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| NCT ID | NCT03924856 |
| Title | Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866) (KEYNOTE-866) |
| Acronym | KEYNOTE-866 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | SWE | POL | ITA | ISR | IRL | HUN | GBR | FRA | ESP | DNK | DEU | CAN | BEL | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Scripps MD Anderson ( Site 0010) | La Jolla | California | 92037 | United States | Details | |
| Providence Saint John's Health Center ( Site 0075) | Santa Monica | California | 90404 | United States | Details | |
| Georgetown University Medical Center ( Site 0022) | Washington | District of Columbia | 20007 | United States | Details | |
| AdventHealth Orlando-AdventHealth Medical Group Hematology & Oncology at Orlando ( Site 0005) | Orlando | Florida | 32804 | United States | Details | |
| Parkview Cancer Institute ( Site 0077) | Fort Wayne | Indiana | 46845 | United States | Details | |
| Indiana University Melvin and Bren Simon Cancer Center ( Site 0004) | Indianapolis | Indiana | 46202 | United States | Details | |
| Ochsner Medical Center ( Site 0049) | New Orleans | Louisiana | 70121 | United States | Details | |
| New England Cancer Specialists ( Site 0070) | Scarborough | Maine | 04074 | United States | Details | |
| UMass Memorial Medical Center ( Site 0051) | Worcester | Massachusetts | 01655 | United States | Details | |
| Henry Ford Hospital ( Site 0039) | Detroit | Michigan | 48202 | United States | Details | |
| Mercy Hospital Saint Louis ( Site 0064) | Saint Louis | Missouri | 63141 | United States | Details | |
| Morristown Medical Center ( Site 0015) | Morristown | New Jersey | 07960 | United States | Details | |
| UNM Comprehensive Cancer Center-Clinical Research Office ( Site 0045) | Albuquerque | New Mexico | 87106 | United States | Details | |
| New York University Perlmutter Cancer Center ( Site 0008) | New York | New York | 10016 | United States | Details | |
| University Hospitals Cleveland Medical Center ( Site 0038) | Cleveland | Ohio | 44106 | United States | Details | |
| Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0021) | Tulsa | Oklahoma | 74146 | United States | Details | |
| Portland VA Medical Center ( Site 0084) | Portland | Oregon | 97239 | United States | Details | |
| Allegheny General Hospital ( Site 0048) | Pittsburgh | Pennsylvania | 15212 | United States | Details | |
| MD Anderson Cancer Center ( Site 0063) | Houston | Texas | 77030 | United States | Details | |
| Central Texas Veterans Healthcare System ( Site 0057) | Temple | Texas | 76504 | United States | Details | |
| Inova Schar Cancer Institute ( Site 0007) | Fairfax | Virginia | 22031 | United States | Details | |
| Northwest Medical Specialties, PLLC ( Site 0061) | Puyallup | Washington | 98373 | United States | Details | |
| Seattle Cancer Care Alliance/Univ of Washington Medical Center ( Site 0033) | Seattle | Washington | 98109 | United States | Details | |
| Charleston Area Medical Center ( Site 0023) | Charles Town | West Virginia | 25304 | United States | Details | |
| Mid North Coast Cancer Institute ( Site 1256) | Port Macquarie | New South Wales | 2444 | Australia | Details | |
| Southside Cancer Care Centre ( Site 1252) | Sydney | New South Wales | 2228 | Australia | Details | |
| Cairns Base Hospital ( Site 1257) | Cairns | Queensland | 4870 | Australia | Details | |
| Eastern Health ( Site 1255) | Box Hill | Victoria | 3128 | Australia | Details | |
| Peninsula Health Frankston Hospital ( Site 1258) | Frankston | Victoria | 3199 | Australia | Details | |
| UZ Brussel ( Site 0358) | Brussels | Bruxelles-Capitale, Region De | 1090 | Belgium | Details | |
| Jessa Ziekenhuis ( Site 0360) | Hasselt | Limburg | 3500 | Belgium | Details | |
| CHU UCL Namur Site de Godinne ( Site 0354) | Yvoir | Namur | 5530 | Belgium | Details | |
| O.L.V. Ziekenhuis Aalst ( Site 0356) | Aalst | Oost-Vlaanderen | 9300 | Belgium | Details | |
| AZ Maria Middelares Gent ( Site 0353) | Gent | Oost-Vlaanderen | 9000 | Belgium | Details | |
| Tom Baker Cancer Centre ( Site 0100) | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| Nova Scotia Health Authority ( Site 0109) | Halifax | Nova Scotia | B3H 1V7 | Canada | Details | |
| Kingston Health Sciences Centre ( Site 0103) | Kingston | Ontario | K7L 2V7 | Canada | Details | |
| Lakeridge Health ( Site 0104) | Oshawa | Ontario | L1G 2B9 | Canada | Details | |
| Sunnybrook Research Institute ( Site 0110) | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Princess Margaret Cancer Centre ( Site 0107) | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0105) | Montreal | Quebec | H1T 2M4 | Canada | Details | |
| Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0 | Quebec City | Quebec | G1J 1Z4 | Canada | Details | |
| Herlev og Gentofte Hospital. ( Site 0402) | Herlev | Hovedstaden | 2730 | Denmark | Details | |
| Rigshospitalet University Hospital ( Site 0401) | Kobenhavn | Hovedstaden | 2100 | Denmark | Details | |
| Odense Universitetshospital ( Site 0403) | Odense | Syddanmark | 5000 | Denmark | Details | |
| CHU de Bordeaux- Hopital Saint Andre ( Site 0456) | Bordeaux | Aquitaine | 33075 | France | Details | |
| Centre Leon Berard ( Site 0465) | Lyon | Auvergne | 69373 | France | Details | |
| Centre Francois Baclesse ( Site 0459) | Caen | Calvados | 14075 | France | Details | |
| Centre Armoricain de Radiotherapie Imagerie medicale et Oncologie ( Site 0457) | Plerin | Cotes-d Armor | 22190 | France | Details | |
| Hopital Foch ( Site 0483) | Suresnes | Hauts-de-Seine | 92150 | France | Details | |
| CHU de Montpellier - Hopital Saint-Eloi ( Site 0469) | Montpellier | Languedoc-Roussillon | 34295 | France | Details | |
| Institut de Cancerologie de l Ouest Site Paul Papin ( Site 0453) | Angers | Maine-et-Loire | 49000 | France | Details | |
| Hopital Robert Schuman ( Site 0452) | Metz | Moselle | 57070 | France | Details | |
| Centre Jean Perrin ( Site 0460) | Clermont-Ferrand | Puy-de-Dome | 63011 | France | Details | |
| Clinique Victor Hugo ( Site 0463) | Le Mans | Sarthe | 72000 | France | Details | |
| CHU de Rouen ( Site 0493) | Rouen | Seine-Maritime | 76031 | France | Details | |
| Institut Sainte Catherine ( Site 0454) | Avignon | Vaucluse | 84918 | France | Details | |
| Klinikum der Eberhard-Karls-Universitaet Tuebingen ( Site 0502) | Tuebingen | Baden-Wurttemberg | 72076 | Germany | Details | |
| Universitaetsklinikum Erlangen ( Site 0505) | Erlangen | Bayern | 91058 | Germany | Details | |
| Universitaetsklinikum Magdeburg A.o.R. ( Site 0516) | Magdeburg | Sachsen-Anhalt | 39120 | Germany | Details | |
| Universitaetsklinikum Carl Gustav Carus ( Site 0519) | Dresden | Sachsen | 01307 | Germany | Details | |
| Universitaetsklinikum Schleswig-Holstein-Campus Lubeck ( Site 0512) | Luebeck | Schleswig-Holstein | 23538 | Germany | Details | |
| Charite Universitaetsmedizin Berlin ( Site 0515) | Berlin | 10117 | Germany | Details | ||
| Vivantes Klinikum am Urban ( Site 0522) | Berlin | 10967 | Germany | Details | ||
| Pecsi Tudomanyegyetem AOK ( Site 1009) | Pecs | Baranya | 7624 | Hungary | Details | |
| SZTE Szent-Gyorgyi Albert Klinikai Kozpont ( Site 1010) | Szeged | Csongrad | 6720 | Hungary | Details | |
| Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 1002) | Szolnok | Jasz-Nagykun-Szolnok | 5004 | Hungary | Details | |
| Bajcsy Zsilinszki Korhaz es Rendelointezet ( Site 1001) | Budapest | 1106 | Hungary | Details | ||
| Debreceni Egyetem Klinikai Kozpont ( Site 1006) | Debrecen | 4032 | Hungary | Details | ||
| Petz Aladar Megyei Oktato Korhaz ( Site 1012) | Gyor | 9023 | Hungary | Details | ||
| Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 1007) | Kaposvar | 7400 | Hungary | Details | ||
| Cork University Hospital ( Site 0722) | Cork | T12 DC4A | Ireland | Details | ||
| Tallaght University Hospital ( Site 0710) | Dublin | D24 DH74 | Ireland | Details | ||
| University Hospital Waterford ( Site 0723) | Waterford | X91ER8E | Ireland | Details | ||
| Ha Emek Medical Center ( Site 0808) | Afula | 1834111 | Israel | Details | ||
| Soroka Medical Center ( Site 0806) | Beer Sheva | 8410101 | Israel | Details | ||
| Rambam Health Care Campus-Oncology Division ( Site 0802) | Haifa | 3109601 | Israel | Details | ||
| Shaare Zedek Medical Center ( Site 0809) | Jerusalem | 9103102 | Israel | Details | ||
| Hadassah Ein Kerem Medical Center ( Site 0810) | Jerusalem | 9112001 | Israel | Details | ||
| Meir Medical Center ( Site 0803) | Kfar Saba | 4428164 | Israel | Details | ||
| Rabin Medical Center ( Site 0804) | Petach Tikva | 4941492 | Israel | Details | ||
| Sheba Medical Center ( Site 0801) | Ramat Gan | 5265601 | Israel | Details | ||
| Sourasky Medical Center ( Site 0807) | Tel Aviv | 6423906 | Israel | Details | ||
| Yitzhak Shamir Medical Center ( Site 0805) | Zerifin | 7030001 | Israel | Details | ||
| Policlinico Gemelli di Roma ( Site 0558) | Roma | Abruzzo | 00168 | Italy | Details | |
| Policlinico di Modena ( Site 0553) | Modena | Emilia-Romagna | 41124 | Italy | Details | |
| A.O.U. Policlinico Vittorio Emanuele - Presidio Gaspare Rodolico ( Site 0559) | Catania | 95123 | Italy | Details | ||
| Istituto Nazionale Studio e Cura dei Tumori ( Site 0551) | Milano | 20133 | Italy | Details | ||
| Istituto Nazionale Per Lo Studio E La Cura Dei Tumori ( Site 0552) | Napoli | 80131 | Italy | Details | ||
| Fondazione Salvatore Maugeri IRCCS. ( Site 0554) | Pavia | 27100 | Italy | Details | ||
| Azienda Ospedaliera San Camillo Forlanini ( Site 0560) | Roma | 00152 | Italy | Details | ||
| Azienda Ospedaliera Santa Maria Terni ( Site 0557) | Terni | 05100 | Italy | Details | ||
| Hirosaki University Hospital ( Site 1502) | Hirosaki | Aomori | 036-8563 | Japan | Details | |
| National Cancer Center Hospital East ( Site 1504) | Kashiwa | Chiba | 2778577 | Japan | Details | |
| Ehime University Hospital ( Site 1508) | Toon | Ehime | 791-0295 | Japan | Details | |
| Sapporo Medical University Hospital ( Site 1501) | Sapporo | Hokkaido | 060-8543 | Japan | Details | |
| University of Tsukuba Hospital ( Site 1503) | Tsukuba | Ibaraki | 305-8576 | Japan | Details | |
| Yokosuka Kyosai Hospital ( Site 1509) | Yokosuka | Kanagawa | 238-8558 | Japan | Details | |
| Nara Medical University Hospital ( Site 1510) | Kashihara | Nara | 634-8522 | Japan | Details | |
| Saitama Medical University International Medical Center ( Site 1505) | Hidaka | Saitama | 350-1298 | Japan | Details | |
| Chiba Cancer Center ( Site 1506) | Chiba | 260-8717 | Japan | Details | ||
| Harasanshin Hospital ( Site 1515) | Fukuoka | 812-0033 | Japan | Details | ||
| Hiroshima City Hiroshima Citizens Hospital ( Site 1513) | Hiroshima | 730-8518 | Japan | Details | ||
| Nagano Municipal Hospital ( Site 1516) | Nagano | 381-8551 | Japan | Details | ||
| Osaka Metropolitan University Hospital ( Site 1512) | Osaka | 545-8586 | Japan | Details | ||
| Tokushima University Hospital ( Site 1514) | Tokushima | 770-8503 | Japan | Details | ||
| Tokyo Medical and Dental University Hospital ( Site 1517) | Tokyo | Japan | Details | |||
| National Cancer Center ( Site 1354) | Goyang-si | Kyonggi-do | 10408 | Korea, Republic of | Details | |
| Seoul National University Bundang Hospital ( Site 1356) | Seongnam-si | Kyonggi-do | 13620 | Korea, Republic of | Details | |
| Korea University Anam Hospital ( Site 1351) | Seoul | 02841 | Korea, Republic of | Details | ||
| Seoul National University Hospital ( Site 1352) | Seoul | 03080 | Korea, Republic of | Details | ||
| Asan Medical Center ( Site 1355) | Seoul | 05505 | Korea, Republic of | Details | ||
| Samsung Medical Center ( Site 1353) | Seoul | 06351 | Korea, Republic of | Details | ||
| Centro de Urologia Avanzada del Noreste S.A. de C.V. ( Site 0254) | Monterrey | Nuevo Leon | 66269 | Mexico | Details | |
| Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V. ( Site 0300) | Aguascalientes | 20010 | Mexico | Details | ||
| Centro Estatal de Cancerologia de Chihuahua ( Site 0253) | Chihuahua | 31000 | Mexico | Details | ||
| Instituto Nacional de Cancerologia ( Site 0256) | Tlalpan | 14080 | Mexico | Details | ||
| Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego ( Site 1062) | Wroclaw | Dolnoslaskie | 50-556 | Poland | Details | |
| Centrum Onkologii im.prof. F. Lukaszczyka w Bydgoszczy ( Site 1068) | Bydgoszcz | Kujawsko-pomorskie | 85-796 | Poland | Details | |
| Europejskie Centrum Zdrowia Otwock ( Site 1057) | Otwock | Mazowieckie | 05-400 | Poland | Details | |
| Luxmed Onkologia sp. z o. o. ( Site 1051) | Warszawa | Mazowieckie | 01-748 | Poland | Details | |
| Beskidzkie Centrum Onkologii im. Jana Pawla II ( Site 1060) | Bielsko-Biala | Slaskie | 43-300 | Poland | Details | |
| Clinic of Bashkortostan State Medical University ( Site 0869) | Ufa | Baskortostan, Respublika | 450081 | Russian Federation | Details | |
| Ivanovo Regional Oncology Dispensary ( Site 0852) | Ivanovo | Ivanovskaya Oblast | 153040 | Russian Federation | Details | |
| Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0861) | Krasnoyarsk | Krasnoyarskiy Kray | 660133 | Russian Federation | Details | |
| Kursk Regional Clinical Oncology Dispensary ( Site 0854) | Kursk | Kurskaya Oblast | 305524 | Russian Federation | Details | |
| FSBI ""United Hospital with Polyclinic"" of the Administrative Department of the President of the Ru | Moscow | Moskva | 119285 | Russian Federation | Details | |
| Central Clinical Hospital with outpatient Clinic ( Site 0856) | Moscow | Moskva | 121359 | Russian Federation | Details | |
| Bayandin Murmansk Regional Clinical Hospital ( Site 0859) | Murmansk | Murmanskaya Oblast | 183057 | Russian Federation | Details | |
| Volga District Medical Center Federal Medical and Biological Agency ( Site 0857) | Nizhny Novgorod | Nizhegorodskaya Oblast | 603074 | Russian Federation | Details | |
| Omsk Clinical Oncology Dispensary ( Site 0865) | Omsk | Omskaya Oblast | 644013 | Russian Federation | Details | |
| Leningrad Regional Oncology Center ( Site 0868) | Saint Petersburg | Sankt-Peterburg | 188663 | Russian Federation | Details | |
| Clinical Hospital Saint Luka ( Site 0867) | St. Petersburg | Sankt-Peterburg | 194044 | Russian Federation | Details | |
| Saratov State Medical University n.a. V.I.Razumovskiy ( Site 0866) | Saratov | Saratovskaya Oblast | 410012 | Russian Federation | Details | |
| Hospital San Pedro de Alcantara ( Site 0654) | Caceres | Extremadura | 10003 | Spain | Details | |
| H. de Gerona Dr. Josep Trueta ( Site 0651) | Girona | Gerona | 17007 | Spain | Details | |
| Hospital Universitario Ramon y Cajal ( Site 0660) | Madrid | Madrid, Comunidad De | 28034 | Spain | Details | |
| Hospital Universitario Quiron Madrid ( Site 0657) | Pozuelo de Alarcon | Madrid, Comunidad De | 28223 | Spain | Details | |
| Instituto Valenciano de Oncologia - IVO ( Site 0662) | Valencia | Valenciana, Comunitat | 46009 | Spain | Details | |
| Hospital del Mar ( Site 0653) | Barcelona | 08003 | Spain | Details | ||
| Hospital Universitario San Carlos ( Site 0663) | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario La Paz ( Site 0661) | Madrid | 28046 | Spain | Details | ||
| Hospital Nuestra Sra. de Valme ( Site 0658) | Sevilla | 41014 | Spain | Details | ||
| Laenssjukhuset Ryhov ( Site 1205) | Jonkoping | Jonkopings Lan | 551 85 | Sweden | Details | |
| Akademiska Sjukhuset ( Site 1201) | Uppsala | Uppsala Lan | 751 85 | Sweden | Details | |
| Cancercentrum ( Site 1204) | Umea | Vasterbottens Lan | 901 85 | Sweden | Details | |
| Ramathibodi Hospital. ( Site 1451) | Bangkok | Krung Thep Maha Nakhon | 10400 | Thailand | Details | |
| Faculty of Medicine Siriraj Hospital ( Site 1452) | Bangkok | Krung Thep Maha Nakhon | 10700 | Thailand | Details | |
| Maharaj Nakorn Chiangmai Hospital ( Site 1453) | Chiang Mai | 50200 | Thailand | Details | ||
| Srinagarind Hospital ( Site 1454) | Khon Kaen | 40002 | Thailand | Details | ||
| Hacettepe Universitesi Tıp Fakultesi ( Site 0911) | Ankara | 06100 | Turkey | Details | ||
| Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0910) | Istanbul | 34096 | Turkey | Details | ||
| TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 0906) | Istanbul | 34722 | Turkey | Details | ||
| Universitesi Pendik Egitim ve Arastirma Hastanesi ( Site 0901) | Istanbul | 34899 | Turkey | Details | ||
| Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi ( Site 0909) | Konya | 42080 | Turkey | Details | ||
| Sakarya Universitesi Tip Fakultesi ( Site 0913) | Sakarya | 54290 | Turkey | Details | ||
| Karadeniz Teknik Universitesi Tip Fakultesi Farabi Hastanesi ( Site 0904) | Trabzon | 61080 | Turkey | Details | ||
| Cherkasy Regional Oncology Dispensary ( Site 0959) | Cherkasy | Cherkaska Oblast | 18009 | Ukraine | Details | |
| MI Dnipr Regional Clinical Hospital named after I.I. Mechnikov ( Site 0963) | Dnipropetrovsk | Dnipropetrovska Oblast | 49005 | Ukraine | Details | |
| Regional Oncological Hospital ( Site 0956) | Dnipro | Dnipropetrovska Oblast | 49055 | Ukraine | Details | |
| Dnipropetrovsk City Multidiscipline Clinical Hosp. 4 of DRC ( Site 0951) | Dnipro | Dnipropetrovska Oblast | 49102 | Ukraine | Details | |
| Reg. Clinical Center of Urology and Nephrology n.a. V. I. Shapoval ( Site 0969) | Kharkiv | Kharkivska Oblast | 61037 | Ukraine | Details | |
| CNPE "Regional Center of Oncology" ( Site 0958) | Kharkiv | Kharkivska Oblast | 61070 | Ukraine | Details | |
| National Cancer Institute of the MoH of Ukraine ( Site 0962) | Kyiv | Kyivska Oblast | 03022 | Ukraine | Details | |
| Lviv Regional Clinical Hospital ( Site 0955) | Lviv | Lvivska Oblast | 79000 | Ukraine | Details | |
| Lviv State Oncology Regional Treatment and Diagnostic Center ( Site 0967) | Lviv | Lvivska Oblast | 79000 | Ukraine | Details | |
| Kyiv City Clinical Oncology Center ( Site 0960) | Kyiv | 03115 | Ukraine | Details | ||
| Aberdeen Royal Infirmary ( Site 0708) | Aberdeen | Aberdeen City | AB25 2ZN | United Kingdom | Details | |
| Torbay Hospital ( Site 0704) | Torquay | Devon | TQ2 7AA | United Kingdom | Details | |
| Kent and Canterbury Hospital ( Site 0709) | Canterbury | England | CT1 3NG | United Kingdom | Details | |
| Lister Hospital ( Site 0715) | Stevenage | Hertfordshire | SG1 4AB | United Kingdom | Details | |
| The Royal Marsden Foundation Trust ( Site 0702) | London | London, City Of | SW3 6JJ | United Kingdom | Details | |
| Imperial College Healthcare NHS Trust ( Site 0721) | London | London, City Of | W6 8RF | United Kingdom | Details | |
| Norfolk & Norwich University Hospital NHS Foundation Trust ( Site 0725) | Norwich | Norfolk | NR4 7UY | United Kingdom | Details | |
| Royal Cornwall Hospital ( Site 0703) | Truro | TR1 3LJ | United Kingdom | Details |