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| NCT ID | NCT03061812 |
| Title | Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE) (TAHOE) |
| Acronym | TAHOE |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | AbbVie |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | SWE | ROU | POL | NLD | LVA | ITA | HUN | HRV | GRC | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BRA | BGR | BEL | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Clearview Cancer Institute /ID# 155873 | Huntsville | Alabama | 35805 | United States | Details | |
| Mitchell Cancer Institute /ID# 158151 | Mobile | Alabama | 36604 | United States | Details | |
| Carti /Id# 156982 | Little Rock | Arkansas | 72205 | United States | Details | |
| Highlands Oncology Group /ID# 155902 | Springdale | Arkansas | 72762 | United States | Details | |
| Cedars-Sinai Medical Center /ID# 157102 | Beverly Hills | California | 90211 | United States | Details | |
| Moore UC San Diego Cancer Center /ID# 156965 | La Jolla | California | 92093 | United States | Details | |
| Los Angeles Hematology Oncolog /ID# 155879 | Los Angeles | California | 90017 | United States | Details | |
| University of California, Davis Comprehensive Cancer Center /ID# 157001 | Sacramento | California | 95817 | United States | Details | |
| St Jude Hospital dba St Joseph /ID# 155899 | Santa Rosa | California | 95403 | United States | Details | |
| Icri /Id# 157090 | Whittier | California | 90603 | United States | Details | |
| Christiana Care Health Service /ID# 158171 | Newark | Delaware | 19713 | United States | Details | |
| Cancer Specialists of North Florida - Southpoint /ID# 155828 | Jacksonville | Florida | 32256 | United States | Details | |
| Georgia Cancer Center /ID# 160206 | Atlanta | Georgia | 30342 | United States | Details | |
| St. Luke's Mountain States Tumor Institute - Meridian /ID# 164550 | Meridian | Idaho | 83712 | United States | Details | |
| NorthShore University HealthSystem - Evanston Hospital /ID# 157054 | Evanston | Illinois | 60201 | United States | Details | |
| Ingalls Memorial Hosp /ID# 155871 | Harvey | Illinois | 60426 | United States | Details | |
| Goshen Center for Cancer Care /ID# 155946 | Goshen | Indiana | 46526 | United States | Details | |
| University of Louisville /ID# 155947 | Louisville | Kentucky | 40202 | United States | Details | |
| Ochsner Clinic Foundation /ID# 160807 | Baton Rouge | Louisiana | 70836-6455 | United States | Details | |
| Dana-Farber Cancer Institute /ID# 160210 | Boston | Massachusetts | 02215 | United States | Details | |
| Sparrow Regional Cancer Center, Sparrow Health System /ID# 157021 | Lansing | Michigan | 48912 | United States | Details | |
| Nebraska Hematology Oncology /ID# 155900 | Lincoln | Nebraska | 68506 | United States | Details | |
| Gabrail Cancer Center Research /ID# 155920 | Canton | Ohio | 44718 | United States | Details | |
| Oregon Health and Science University /ID# 157055 | Portland | Oregon | 97239 | United States | Details | |
| UPMC Hillman Cancer Ctr /ID# 164403 | Pittsburgh | Pennsylvania | 15232 | United States | Details | |
| Univ Medical Ctr Brackenridge /ID# 156967 | Austin | Texas | 78701 | United States | Details | |
| UT Southwestern Medical Center /ID# 158150 | Dallas | Texas | 75390-7208 | United States | Details | |
| University of Vermont Medical Center /ID# 162317 | Burlington | Vermont | 05401-1473 | United States | Details | |
| University of Washington /ID# 162626 | Seattle | Washington | 98109 | United States | Details | |
| Medical Oncology Associates /ID# 156856 | Spokane | Washington | 99208 | United States | Details | |
| West Virginia Univ School Med /ID# 155872 | Morgantown | West Virginia | 26506 | United States | Details | |
| Blacktown Hospital /ID# 158907 | Blacktown | New South Wales | 2148 | Australia | Details | |
| St George Hospital /ID# 158855 | Kogarah | New South Wales | 2217 | Australia | Details | |
| Southern Medical Day Care Ctr /ID# 158853 | Wollongong | New South Wales | 2500 | Australia | Details | |
| The Prince Charles Hospital /ID# 158897 | Chermside | Queensland | 4032 | Australia | Details | |
| Ballarat Health Service /ID# 158904 | Ballarat | Victoria | 3350 | Australia | Details | |
| Austin Hospital /ID# 158898 | Heidelberg | Victoria | 3084 | Australia | Details | |
| Bobruysk Interdistrict Onco. /ID# 169394 | Bobruisk | 213825 | Belarus | Details | ||
| State Institution Republican Scientific Practical Center of Oncology and Medica /ID# 159325 | Lesnoy | 223040 | Belarus | Details | ||
| Mogilev Reg. Oncologic dispe /ID# 159326 | Mogilev | 212018 | Belarus | Details | ||
| CHU Saint-Pierre /ID# 159521 | Bruxelles | Bruxelles-Capitale | 1000 | Belgium | Details | |
| Grand Hôpital de Charleroi /ID# 158748 | Charleroi | Hainaut | 6000 | Belgium | Details | |
| Cliniques universitaires Saint /ID# 158751 | Brussels | 1200 | Belgium | Details | ||
| Hopital de Jolimont /ID# 159755 | Haine Saint Paul | 7100 | Belgium | Details | ||
| UZ Leuven /ID# 158752 | Leuven | 3000 | Belgium | Details | ||
| CHU de Liege Sart Tilman /ID# 158753 | Liege | 4000 | Belgium | Details | ||
| CHU Charleroi (Vesale) /ID# 159756 | Montigny-le-tilleul | 6110 | Belgium | Details | ||
| Liga Norte Rio Grandense Cont. /ID# 159015 | Natal | Rio Grande Do Norte | 59075-740 | Brazil | Details | |
| Associação Hospital Beneficente São Vicente de Paulo - Hospital São Vicente de P /ID# 159668 | Passo Fundo | Rio Grande Do Sul | 99010-080 | Brazil | Details | |
| Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 159017 | Barretos | Sao Paulo | 14784-400 | Brazil | Details | |
| Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 159666 | Sao Jose Do Rio Preto | Sao Paulo | 15090-000 | Brazil | Details | |
| Instituto Nacional de Câncer José de Alencar Gomes da Silva (INCA) /ID# 159665 | Rio de Janeiro | 20231-050 | Brazil | Details | ||
| UMHAT Tsaritsa Joanna - ISUL /ID# 159641 | Sofia | 1527 | Bulgaria | Details | ||
| UMHAT Sv. Ivan Rilski /ID# 159642 | Sofia | 1612 | Bulgaria | Details | ||
| Cross Cancer Institute /ID# 159519 | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| Juravinski Cancer Clinic /ID# 159514 | Hamilton | Ontario | L8V 1C3 | Canada | Details | |
| Hopital du Sacre Coeur Montreal /ID# 159515 | Montreal | Quebec | H4J 1C5 | Canada | Details | |
| CHU de Quebec-Universite Laval /ID# 159093 | Quebec City | Quebec | G1R 2J6 | Canada | Details | |
| Cisss Du Bas-Saint-Laurent Hopital Regional de Rimouski /Id# 208931 | Rimouski | Quebec | G5L 5T1 | Canada | Details | |
| Jilin Cancer Hosptial /ID# 204059 | Changchun | Jilin | 130000 | China | Details | |
| Klinicki bolnicki centar Sestre milosrdnice /ID# 158811 | Zagreb | Grad Zagreb | 10000 | Croatia | Details | |
| Klinika za plucne bolesti Jordanovac /ID# 159502 | Zagreb | Grad Zagreb | 10000 | Croatia | Details | |
| Klinicki bolnicki centar Rijeka /ID# 159501 | Rijeka | Primorsko-goranska Zupanija | 51000 | Croatia | Details | |
| Thomayerova nemocnice /ID# 159061 | Prague | Praha 4 | 140 59 | Czechia | Details | |
| Nemocnice Na Plesi s.r.o. /ID# 161190 | Nová Ves pod Pleší | Pribram | 262 04 | Czechia | Details | |
| Nemocnice Rudolfa a Stefanie /ID# 159652 | Benesov | 256 01 | Czechia | Details | ||
| Nemocnice Horovice a.s. /ID# 161191 | Horovice | 268 31 | Czechia | Details | ||
| Krajska nemocnice Liberec a.s. /ID# 159653 | Liberec | 602 00 | Czechia | Details | ||
| Herlev Hospital /ID# 158049 | Herlev | Hovedstaden | 2730 | Denmark | Details | |
| Odense Universitets Hospital /ID# 158050 | Odense C | Syddanmark | 5000 | Denmark | Details | |
| Rigshospitalet, Finsen Centre /ID# 158051 | Copenhagen | 2100 | Denmark | Details | ||
| Hopital Haut-Lévêque /ID# 160558 | Pessac CEDEX | Gironde | 33604 | France | Details | |
| Assis.Publique-Hopital Nord /ID# 160554 | Marseille | Provence-Alpes-Cote-d Azur | 13105 | France | Details | |
| Centre Leon Berard /ID# 160561 | Lyon CEDEX 08 | Rhone | 69373 | France | Details | |
| Centre Hosp Intercommunal de Creteil /ID# 162684 | Creteil | Val-de-Marne | 94000 | France | Details | |
| Assistance Publique- Hopitaux /ID# 160552 | Paris | 75020 | France | Details | ||
| Hospital Pontchaillou /ID# 160555 | Rennes | 35033 | France | Details | ||
| KH Martha-Maria Halle Dolau /ID# 158796 | Halle (Saale) | Sachsen-Anhalt | 06120 | Germany | Details | |
| Evangelische Lungenklinik Berl /ID# 159168 | Berlin | 13125 | Germany | Details | ||
| Asklepios Fachkliniken M. Gaut /ID# 158791 | Gauting | 82131 | Germany | Details | ||
| Lungen Clinic Grosshansdorf /ID# 158770 | Grosshansdorf | 22927 | Germany | Details | ||
| Thoraxklinik Heidelberg gGmbH /ID# 159169 | Heidelberg | 69126 | Germany | Details | ||
| Klinikum Kassel /ID# 158788 | Kassel | 34125 | Germany | Details | ||
| Klinik Loewenstein GmbH /ID# 159167 | Löwenstein | 74245 | Germany | Details | ||
| General Hospital of Chest Diseases of Athens SOTIRIA /ID# 159165 | Athens | 11527 | Greece | Details | ||
| Metropolitan Hospital /ID# 159162 | Athens | 18547 | Greece | Details | ||
| University Hospital of Ioannin /ID# 159163 | Ioannina | 45500 | Greece | Details | ||
| Euromedica General Clinic /ID# 159161 | Thessaloniki | 54645 | Greece | Details | ||
| Torokbalinti Tudogyogyintezet /ID# 207053 | Budapest | Pest | 2045 | Hungary | Details | |
| Semmelweis Egyetem /ID# 161197 | Budapest | 1085 | Hungary | Details | ||
| Orszagos Koranyi Pulmonologiai Intezet /ID# 158967 | Budapest | 1122 | Hungary | Details | ||
| Dup_Debreceni Egyetem Klinikai Központ /ID# 161209 | Debrecen | 4032 | Hungary | Details | ||
| Veszprem Megyei Tuedoegyogyint /ID# 162607 | Farkasgyepu | 8582 | Hungary | Details | ||
| Petz Aladar Megyei Oktato Korh /ID# 158978 | Gyor | 9023 | Hungary | Details | ||
| Matrai Gyogyintezet /ID# 158979 | Matrahaza | 3233 | Hungary | Details | ||
| AUSL 8 Arezzo Ospedale San Don /ID# 160967 | Arezzo | 52100 | Italy | Details | ||
| Istituto Europeo di Oncologia /ID# 158942 | Milan | 20141 | Italy | Details | ||
| A.O.U. San Luigi Gonzaga /ID# 158945 | Orbassano | 10043 | Italy | Details | ||
| Ospedale Santa Maria delle Cro /ID# 158940 | Ravenna | 48121 | Italy | Details | ||
| IFO Istituto Nazionale Tumori /ID# 158941 | Rome | 00144 | Italy | Details | ||
| Aichi Cancer Center Hospital /ID# 164975 | Nagoya-shi | Aichi | 464-8681 | Japan | Details | |
| National Cancer Center Hospital East /ID# 165726 | Kashiwa-shi | Chiba | 277-8577 | Japan | Details | |
| Kyushu University Hospital /ID# 165723 | Fukuoka-shi | Fukuoka | 812-8582 | Japan | Details | |
| Kurume University Hospital /ID# 164586 | Kurume-shi | Fukuoka | 830-0011 | Japan | Details | |
| Hokkaido Cancer Center /ID# 165237 | Sapporo-shi | Hokkaido | 003-0804 | Japan | Details | |
| Hyogo Cancer Center /ID# 165125 | Akashi-shi | Hyogo | 673-8558 | Japan | Details | |
| Himeji Medical Center /ID# 165893 | Himeji-shi | Hyogo | 670-0012 | Japan | Details | |
| Duplicate_Kanazawa University Hospital /ID# 165129 | Kanazawa-shi | Ishikawa | 920-8641 | Japan | Details | |
| Yokohama City University Hospital /ID# 165748 | Yokohama-shi | Kanagawa | 236-0004 | Japan | Details | |
| Kanagawa Cardiovascular and Respiratory Center /ID# 164374 | Yokohama-shi | Kanagawa | 236-0051 | Japan | Details | |
| Sendai Kousei Hospital /ID# 166061 | Sendai-shi | Miyagi | 980-0873 | Japan | Details | |
| Japanese Red Cross Okayama Hospital /ID# 165156 | Okayama-shi | Okayama | 700-8607 | Japan | Details | |
| Kansai Medical University Hospital /ID# 165055 | Hirakata-shi | Osaka | 573-1191 | Japan | Details | |
| Kindai University Hospital /ID# 166394 | Osaka-sayama-shi | Osaka | 589-8511 | Japan | Details | |
| Osaka City General Hospital /ID# 165717 | Osaka-shi | Osaka | 534-0021 | Japan | Details | |
| Shizuoka Cancer Center /ID# 166466 | Sunto-gun | Shizuoka | 411-8777 | Japan | Details | |
| Tokushima University Hospital /ID# 165812 | Tokushima-shi | Tokushima | 770-8503 | Japan | Details | |
| National Cancer Center Hospital /ID# 166768 | Chuo-ku | Tokyo | 104-0045 | Japan | Details | |
| The Cancer Institute Hospital Of JFCR /ID# 166249 | Koto-ku | Tokyo | 135-8550 | Japan | Details | |
| Duplicate_Showa University Hospital /ID# 165574 | Shinagawa-ku | Tokyo | 142-0054 | Japan | Details | |
| Wakayama Medical University /ID# 166032 | Wakayama-shi | Wakayama | 641-8510 | Japan | Details | |
| Matsusaka City Hospital /ID# 166126 | Matsusaka-shi MIE | 515-8544 | Japan | Details | ||
| Kanagawa Cancer Center /ID# 165816 | Yokohama | 241-0815 | Japan | Details | ||
| Dong-A University Hospital /ID# 159296 | Busan | Busan Gwang Yeogsi | 49201 | Korea, Republic of | Details | |
| CHA Bundang Medical center CHA University /ID# 204416 | Seongnam si | Gyeonggido | 13496 | Korea, Republic of | Details | |
| Chonnam National University Hospital /ID# 159294 | Gwangju | Jeonranamdo | 61469 | Korea, Republic of | Details | |
| Kyungpook National University Chilgok Hospital /ID# 159292 | Daegu | Seoul Teugbyeolsi | 41404 | Korea, Republic of | Details | |
| Yonsei University Health System, Severance Hospital /ID# 159288 | Seodaemun-gu | Seoul Teugbyeolsi | 03722 | Korea, Republic of | Details | |
| Korea University Guro Hospital /ID# 159293 | Seoul | Seoul Teugbyeolsi | 08308 | Korea, Republic of | Details | |
| Chungbuk National University /ID# 159291 | Cheongju-si | 28644 | Korea, Republic of | Details | ||
| Asan Medical Center /ID# 159290 | Seoul | 05505 | Korea, Republic of | Details | ||
| Pauls Stradins Clinical /ID# 158713 | Riga | LV-1002 | Latvia | Details | ||
| Riga East Clinical University /ID# 158714 | Riga | LV-1079 | Latvia | Details | ||
| Centro de Investigación Clinica Chapultepec /ID# 161000 | Morelia | Michoacan | 58260 | Mexico | Details | |
| Health Pharma Professional Research S.A de C.V /ID# 160020 | Del. Benito Juárez | 03810 | Mexico | Details | ||
| Universitair Medisch Centrum Groningen /ID# 158088 | Groningen | 9713 GZ | Netherlands | Details | ||
| Ziekenhuis St. Jansdal /ID# 158652 | Harderwijk | 3844 DG | Netherlands | Details | ||
| Isala /ID# 158653 | Zwolle | 8025 AB | Netherlands | Details | ||
| Mrukmed. Lekarz Beata Madej Mruk i Partner /ID# 160537 | Rzeszów | Podkarpackie | 35-021 | Poland | Details | |
| Copernicus PL Sp. z o. o., WCO /ID# 160538 | Gdansk | 80-219 | Poland | Details | ||
| Szpitale Pomorskie Sp. z o.o /ID# 160536 | Gdynia | 81-519 | Poland | Details | ||
| Centro Hospitalar Lisboa Norte, EPE /ID# 158687 | Lisbon | Lisboa | 1769-001 | Portugal | Details | |
| IPO Lisboa FG, EPE /ID# 158995 | Lisboa | 1099-023 | Portugal | Details | ||
| Hospital da Luz, SA /ID# 158996 | Lisbon | 1500-650 | Portugal | Details | ||
| Unidade Local Saude Matosinhos /ID# 158682 | Matosinhos | 4464-513 | Portugal | Details | ||
| Hospital CUF Porto /ID# 158685 | Porto | 4100-180 | Portugal | Details | ||
| IPO Porto FG, EPE /ID# 158686 | Porto | 4200-072 | Portugal | Details | ||
| S.C. Centrul de Oncologie Sf. Nectarie S.R.L. /ID# 160847 | Craiova | Dolj | 200347 | Romania | Details | |
| Oncocenter Oncologie Clinica S /ID# 160848 | Timisoara | Timis | 300166 | Romania | Details | |
| Spitalul Judetean de Urgenta A /ID# 160846 | Alba | 510077 | Romania | Details | ||
| National Medical Research Cntr /ID# 207436 | Moscow | Moskovskaya Oblast | 115478 | Russian Federation | Details | |
| LLC Novaya Klinika /ID# 205539 | Pyatigorsk | Stavropol Skiy Kray | 357500 | Russian Federation | Details | |
| Arkhangelsk clinical oncology /ID# 159309 | Arkhangelsk | 163045 | Russian Federation | Details | ||
| Kaluga Regional Clinical Oncol /ID# 160179 | Kaluga | 284007 | Russian Federation | Details | ||
| Clinical Onco Dispensary /ID# 159307 | Omsk | 644013 | Russian Federation | Details | ||
| PMI Euromedservice /ID# 159311 | Pushkin | 196603 | Russian Federation | Details | ||
| Smolensk Regional Onc Clin Dis /ID# 159314 | Smolensk | 214009 | Russian Federation | Details | ||
| LLC BioEq Ltd. /ID# 159310 | St. Petersburg | 197342 | Russian Federation | Details | ||
| N.N. Petrov Research Inst Onc /ID# 159312 | St. Petersburg | 197758 | Russian Federation | Details | ||
| Clinical Center of Nis /ID# 160059 | NIS | Nisavski Okrug | 18000 | Serbia | Details | |
| Institut za onkologiju i radio /ID# 160058 | Belgrade | 11000 | Serbia | Details | ||
| Klinicki centar Srbije /ID# 160024 | Belgrade | 11000 | Serbia | Details | ||
| Institute For Pulmonary Diseas /ID# 158813 | Sremska Kamenica | 21204 | Serbia | Details | ||
| National University Hospital /ID# 158802 | Singapore | 119074 | Singapore | Details | ||
| National Cancer Ctr Singapore /ID# 158803 | Singapore | 169610 | Singapore | Details | ||
| Hospital Clinic /ID# 159031 | Barcelona | 08036 | Spain | Details | ||
| Hospital Santa Creu i Sant Pau /ID# 159028 | Barcelona | 08041 | Spain | Details | ||
| Hospital General Universitario Gregorio Maranon /ID# 159025 | Madrid | 28007 | Spain | Details | ||
| Hospital Universitario HM Sanchinarro /ID# 159024 | Madrid | 28050 | Spain | Details | ||
| Hospital Clinico Universitario de Valencia /ID# 159027 | Valencia | 46010 | Spain | Details | ||
| Sahlgrenska US Gbg /ID# 159534 | Göteborg | Vastra Gotalands Lan | 413 46 | Sweden | Details | |
| Uppsala University Hospital /ID# 159050 | Uppsala | 75185 | Sweden | Details | ||
| National Cheng Kung University Hospital /ID# 158844 | Tainan City | Tainan | 70403 | Taiwan | Details | |
| National Taiwan University Hospital /ID# 158865 | Taipei City | Taipei | 100 | Taiwan | Details | |
| Tri-Service General Hospital /ID# 158985 | Taipei City | Taipei | 11490 | Taiwan | Details | |
| Taichung Veterans General Hosp /ID# 158866 | Taichung City | 40705 | Taiwan | Details | ||
| Hacettepe University Medical Faculty /ID# 159238 | Altindağ | Ankara | 06250 | Turkey | Details | |
| Inonu Universitesi Turgut Ozal /ID# 159241 | Battalgazi/malatya | 44280 | Turkey | Details | ||
| Ege University Medical Faculty /ID# 159239 | Izmir | 35040 | Turkey | Details | ||
| Dr. Suat Seren Gogus Has /ID# 159240 | Izmir | 35110 | Turkey | Details | ||
| Ataturk Gogus Hastaliklari ve /ID# 160056 | Kecioren/ankara | 06280 | Turkey | Details | ||
| CI Zaporizhzhia Regional Clinical Oncological Dispensary /ID# 159122 | Zaporizhzhia | Zaporizka Oblast | 69040 | Ukraine | Details | |
| Municipal institution /ID# 159867 | Chernivtsi | 58013 | Ukraine | Details | ||
| Municipal institution Multifie /ID# 159121 | Dnipro | 49102 | Ukraine | Details | ||
| Regional Center of Oncology /ID# 159123 | Kharkiv | 61070 | Ukraine | Details | ||
| PE PMC Acinus, Medical and Diagnostic Center /ID# 159125 | Kropyvnytskyi | 25006 | Ukraine | Details | ||
| ME Kryviy Rih Oncology Dispensary /ID# 159119 | Kryviy RIH | 50048 | Ukraine | Details | ||
| Volyn Regional Medical Oncology Centre /ID# 159124 | Lutsk | 43018 | Ukraine | Details | ||
| Communal Nonprofit Enterprise "Central City Clinical Hospital" of Uzhhorod City /ID# 159868 | Uzhhorod | 88000 | Ukraine | Details | ||
| Guy's and St Thomas' NHS Found /ID# 159581 | London | London, City Of | SE1 9RT | United Kingdom | Details | |
| United Lincolnshire Hospitals /ID# 159579 | Boston | PE21 9QS | United Kingdom | Details | ||
| Charing Cross Hospital /ID# 159582 | London | W6 8RF | United Kingdom | Details | ||
| Christie NHS Foundation Trust /ID# 159099 | Manchester | M20 4BX | United Kingdom | Details | ||
| James Cook University Hospital /ID# 159583 | Middlesborough | TS4 3BW | United Kingdom | Details | ||
| Royal Preston Hospital /ID# 159578 | Preston | PR2 9HT | United Kingdom | Details |