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| NCT ID | NCT03498521 |
| Title | A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site (CUPISCO) |
| Acronym | CUPISCO |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | No |
| Sponsors | Hoffmann-La Roche |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | TUR | ROU | POL | NOR | NLD | LVA | ITA | ISR | IRL | HUN | HRV | GRC | GBR | FRA | FIN | EST | ESP | DNK | DEU | CZE | CHE | BRA | BGR | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Blacktown Hospital | Blacktown | New South Wales | NSW 2148 | Australia | Details | |
| GenesisCare North Shore | St Leonards | New South Wales | 2065 | Australia | Details | |
| Icon Cancer Foundation | South Brisbane | Queensland | 4101 | Australia | Details | |
| Flinders Medical Centre | Bedford Park | South Australia | 5042 | Australia | Details | |
| Peter MacCallum Cancer Center | Melbourne | Victoria | 3000 | Australia | Details | |
| Lkh-Univ. Klinikum Graz | Graz | 8036 | Austria | Details | ||
| Lkh Salzburg - Univ. Klinikum Salzburg | Salzburg | 5020 | Austria | Details | ||
| Medizinische Universität Wien | Wien | 1090 | Austria | Details | ||
| Hospital Sao Rafael - HSR | Salvador | Bahia | 41253-190 | Brazil | Details | |
| Hospital de Cancer de Barretos | Barretos | São Paulo | 14784-400 | Brazil | Details | |
| Instituto do Cancer do Estado de Sao Paulo - ICESP | Sao Paulo | São Paulo | 01246-000 | Brazil | Details | |
| Instituto Nacional de Cancer - INCa | Rio de Janeiro | 20560-120 | Brazil | Details | ||
| MHAT Nadezhda | Sofia | 1330 | Bulgaria | Details | ||
| MBAL Serdika EOOD | Sofia | 1632 | Bulgaria | Details | ||
| Bradford Hill Centro de Investigaciones Clinicas | Recoleta | 8420383 | Chile | Details | ||
| James Lind Centro de Investigación Del Cáncer | Temuco | 4800827 | Chile | Details | ||
| Clinica del Country | Bogota | 11001 | Colombia | Details | ||
| Inst. Nacional de Cancerologia | Bogota | Colombia | Details | |||
| Oncomedica S.A. | Monteria | 230002 | Colombia | Details | ||
| Clinical Hospital Centre Zagreb | Zagreb | 10000 | Croatia | Details | ||
| Masarykuv onkologicky ustav | Brno | 656 53 | Czechia | Details | ||
| Fakultni nemocnice Olomouc | Olomouc | 779 00 | Czechia | Details | ||
| Fakultni Poliklinika Vseobecne Fakultni Niemocnice | Praha 2 | 128 08 | Czechia | Details | ||
| Aarhus Universitetshospital | Aarhus N | 8200 | Denmark | Details | ||
| Rigshospitalet | København Ø | 2100 | Denmark | Details | ||
| North Estonia Medical Centre, Oncology and hematology Clinic | Tallinn | 13419 | Estonia | Details | ||
| Helsinki University Central Hospital | Helsinki | 00250 | Finland | Details | ||
| Tampere University Hospital | Tampere | 33520 | Finland | Details | ||
| Ico - Paul Papin | Angers | 49000 | France | Details | ||
| CHRU Besançon | Besançon | 25030 | France | Details | ||
| Institut Bergonie | Bordeaux | 33076 | France | Details | ||
| CRLCC-Francois Baclesse | Caen | 14076 | France | Details | ||
| Centre Jean Perrin Centre Regional de Lutte Contre Le Cancer D auvergne | Clermont-ferrand | 63003 | France | Details | ||
| Centre Leon Berard | Lyon | 69008 | France | Details | ||
| Institut Paoli-Calmettes | Marseille Cedex 09 | 13273 | France | Details | ||
| Institut régional du Cancer Montpellier | Montpellier | 34298 | France | Details | ||
| Centre Antoine Lacassagne | Nice | 06189 | France | Details | ||
| Institut Curie | Paris | 75231 | France | Details | ||
| CHU Lyon - Centre Hospitalier Lyon Sud | Pierre-Benite (Lyon) | 69495 | France | Details | ||
| Centre Eugene Marquis | Rennes | 35042 | France | Details | ||
| CHU Strasbourg Hôpital Hautepierre | Strasbourg | 67098 | France | Details | ||
| Hopital Foch | Suresnes | 92151 | France | Details | ||
| Institut Gustave Roussy | Villejuif | 94805 | France | Details | ||
| Universitätsklinikum Augsburg | Augsburg | 86156 | Germany | Details | ||
| Charité-Universitätsm. Berlin | Berlin | 13353 | Germany | Details | ||
| Onkologisches Zentrum - Onkologie Dachau | Dachau | 85221 | Germany | Details | ||
| Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden | Dresden | 01307 | Germany | Details | ||
| Kliniken Essen-Mitte, Evang. Huyssens-Stiftung, Klinik für Internistische Onkologie / Haematologie | Essen | 45136 | Germany | Details | ||
| Universitätsklinikum Frankfurt, UCT | Frankfurt | 60590 | Germany | Details | ||
| Universitätsklinikum Heidelberg | Heidelberg | 69120 | Germany | Details | ||
| SLK-Kliniken Heilbronn GmbH;Klinik für Innere Medizin III | Heilbronn | 74078 | Germany | Details | ||
| Universitätsklinikum Jena, Klinik für Innere Medizin II | Jena | 07740 | Germany | Details | ||
| Klinikum Mannheim III. Medizinische Klinik | Mannheim | 68167 | Germany | Details | ||
| Klinikum der LMU München, Campus Großhadern, Krebszentrum München | München | 81377 | Germany | Details | ||
| Universitätsklinikum Münster, Medizinische Klinik A, Translationale Onkologie | Münster | 48149 | Germany | Details | ||
| RED-Oncology GmbH | Oldenburg / Holstein | 23758 | Germany | Details | ||
| Anticancer Hospital Ag Savas | Athens | 115 22 | Greece | Details | ||
| IASO General Hospital of Athens | Athens | 155 62 | Greece | Details | ||
| Univ General Hosp Heraklion | Heraklion | 711 10 | Greece | Details | ||
| Uni Hospital of Ioannina | Ioannina | 455 00 | Greece | Details | ||
| Theagenio Anticancer Hospital | Thessaloniki | 540 07 | Greece | Details | ||
| Orszagos Onkologiai Intezet | Budapest | 1122 | Hungary | Details | ||
| Budapesti Uzsoki Utcai Kórház | Budapest | 1145 | Hungary | Details | ||
| Bács-Kiskun Vármegyei Oktatókórház | Kecskemét | 6000 | Hungary | Details | ||
| St Vincent'S Uni Hospital | Dublin | D04 T6F4 | Ireland | Details | ||
| Waterford Regional Hospital | Waterford | X91 ER8E | Ireland | Details | ||
| Rabin MC | Petach Tikva | 4941492 | Israel | Details | ||
| Chaim Sheba medical center, Oncology division | Ramat Gan | 5262000 | Israel | Details | ||
| Tel Aviv Sourasky Medical Ctr | Tel Aviv | 6423906 | Israel | Details | ||
| U. O. Oncologia Medica, Ospedale Santa Chiara | Pisa | Basilicata | 56100 | Italy | Details | |
| Policlinico Univ. - A.O. Mater Domini | Catanzaro | Calabria | 88100 | Italy | Details | |
| Istituto Nazionale Tumori Fondazione G. Pascale | Napoli | Campania | 80131 | Italy | Details | |
| Arcispedale Santa Maria Nuova | Reggio Emilia | Emilia-Romagna | 42100 | Italy | Details | |
| Asst Papa Giovanni XXIII | Bergamo | Lombardia | 24128 | Italy | Details | |
| Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda) | Milano | Lombardia | 20162 | Italy | Details | |
| IRCCS Istituto Oncologico Veneto (IOV) | Padova | Veneto | 35128 | Italy | Details | |
| National Cancer Center Hospital East | Chiba | 277-8577 | Japan | Details | ||
| National Hospital Organization Kyushu Cancer Center | Fukuoka | 811-1395 | Japan | Details | ||
| Seoul National University Hospital | Seoul | 03080 | Korea, Republic of | Details | ||
| Asan Medical Center | Seoul | 05505 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| Severance Hospital, Yonsei University Health System | Seoul | 120-752 | Korea, Republic of | Details | ||
| Riga East Clinical University Hospital Latvian Oncology Centre | Riga | LV-1079 | Latvia | Details | ||
| Health Pharma Professional Research | CD Mexico | Mexico CITY (federal District) | 03810 | Mexico | Details | |
| AVIX Investigación Clínica S.C | Monterrey | Nuevo LEON | 64710 | Mexico | Details | |
| Erasmus MC | Rotterdam | 3015 GD | Netherlands | Details | ||
| Universitair Medisch Centrum Utrecht | Utrecht | 3584 CX | Netherlands | Details | ||
| Ziekenhuis VieCuri Medisch Centrum | Venlo | 5912 BL | Netherlands | Details | ||
| Sørlandet Sykehus Kristiansand | Kristiansand | 4604 | Norway | Details | ||
| Akershus universitetssykehus HF | Lørenskog | 1478 | Norway | Details | ||
| Oslo universitetssykehus HF, Ullevål, Kreftsenteret | Oslo | 0450 | Norway | Details | ||
| Instituto Nacional de Enfermedades Neoplasicas | Lima | 15038 | Peru | Details | ||
| Oncosalud Sac | Lima | 41 | Peru | Details | ||
| Szpital Uniwersytecki w Krakowie, Oddzia? Kliniczny Kliniki Onkologii | Kraków | 30-688 | Poland | Details | ||
| IPO do Porto | Porto | 4200-072 | Portugal | Details | ||
| Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj Napoca | Cluj Napoca | 400015 | Romania | Details | ||
| Centrul de Oncologie Sfantul Nectarie | Craiova | 200347 | Romania | Details | ||
| Institutul Regional de Oncologie Iasi | Iasi | 700483 | Romania | Details | ||
| Oncocenter Timisoara | Timi?oara | 300166 | Romania | Details | ||
| Hospital Sant Joan Despi- Moises Broggi | Sant Joan Despí | Barcelona | 08970 | Spain | Details | |
| Complejo Hospitalario de Navarra | Pamplona | Navarra | 31008 | Spain | Details | |
| Complexo Hospitalario de Vigo. Hospital Álvaro Cunqueiro | Vigo | Pontevedra | 36312 | Spain | Details | |
| Hospital Clínic i Provincial | Barcelona | 08036 | Spain | Details | ||
| Institut Catala d Oncologia Hospital Duran i Reynals | Barcelona | 08908 | Spain | Details | ||
| Hospital Ramon y Cajal | Madrid | 28034 | Spain | Details | ||
| Hospital Universitario 12 de Octubre | Madrid | 28041 | Spain | Details | ||
| Hospital Clinico Universitario Virgen de la Victoria | Malaga | 29010 | Spain | Details | ||
| Hospital Universitario Virgen Macarena | Sevilla | 41009 | Spain | Details | ||
| Hospital Universitari i Politecnic La Fe | Valencia | 46026 | Spain | Details | ||
| Hospital Universitario Miguel Servet | Zaragoza | 50009 | Spain | Details | ||
| Universitaetsspital Basel | Basel | 4031 | Switzerland | Details | ||
| UniversitätsSpital Zürich | Zürich | 8091 | Switzerland | Details | ||
| Ramathibodi Hospital;Medicine/Oncology | Bangkok | 10400 | Thailand | Details | ||
| Faculty of Med. Siriraj Hosp. | Bangkok | 10700 | Thailand | Details | ||
| Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital | Adana | 01250 | Turkey | Details | ||
| Ankara University Medical Faculty | Ankara | 06100 | Turkey | Details | ||
| Ankara Oncology Hospital | Ankara | 06200 | Turkey | Details | ||
| Akdeniz University Medical Faculty | Antalya | 07070 | Turkey | Details | ||
| Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi | Edirne | 22030 | Turkey | Details | ||
| Istanbul University Cerrahpa?a-Cerrahpa?a Medical Faculty | Istanbul | 34098 | Turkey | Details | ||
| ?zmir Medical Point | Kar?iyaka | 35575 | Turkey | Details | ||
| Hacettepe Uni Medical Faculty Hospital | S?hhiye, Ankara | 06100 | Turkey | Details | ||
| Royal United Hospital | Bath | BA1 3NG | United Kingdom | Details | ||
| Velindre Cancer Centre | Cardiff | CF14 2TL | United Kingdom | Details | ||
| Western General Hospital | Edinburgh | EH4 2XU | United Kingdom | Details | ||
| Hammersmith Hospital | London | W12 0HS | United Kingdom | Details | ||
| Christie Hospital NHS Trust | Manchester | M20 4BX | United Kingdom | Details | ||
| Freeman Hospital | Newcastle upon Tyne | NE7 7DN | United Kingdom | Details | ||
| Southampton General Hospital | Southampton | SO16 6YD | United Kingdom | Details | ||
| Torbay Hospital | Torquay | TQ27AA | United Kingdom | Details |