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Therapy Detail
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| Therapy Name | Rovalpituzumab Tesirine |
| Synonyms | |
| Therapy Description |
Rovalpituzumab Tesirine (Rova-T) is an antibody drug conjugate of pyrrolobenzodiazepine (PBD) cytotoxin D6.5 and human anti-delta-like 3 (DLL3) antibody, which targets and kills DLL-3 expressing tumor cells (PMID: 26311731). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Rovalpituzumab Tesirine | Rova-T|SC16LD6.5 | Rovalpituzumab Tesirine (Rova-T) is an antibody drug conjugate of pyrrolobenzodiazepine (PBD) cytotoxin D6.5 and human anti-delta-like 3 (DLL3) antibody, which targets and kills DLL-3 expressing tumor cells (PMID: 26311731). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02819999 | Phase I | Cisplatin + Etoposide + Rovalpituzumab Tesirine Rovalpituzumab Tesirine | A Study of Rovalpituzumab Tesirine (SC16LD6.5) in the Frontline Treatment of Patients With Delta-Like Protein 3-Expressing Extensive Stage Small Cell Lung Cancer | Terminated | USA | 0 |
| NCT02674568 | Phase II | Rovalpituzumab Tesirine | Study of Rovalpituzumab Tesirine (SC16LD6.5) for Third-line and Later Treatment of Subjects With Relapsed or Refractory Delta-Like Protein 3-Expressing Small Cell Lung Cancer (TRINITY) | Completed | 0 | |
| NCT03061812 | Phase III | Rovalpituzumab Tesirine Topotecan | Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE) (TAHOE) | Completed | USA | TUR | SWE | ROU | POL | NLD | LVA | ITA | HUN | HRV | GRC | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BRA | BGR | BEL | AUS | 11 |
| NCT02709889 | Phase Ib/II | Rovalpituzumab Tesirine | Rovalpituzumab Tesirine in Delta-Like Protein 3-Expressing Advanced Solid Tumors | Terminated | USA | 0 |
| NCT03543358 | Phase II | Rovalpituzumab Tesirine | A Long-Term Study of Rovalpituzumab Tesirine | Completed | USA | 0 |
| NCT02874664 | Phase I | Rovalpituzumab Tesirine | A Study of Rovalpituzumab Tesirine to Study Cardiac Ventricular Repolarization in Subjects With Small Cell Lung Cancer | Completed | USA | CAN | 0 |
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