizumab Pembrolizumab A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1 (AHEAD-MERIT) Recruiting USA | TUR | SWE | POL | ITA | HUN | GBR | FRA | ESP | DEU | CZE | CAN | BRA | BEL | AUT | AUS | ARG 5
NCT04574583 Phase Ib/II Bintrafusp alfa + FPV-CV301 + MVA-BN-CV301 + SX-682 Phase I/II Trial Investigating the Safety, Tolerability, Pharmacokinetics, Immune and Clinical Activity of SX-682 in Combination With BinTrafusp Alfa (M7824 or TGF-beta "Trap"/PD-L1) With CV301 TRICOM in Advanced Solid Tumors (STAT) Completed USA 0
NCT04576091 Phase I Elimusertib + Pembrolizumab Testing the Addition of an Anti-cancer Drug, BAY1895344, With Radiation Therapy to the Usual Pembrolizumab Treatment for Recurrent Head and Neck Cancer Active, not recruiting USA 0
NCT04588038 Phase I NT-I7 NT-I7 for the Treatment of Recurrent Squamous Cell Carcinoma of Head and Neck Undergoing Surgery Recruiting USA 0
NCT04590963 Phase III Cetuximab Cetuximab + Monalizumab Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer (INTERLINK-1) Active, not recruiting USA | POL | NLD | ITA | GRC | GBR | FRA | ESP | DEU | CHE | CAN | BRA | BGR | BEL | AUT | AUS | ARG 6
NCT04624113 Phase Ib/II Pembrolizumab + Tazemetostat Tazemetostat and Pembrolizumab in Patients With Pembrolizumab- or Nivolumab-Resistant, Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma Terminated USA 0
NCT04630353 Phase I HB-201 A Study HB-201 in Patients With Newly Diagnosed HPV16+ Oropharynx or Locally Advanced Cervical Cancer Terminated USA 0
NCT04633278 Phase II Pembrolizumab + Vidutolimod CMP-001 in Combination With Pembrolizumab in Subjects With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Terminated USA 0
NCT04634825 Phase II MGA271 + Retifanlimab MGA271 + MGD013 Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer Terminated USA | POL | HUN | ESP | BGR | AUS 1
NCT04643379 Phase II Carboplatin + Olaparib + Pembrolizumab Olaparib + Pembrolizumab Olaparib in Combination With Pembrolizumab and Carboplatin as First-Line Treatment of Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma Active, not recruiting USA 0
NCT04665843 Phase II Atezolizumab + Tiragolumab Atezolizumab A Study of Atezolizumab Plus Tiragolumab and Atezolizumab Plus Placebo as First-Line Treatment in Participants With Recurrent/Metastatic PD-L1 Positive Squamous Cell Carcinoma of the Head and Neck (SKYSCRAPER-09) Active, not recruiting USA | POL | NZL | ITA | HUN | GRC | GBR | FRA | ESP | CZE 3
NCT04671667 Phase II Cisplatin Pembrolizumab Carboplatin Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma Recruiting USA 0
NCT04681469 Phase II Dostarlimab-gxly + Niraparib Induction and Maintenance Treatment With PARP Inhibitor and Immunotherapy in HPV-negative HNSCC (PRIME) Recruiting ITA 0
NCT04704154 Phase II Nivolumab + Regorafenib A Trial to Learn Whether Regorafenib in Combination With Nivolumab Can Improve Tumor Responses and How Safe it is for Participants With Solid Tumors Completed USA | ITA | GBR | FRA | BEL 3
NCT04708470 Phase Ib/II Bintrafusp alfa + Entinostat + NHS-IL12 Entinostat + NHS-IL12 A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers Recruiting USA 0
NCT04722523 Phase I Cemiplimab + Cetuximab + Cisplatin + Docetaxel Carboplatin + Cemiplimab + Cetuximab + Docetaxel A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer Recruiting USA 0
NCT04747054 Phase III Pembrolizumab + Radiotherapy Pembrolizumab Carboplatin + Fluorouracil Cisplatin + Fluorouracil Study on the Efficacy of Treatment by Radiotherapy and Pembrolizumab in Newly Diagnosed Metastatic Head & Neck Cancers (PembroMetaRT) Recruiting FRA 0
NCT04795713 Phase I MT-6402 Study of MT-6402 in Subjects With Advanced Solid Cancer That Expresses PD-L1 Terminated USA 0
NCT04811027 Phase II Eftilagimod alpha + Pembrolizumab Pembrolizumab Combination Study With Eftilagimod Alpha (a Soluble LAG-3 Fusion Protein) and Pembrolizumab in Patients With Recurrent or Metastatic HNSCC (TACTI-003) Active, not recruiting USA | ROU | GBR | ESP | DNK | DEU | BEL | AUS 1
NCT04815720 Phase Ib/II Pembrolizumab + Pepinemab Pepinemab in Combination With Pembrolizumab in Advanced, Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (KEYNOTE B84) Recruiting USA 0
NCT04830592 Phase I NG-641 NG-641 + Pembrolizumab A Study of NG-641 and Pembrolizumab in Squamous Cell Carcinoma of the Head and Neck (MOAT) Active, not recruiting GBR 0
NCT04831320 Phase II Nab-paclitaxel + Nivolumab Nab-Paclitaxel in Combination With Nivolumab to Treat Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma That Progressed on a PD-1 or PD-L1 Inhibitor Active, not recruiting USA 0
NCT04852328 Phase II CUE-101 Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patients With Locally Advanced, HPV16-Positive Oropharyngeal Squamous-Cell Carcinoma Recruiting USA 0
NCT04858269 Phase II Carboplatin + Paclitaxel + Pembrolizumab First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients Recruiting USA 0
NCT04862650 Phase II Carboplatin + Cemiplimab + Paclitaxel Cemiplimab, Low-Dose Paclitaxel and Carboplatin for the Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck Suspended USA 0
NCT04892173 Phase III Cetuximab NBTXR3 NBTXR3 With or Without Cetuximab in LA-HNSCC Recruiting USA | SWE | ROU | ISR | HUN | HRV | GRC | GBR | FRA | FIN | ESP | DEU | CZE | CAN | BRA | BGR | BEL | AUT 9
NCT04892875 Phase I Cisplatin + Zimberelimab Cisplatin Cisplatin + Etrumadenant + Zimberelimab A Study of Concurrent Chemoradiation in Combination With or Without PD1 Inhibitor AB122 Adenosine 2a Receptor / Adenosine 2b Receptor Inhibitor AB928 Therapies in Locally Advanced Head and Neck Cancers (PANTHEoN) Withdrawn 0
NCT04925284 Phase I XB002 Nivolumab + XB002 Study of XB002 in Subjects With Solid Tumors (JEWEL-101) Active, not recruiting USA | NLD | ITA | GBR | FRA | ESP | BEL | AUS 1
NCT04958239 Phase I BI 765179 + Ezabenlimab BI 765179 A Study to Test BI 765179 Alone and in Combination With Ezabenlimab in Patients With Advanced Cancer (Solid Tumors) and BI 765179 in Combination With Pembrolizumab in Patients With Advanced Head and Neck Cancer Recruiting USA | NLD | ITA | ISR | FRA | ESP | DEU | CZE | BRA | BEL | AUS 4
NCT04966481 Phase III Cetuximab + Palbociclib Cetuximab Palbociclib and Cetuximab Versus Cetuximab Monotherapy for Patients With CDKN2A-altered, HPV-unrelated Head and Neck Squamous Cell Carcinoma Who Experienced Disease Progression on a PD-1/L1 Inhibitor Recruiting USA 0
NCT04969861 Phase II NKTR-214 + Pembrolizumab Pembrolizumab BEMPEG With Pembrolizumab vs Pembrolizumab Alone in Patients With Metastatic or Recurrent HNSCC (PROPEL-36) Terminated USA | ITA | GRC | AUT 0
NCT04988074 Phase II Cemiplimab Carboplatin + Cemiplimab + Paclitaxel Trial of Cemiplimab, or Cemip-Chemo Followed by Biomarker-guided Treatment for Pts w/HPV H&N Ca (MINIMA) Recruiting USA 0
NCT04989387 Phase I INCA00186 + Retifanlimab INCA00186 + INCB106385 INCA00186 + INCB106385 + Retifanlimab INCA00186 Study of INCA 0186 in Subjects With Advanced Solid Tumors Active, not recruiting USA | NLD | GBR | ESP | BEL | AUT 0
NCT05053737 Phase Ib/II Atezolizumab Radiotherapy in Combination With Atezolizumab Prior to Surgical Resection for HPV Unrelated HNSCC Suspended USA 0
NCT05057247 Phase II Docetaxel + Duvelisib Duvelisib Plus Docetaxel In Recurrent/Metastatic HNSCC Active, not recruiting USA 0
NCT05108870 Phase Ib/II Carboplatin + HB-201 + Paclitaxel Carboplatin + HB-201 + HB-202 + Paclitaxel TheraT Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers Recruiting USA 0
NCT05136196 Phase II Cabozantinib + Nivolumab BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study Suspended USA 0
NCT05172245 Phase I Cisplatin + Ipatasertib Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer Recruiting USA | CAN 0
NCT05172258 Phase II Ipatasertib + Pembrolizumab Pembrolizumab Testing the Addition of an Anti-cancer Drug, Ipatasertib, to the Usual Immunotherapy Treatment (Pembrolizumab) in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck Recruiting USA 0
NCT05232851 Phase Ib/II PDS0101 + Pembrolizumab PDS0101 A Vaccine (PDS0101) Alone or in Combination With Pembrolizumab for the Treatment of Locally Advanced Human Papillomavirus-Associated Oropharynx Cancer Recruiting USA 0
NCT05271604 Phase II BA3021 A Phase 2 Open Label Study of BA3021 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Recruiting USA 0
NCT05280314 Phase II IO102-IO103 + Pembrolizumab Phase II Trial of Neoadjuvant and Adjuvant IO102-IO103 and Pembrolizumab in Patients With Resectable Tumors Recruiting USA | FRA | ESP | DNK | DEU | AUS 0
NCT05287113 Phase II INCAGN02385 + Retifanlimab Retifanlimab INCAGN02385 + INCAGN02390 + Retifanlimab Study of Retinfanlimab in Combination With INCAGN02385 and INCAGN02390 as First-Line Treatment in Participants With PD-L1-Positive (CPS >= 1) Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck Active, not recruiting USA | POL | NLD | ITA | GRC | FRA | ESP | DEU | CAN | BEL 4
NCT05312710 Phase II APG-157 Safety and Efficacy of APG-157 in Head and Neck Cancer Recruiting USA 0
NCT05317000 Phase I Azacitidine Azacitidine + Nivolumab Nivolumab 5-Azacytidine and/or Nivolumab in Resectable HPV-Associated HNSCC Recruiting USA 0
NCT05329532 Phase Ib/II Modi-1 Modi-1 + Pembrolizumab Modi-1 in Breast, Head and Neck, Ovarian, or Renal Cancer (ModiFY) Recruiting GBR 0
NCT05358548 Phase II Carboplatin + Paclitaxel + Pembrolizumab Carboplatin + Pembrolizumab + Pemetrexed Disodium Carboplatin + Fluorouracil + Pembrolizumab ATATcH Alternating Treatment Plans for Advanced Cancer Recruiting USA 0
NCT05359692 Phase II INCAGN01876 + Retifanlimab INCAGN01876 in Combination With Immunotherapy in Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Withdrawn USA 0
NCT05363709 Phase II Balstilimab A Phase 2 Study To Assess The Effect Of BALSTILIMAB (AGEN2034) On Viral Clearance In HPV-Positive Oropharyngeal Cancer Patients With Persistent HPV Detection In The Oral Rinse And/Or Plasma cfDNA After Definitive Therapy Recruiting USA 0
NCT05366166 Phase II Cisplatin + Olaparib + Pembrolizumab Pembrolizumab Plus Olaparib in LA-HNSCC Recruiting USA 0
NCT05376553 Phase I Cemiplimab + Cisplatin + Docetaxel Study of Cemiplimab - TP Induction Chemotherapy in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck Recruiting USA 0
NCT05386550 Phase III Xevinapant Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION) Terminated USA | ROU | POL | NLD | ITA | ISR | GRC | GBR | FRA | ESP | DEU | CZE | CHE | CAN | BRA | BEL | AUT | ARG 8
NCT05414032 Phase II AZD2936 Molecular Residual Disease Interception in Locoregionally-Advanced High Risk HPV+ and HPV- HNSCC (MERIDIAN) Recruiting CAN 0
NCT05433116 Phase II Lenvatinib + Pembrolizumab Pembrolizumab and Lenvatinib After Definitive Chemoradiation of Locally Advanced HNSCC Recruiting DEU 0
NCT05483400 Phase II Atezolizumab + Tiragolumab Open Label Phase 2 Basket Trial With Atezolizumab and Tiragolumab in Solid Tumors (TIRACAN) Recruiting NLD 0
NCT05535023 Phase II Cemiplimab + THOR-707 Phase 2 Study of Neoadjuvant SAR444245 Plus Cemiplimab in HPV Related Oropharynx Squamous Cell Carcinoma Withdrawn USA 0
NCT05678348 Phase I Pyrimethamine Pyrimethamine as an Inhibitor of NRF2 in HPV-unrelated Locally Advanced Head and Neck Squamous Cell Carcinoma Recruiting USA 0
NCT05712356 Phase II CEND-1 + Cisplatin + Durvalumab + Gemcitabine Cisplatin + Durvalumab + Gemcitabine Paclitaxel Docetaxel CEND-1 + Docetaxel CEND-1 + Paclitaxel A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients With Advanced Solid Tumors (BOLSTER) Recruiting USA | ESP 0
NCT05721755 Phase III Pembrolizumab Carboplatin + Paclitaxel + Pembrolizumab Cisplatin + Fluorouracil + Pembrolizumab Carboplatin + Fluorouracil + Pembrolizumab Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and Neck Recruiting USA 0
NCT05724602 Phase II Xevinapant Radiotherapy Plus Xevinapant in Older Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma (RAVINA) Suspended SVN | NOR | NLD | ITA | IRL | GBR | FRA | ESP | DEU | BEL 0
NCT05784012 Phase Ib/II Dostarlimab-gxly + Niraparib Cisplatin + Dostarlimab-gxly + Niraparib Two-cohort Study of Niraparib and Dostarlimab Plus (Chemo)RadIotherapy in Locally-Advanced Head and Neck Squamous Cell Carcinoma (RADIAN) Recruiting ESP 0
NCT05787639 Phase II Evorpacept Neoadjuvant Immunoradiotherapy With Evorpacept and Pembrolizumab in HPVOPC (Human Papilloma Virus Oropharynx Cancer) Recruiting USA 0
NCT05799144 Phase II pBI-11 vaccine + Pembrolizumab pBI-11 & TA-HPV (With Pembrolizumab as Treatment for Patients w/Advanced, PD-L1 CPS>=1, hrHPV+ Oropharyngeal Cancer Recruiting USA 0
NCT05836324 Phase I INCA33890 A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors Recruiting USA | ITA | GBR | FRA | ESP | DNK | CHE 0
NCT05845307 Phase I C188-9 Randomized Pre-surgical Window-of-Opportunity Trial of TTI-101 in Patients With Stage II-IV Resectable HPV-negative Squamous Cell Carcinoma of the Head and Neck Not yet recruiting USA 0
NCT05980598 Phase II Pembrolizumab + TransCon TLR7/8 Agonist TransCon IL-2 beta/gamma + TransCon TLR7/8 Agonist Pembrolizumab TransCon (TC) TLR7/8 Agonist, TC IL-2 beta/gamma, Pembrolizumab Prior to Surgery for Advanced Head and Neck Squamous Cell Carcinoma (BelieveIT-201) Recruiting USA | POL | ITA | HUN | ESP | DEU 2
NCT05996523 Phase II Pembrolizumab + PRGN-2009 Phase II Trial of Immunotherapeutic HPV Vaccine PRGN-2009 With Pembrolizumab Before Standard Treatment in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal Cancer Recruiting USA 0
NCT06003231 Phase II Disitamab vedotin A Study of Disitamab Vedotin in Previously Treated Solid Tumors That Express HER2 Recruiting USA | ITA | GBR | ESP | CAN | AUS 1
NCT06016920 Phase Ib/II Pembrolizumab + VB10.16 Safety and Efficacy of VB10.16 and Pembrolizumab in Patients With Head-Neck Squamous Cell Carcinoma Recruiting POL | NOR | HUN | GBR | FRA | ESP | DEU | CZE 0
NCT06046482 Phase II Cetuximab + Docetaxel + Hu5F9-G4 Cetuximab + Hu5F9-G4 + Pembrolizumab Phase II Trial of Magrolimab and Cetuximab With Pembrolizumab or Docetaxel for Recurrent/Metastatic Head Neck Squamous Cell Carcinoma Terminated USA 0
NCT06056310 Phase I Cisplatin + Xevinapant Xevinapant Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (HyperlynX) Terminated USA | ISR | ESP | BEL 2
NCT06062420 Phase II Dostarlimab-gxly Dostarlimab-gxly + EOS-448 + GSK6097608 Dostarlimab-gxly + GSK6097608 Dostarlimab-gxly + EOS-448 A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202 Recruiting USA | TUR | ROU | POL | NOR | ITA | HUN | GRC | FRA | FIN | ESP | DNK | DEU | CAN | BRA | ARG 4
NCT06082167 Phase II Pembrolizumab + XL092 Pembrolizumab Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (STELLAR-305) Recruiting USA | SVK | ROU | ITA | FRA | ESP | CZE | BRA | BGR | BEL | AUT | AUS | ARG 4
NCT06096038 Phase Ib/II iC9.CAR-CSPG4 T cells Cyclophosphamide + Fludarabine Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC Recruiting USA 0
NCT06110195 Phase I Carboplatin + Paclitaxel + Xevinapant Study of Xevinapant With Radiation and Chemotherapy for Patients With Head and Neck Cancer Active, not recruiting USA 0
NCT06129864 Phase III MEDI5752 A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy (eVOLVE-HNSCC) Recruiting USA | TUR | POL | ITA | HUN | GBR | FRA | ESP | DEU | CAN | BRA | BEL | AUT 8
NCT06145412 Phase II Cisplatin + Xevinapant A Study of Xevinapant With Cisplatin and Radiation Therapy After Surgery in People With Head and Neck Cancer Active, not recruiting USA 0
NCT06150664 Phase I CTX-8371 A Phase 1 of CTX-8371 in Patients With Advanced Malignancies Recruiting USA 0
NCT06159621 Phase I LVGN3616 LVGN3616 + LVGN7409 CD40 Agonist and PD-1 Inhibitor in HNSCC Recruiting USA 0
NCT06172478 Phase II Patritumab deruxtecan A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors Recruiting USA 2
NCT06223568 Phase II Cisplatin + Docetaxel Cisplatin + Docetaxel + PRGN-2009 Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer Recruiting USA 0
NCT06239220 Phase II Cetuximab + Nogapendekin alfa inbakicept + PD-L1.t-haNK cells PD-L1 t-haNK, N-803 IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC Recruiting USA 0
NCT06254911 Phase II Atezolizumab Pre-operative Atezolizumab in Patients With Resectable, Human Papillomavirus Related Oropharyngeal Carcinoma Recruiting USA 0
NCT06256588 Phase III Dostarlimab-gxly A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma (JADE) Recruiting USA | TUR | SWE | ROU | POL | NOR | ITA | ISR | HUN | GRC | GBR | FRA | ESP | DEU | CZE | CAN | BRA | BEL | AUS | ARG 7
NCT06295731 Phase II INBRX-106 + Pembrolizumab Pembrolizumab INBRX-106 in Combination With Pembrolizumab in First-line PD-L1 CPS>=20 HNSCC (HexAgon-HN) Recruiting USA 0
NCT06319963 Phase Ib/II Lenti-HPV-07 A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer Recruiting USA 0
NCT06366451 Phase I AZD2936 Pembrolizumab AZD7789 MEDI5752 PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, and Sabestomig in HNSCC Recruiting USA 0
NCT06385080 Phase Ib/II Amivantamab-vmjw Amivantamab-vmjw + Pembrolizumab Amivantamab-vmjw + Paclitaxel A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Recurrent/Metastatic Head and Neck Cancer (OrigAMI-4) Recruiting USA | GBR 3
NCT06496178 Phase III Methotrexate Cetuximab Docetaxel MCLA-158 A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients Recruiting USA | ISR | AUS | ARG 3
NCT06525220 Phase III Pembrolizumab MCLA-158 + Pembrolizumab A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer Recruiting USA | ISR | AUS | ARG 3
NCT06557889 Phase II Carboplatin + Fluorouracil + Pembrolizumab Cisplatin + Fluorouracil + Pembrolizumab Reduction in the Number of Chemotherapy Cycles in Combination With Pembrolizumab in First-line Treatment of PD-L1-positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinomas (REDUCE) Recruiting FRA 0
NCT06589609 Phase I FluBHPVE6E7 Phase 1 Clinical Trial of FluBHPVE6E7 Immunotherapy for HPV16-Associated Oropharyngeal Cancer Recruiting AUT 0
NCT06597565 Phase II Gemcitabine + Prexasertib A Phase II Study of ACR-368 and Low Dose Gemcitabine in R/M HNSCC Recruiting USA 0
NCT06636734 Phase II Lovastatin + Pembrolizumab Lovastatin and Pembrolizumab for the Treatment of Patients with Recurrent or Metastatic Head and Neck Cancer, LAPP Trial Not yet recruiting USA 0
NCT06648096 Phase Ib/II Afatinib Afatinib in Patients with Fanconi Anemia (FA) and Advanced Head and Neck Squamous Cell Carcinoma (HNSCC) (AFAN) Not yet recruiting ESP | DEU 0