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ID DOID:6477
Name invasive bladder transitional cell carcinoma
Definition
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer urinary system cancer urinary bladder cancer bladder carcinoma bladder urothelial carcinoma invasive bladder transitional cell carcinoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
PIK3CA mutant Cisplatin + Gemcitabine + Sorafenib invasive bladder transitional cell carcinoma predicted - resistant detail...
BRAF G469A Trametinib invasive bladder transitional cell carcinoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01326871 Phase Ib/II ALT-801 A Study of ALT-801 in Combination With Cisplatin and Gemcitabine in Muscle Invasive or Metastatic Urothelial Cancer Completed USA 0
NCT02546661 Phase I Danvatirsen + Durvalumab Durvalumab + Selumetinib Fexagratinib Durvalumab + Olaparib Durvalumab Durvalumab + Fexagratinib Durvalumab + Vistusertib Adavosertib + Durvalumab Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer (BISCAY) Active, not recruiting USA | GBR | FRA | ESP | CAN 0
NCT02560636 Phase I Pembrolizumab Pembrolizumab in Muscle Invasive/Metastatic Bladder Cancer (PLUMMB) Unknown status GBR 0
NCT02660034 Phase I Pamiparib + Tislelizumab The Safety, Pharmacokinetics and Antitumor Activity of BGB-A317 in Combination With BGB-290 in Participants With Advanced Solid Tumors Completed USA | NZL | GBR | FRA | ESP | AUS 0
NCT03244384 Phase III Pembrolizumab Pembrolizumab in Treating Patients With Locally Advanced Bladder Cancer Active, not recruiting USA 1
NCT03534804 Phase II Cabozantinib + Pembrolizumab Cabozantinib Plus Pembrolizumab as First-Line Therapy for Cisplatin-Ineligible Advanced Urothelial Carcinoma (PemCab) Active, not recruiting USA 0
NCT03549715 Phase Ib/II Cisplatin + Doxorubicin + Durvalumab + Methotrexate + Tremelimumab + Vinblastine Cisplatin + Doxorubicin + Durvalumab + Methotrexate + Vinblastine NEoadjuvant Dose-dense MVAC In cOmbination With Durvalumab and Tremelimumab in Muscle-invasive Urothelial Carcinoma (NEMIO) Active, not recruiting FRA 0
NCT03558087 Phase II Cisplatin + Gemcitabine + Nivolumab Gemcitabine, Cisplatin, Plus Nivolumab in Patients With Muscle-invasive Bladder Cancer With Selective Bladder Sparing Completed USA 0
NCT03697850 Phase II Atezolizumab Atezolizumab After Chemo-radiotherapy for MIBC Patients Not Eligible for Radical Cystectomy (BladderSpar) Active, not recruiting FRA 0
NCT03747419 Phase II Avelumab Avelumab and Radiation in Muscle-Invasive Bladder Cancer Recruiting USA 0
NCT03837821 Phase I Abemaciclib Window of Opportunity Trial of Abemaciclib for Bladder Cancer Recruiting USA 0
NCT03844256 Phase Ib/II Nivolumab Ipilimumab + Nivolumab A Study of Mitomycin-c/ Capecitabine ChemoRadiotherapy Combined With Nivolumab Monotherapy or Ipilumimab and Nivolumab, as Bladder Sparing Curative Treatment for Muscle Invasive Bladder Cancer: the CRIMI Study (CRIMI) Recruiting NLD 0
NCT03924856 Phase III Cisplatin + Gemcitabine + Pembrolizumab Cisplatin + Gemcitabine Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866) (KEYNOTE-866) Active, not recruiting USA | TUR | SWE | POL | ITA | ISR | IRL | HUN | GBR | FRA | ESP | DNK | DEU | CAN | BEL | AUS 6
NCT03924895 Phase III Pembrolizumab Perioperative Pembrolizumab (MK-3475) Plus Cystectomy Versus Cystectomy Alone in Cisplatin-ineligible Participants With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905) Active, not recruiting USA | TUR | SWE | POL | ITA | ISR | IRL | HUN | GBR | FRA | ESP | DNK | DEU | CAN | BEL | AUS | ARG 11
NCT04138628 Phase II Atezolizumab Treatment Of Metastatic Bladder Cancer at the Time Of Biochemical reLApse Following Radical Cystectomy (TOMBOLA) Recruiting DNK 0
NCT04186013 Phase II Atezolizumab Efficacy of Atezolizumab Concurrent With Radiotherapy in Patients With Muscle-invasive Bladder cancer Active, not recruiting ESP 0
NCT04197986 Phase III Infigratinib Study of Oral Infigratinib for the Adjuvant Treatment of Subjects With Invasive Urothelial Carcinoma With Susceptible FGFR3 Genetic Alterations Terminated USA | NLD | ITA | GRC | GBR | FRA | ESP | DEU | CAN | BGR | BEL 0
NCT04586244 Phase II Retifanlimab Epacadostat + Retifanlimab Epacadostat An Umbrella Study to Determine the Safety and Efficacy of Various Monotherapy or Combination Therapies in Neoadjuvant Urothelial Carcinoma (Optimus) Terminated USA | ITA | FRA 0
NCT04658862 Phase III Cisplatin Cetrelimab + TAR-200 Gemcitabine A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder Active, not recruiting USA | TUR | POL | ITA | HUN | GRC | FRA | ESP | DEU | CZE | CAN | BRA | BEL | AUT | AUS | ARG 9
NCT04700124 Phase III Enfortumab vedotin-ejfv + Pembrolizumab Cisplatin + Gemcitabine Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304) (KEYNOTE-B15) Active, not recruiting USA | ROU | POL | ITA | ISR | HUN | HRV | GRC | GBR | FRA | ESP | DEU | CZE | CAN | BGR | AUS | ARG 12
NCT04871529 Phase II Avelumab + Carboplatin + Gemcitabine Testing the Addition of an Anti-Cancer Immunotherapy Drug, Avelumab, to Gemcitabine and Carboplatin Chemotherapy Prior to Surgery in Muscle Invasive Urinary Tract Cancer vs. Surgery Alone in Patients Who Are Not Able to Receive Cisplatin Therapy (SWOG GAP TRIAL) Suspended USA 0
NCT04960709 Phase III Durvalumab + Enfortumab vedotin-ejfv + Tremelimumab Treatment Combination of Durvalumab, Tremelimumab and Enfortumab Vedotin or Durvalumab and Enfortumab Vedotin in Patients With Muscle Invasive Bladder Cancer Ineligible to Cisplatin (VOLGA) Recruiting USA | TUR | POL | NLD | ITA | ISR | GRC | GBR | FRA | ESP | DEU | CAN | BRA | AUT | ARG 13
NCT05239624 Phase II Enfortumab vedotin-ejfv + Pembrolizumab Enfortumab Vedotin and Pembrolizumab in People With Bladder Cancer Recruiting USA 0
NCT05241340 Phase II PF-06801591 Neoadjuvant Sasanlimab With Radiation as an in Situ Vaccine for Cisplatin-ineligible Muscle Invasive Bladder Cancer (RAD-VACCINE) Recruiting USA 0
NCT05496192 Phase II Nivolumab BMS-986298 A Study of Nivolumab Intravenous (IV) to Subcutaneous (SC) Switch in Adjuvant Melanoma and Bladder Cancer Withdrawn ESP | DEU 0
NCT05756569 Phase II Enfortumab vedotin-ejfv + Pembrolizumab Enfortumab Vedotin Plus Pembrolizumab for the Treatment of Locally Advanced or Metastatic Bladder Cancer of Variant Histology Recruiting USA 0
NCT05833867 Phase I Sacituzumab govitecan-hziy Adaptive RADiation Therapy With Concurrent Sacituzumab Govitecan (SG) for Muscle Invasive Bladder Cancer Recruiting USA 0
NCT05839119 Phase I Cisplatin + Degarelix + Gemcitabine Targeting Androgen Signaling in Urothelial Cell Carcinoma - Neoadjuvant (TASUC-Neo) Recruiting USA 0
NCT06133517 Phase II AB154 + Sacituzumab govitecan-hziy + Zimberelimab PeRioperative Immunotherapy Combined With Sacituzumab Govitecan in Muscle Invasive blAdder Cancer Not yet recruiting ESP 0
NCT06470282 Phase Ib/II Enfortumab vedotin-ejfv + Pembrolizumab Enfortumab Vedotin and Pembrolizumab Combined With Radiotherapy in Muscle Invasive Bladder Cancer Not yet recruiting USA 0
NCT06511648 Phase II Cetrelimab + Erdafitinib Erdafitinib Erdafitinib Monotherapy or in Combination With Cetrelimab in Muscle-invasive Bladder Cancer Patients With Fibroblast Growth Factor Receptor (FGFR ) Gene Alterations (SOGUG-NEOWIN) Recruiting ITA | GBR | FRA | ESP 0
NCT06529822 Phase I Nivolumab + Personalized cancer vaccine + Poly ICLC Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease Not yet recruiting USA 0
NCT06534983 Phase II Nivolumab Autogene cevumeran + Nivolumab A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran With Nivolumab Versus Nivolumab Alone in Participants With High-Risk Muscle-Invasive Urothelial Carcinoma (MIUC) (IMCODE004) Recruiting USA | ITA | DEU | CAN | AUS 0
NCT06571708 Phase II Cemiplimab + Cisplatin + Gemcitabine Cemiplimab + Cisplatin + Fianlimab + Gemcitabine A Study of Gemcitabine/Cisplatin Plus Cemiplimab (REGN2810, Anti-PD-1) With or Without Fianlimab (REGN3767, Anti-LAG-3) in Patients With Localized Muscle-invasive Bladder Cancer (NeoSTOP-IT) (NeoSTOP-IT) Not yet recruiting USA 0
NCT06623162 Phase II PF-06801591 Cisplatin + Gemcitabine Sasanlimab As Maintenance Treatment Based on Clinical Response to Neoadjuvant Treatment in Molecularly Categorized Muscle Invasive Bladder Cancer Patients (SASAN-SPARING) Not yet recruiting ESP 0