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| NCT ID | NCT04194944 |
| Title | A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer (LIBRETTO-431) |
| Acronym | LIBRETTO-431 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Eli Lilly and Company |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | TUR | ROU | POL | NLD | ITA | ISR | GRC | GBR | FRA | ESP | DEU | CZE | CAN | BRA | BEL | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Centro de Oncología e Investigación de Buenos Aires | Berazategui | Buenos Aires | B1884BBF | Argentina | Details | |
| Fundacion CENIT para la Investigacion en Neurociencias | Caba | Buenos Aires | 1125 | Argentina | Details | |
| Clinica Viedma | Viedma | Río Negro | R8500ACE | Argentina | Details | |
| Alexander Fleming | Ciudad de Buenos Aires | C1426ANZ | Argentina | Details | ||
| Clínica El Castaño | San Juan | 5400 | Argentina | Details | ||
| Chris O'Brien Lifehouse | Camperdown | New South Wales | 2050 | Australia | Details | |
| Calvary Mater Newcastle | Waratah | New South Wales | 2298 | Australia | Details | |
| Westmead Hospital | Westmead | New South Wales | 2145 | Australia | Details | |
| Monash Health | Clayton | Victoria | 3168 | Australia | Details | |
| Peter MacCallum Cancer Centre | Melbourne | Victoria | 3000 | Australia | Details | |
| St Vincent's Hospital | Melbourne | Victoria | 3065 | Australia | Details | |
| Peninsula Oncology Centre | Frankston | 3199 | Australia | Details | ||
| UZ Brussel | Brussels | Bruxelles-Capitale, Région De | 1090 | Belgium | Details | |
| AZ Nikolaas | Sint Niklaas | Oost-Vlaanderen | B-9100 | Belgium | Details | |
| UZ Leuven | Leuven | Vlaams-Brabant | 3000 | Belgium | Details | |
| AZ Delta | Roeselare | West Flanders | 8800 | Belgium | Details | |
| UZ Gent Hospital | Gent | 9000 | Belgium | Details | ||
| AZ Sint-Maarten, Campus Leopoldstraat 2 | Mechelen | 2800 | Belgium | Details | ||
| CHU UCL Namur/Site Sainte Elisabeth | Namur | 5000 | Belgium | Details | ||
| Núcleo de Oncologia da Bahia | Salvador | Bahia | 40170-070 | Brazil | Details | |
| Hospital de Cancer de Londrina | Londrina | Paraná | 86015-520 | Brazil | Details | |
| Hospital São Lucas da PUCRS | Porto Alegre | Rio Grande Do Sul | 90610-000 | Brazil | Details | |
| Grupo COI - Clínicas Oncológicas Integradas | Rio de Janeiro | RJ | 22775-001 | Brazil | Details | |
| Fundação Pio XII - Hospital de Câncer de Barretos | Barretos | Sao Paulo | 14784-400 | Brazil | Details | |
| Instituto D'Or de Pesquisa e Ensino (IDOR) | Sao Paulo | SP | 04543-000 | Brazil | Details | |
| Instituto Nacional de Câncer - INCA | Rio de Janeiro | 20231-050 | Brazil | Details | ||
| Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA | Rio de Janeiro | 22250-905 | Brazil | Details | ||
| Hospital Sírio Libanês | Sao Paolo | 01308-060 | Brazil | Details | ||
| Icesp - Instituto Do Câncer Do Estado de São Paulo | Sao Paulo | 01246000 | Brazil | Details | ||
| Hospital Sírio Libanês | São Paulo | 01308-060 | Brazil | Details | ||
| Cross Cancer Institute | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| Princess Margaret Cancer Centre | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| Beijing Cancer hospital | Beijing | Beijing | 100142 | China | Details | |
| First affiliated Hospital of Sun Yat-Sen University | Guangzhou | Guangdong | 510080 | China | Details | |
| The First Affiated Hospital Of Guangzhou Medical Collage | Guangzhou | Guangzhou | 510120 | China | Details | |
| Harbin Medical University Cancer Hospital | Harbin | Heilongjiang | 150081 | China | Details | |
| Wuhan Union Hospital | Wuhan | Hubei | 430022 | China | Details | |
| Hunan Provincial People's Hospital | Changsha | Hunan | 410005 | China | Details | |
| Hunan Cancer Hospital | Changsha | Hunan | 410013 | China | Details | |
| Changzhou No.2 People's Hospital | Changzhou | Jiangsu | China | Details | ||
| Jilin Cancer Hospital | Changchun | Jilin | China | Details | ||
| Shanghai Pulmonary Hospital | Shanghai | Shanghai | 200433 | China | Details | |
| West China Hospital of Sichuan University | Cheng Du | Sichuan | 610041 | China | Details | |
| Xinjiang Medical University Cancer Hospital - Urumqi | Urumqi | Xinjiang | 830000 | China | Details | |
| Zhejiang Cancer Hospital | Hangzhou | Zhejiang | China | Details | ||
| First Affiliated Hosp of College of Med, Zhejiang University | Hangzhou | 310003 | China | Details | ||
| Shanghai Chest Hospital | Shanghai | 200030 | China | Details | ||
| Fakultni nemocnice Olomouc | Olomouc | 779 00 | Czechia | Details | ||
| Nemocnice AGEL Ostrava - Vitkovice a.s. | Ostrava - Vitkovice | 70384 | Czechia | Details | ||
| Fakultni nemocnice Bulovka | Praha 8 | 180 81 | Czechia | Details | ||
| Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone | Marseille | Bouches-du-Rhône | 13385 | France | Details | |
| Institut Régional du Cancer Montpellier | Montpellier Cedex 5 | Hérault | 34298 | France | Details | |
| Chu Grenoble Alpes | La Tronche | Isère | 38700 | France | Details | |
| Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne | Clermont-Ferrand | Puy-de-Dôme | 63011 | France | Details | |
| Centre Leon Berard | Lyon | Rhône-Alpes | 69373 | France | Details | |
| Hopitaux Universitaires Paris Centre-Hopital Cochin | Paris | 75014 | France | Details | ||
| Thoraxklinik-Heidelberg gGmbH | Heidelberg | Baden-Württemberg | 69126 | Germany | Details | |
| Asklepios Fachkliniken München-Gauting | Gauting | Bayern | 82131 | Germany | Details | |
| Klinikverbund Kempten-Oberallgäu | Immenstadt | Bayern | 87509 | Germany | Details | |
| Franziskus-Hospital Harderberg | Georgsmarienhütte | Niedersachsen | 49124 | Germany | Details | |
| Universitätsmedizin Göttingen | Göttingen | Niedersachsen | 37075 | Germany | Details | |
| University Hospital of Cologne | Köln | Nordrhein-Westfalen | 50937 | Germany | Details | |
| LungenClinic Grosshansdorf | Grosshansdorf | Schleswig-Holstein | 22927 | Germany | Details | |
| Charite Universitätsmedizin Berlin Campus Benjamin Franklin | Berlin | 12203 | Germany | Details | ||
| Sotiria Thoracic Diseases Hospital of Athens | Athens | Attikí | 115 27 | Greece | Details | |
| University General Hospital of Heraklion | Heraklion | Krítí | 711 10 | Greece | Details | |
| European Interbalkan Medical Center | Thessaloniki | Thessaloníki | 570 01 | Greece | Details | |
| G. Papanikolaou General Hospital | Thessaloniki | Thessaloníki | 570 10 | Greece | Details | |
| Hong Kong United Oncology Centre | Jordan | Kowloon | 999077 | Hong Kong | Details | |
| Prince of Wales Hospital | Shatin | 852 | Hong Kong | Details | ||
| Soroka Medical Center | Beer-Sheva | 8400000 | Israel | Details | ||
| Shaare Zedek Medical Center | Jerusalem | 9103102 | Israel | Details | ||
| Hadassah Medical Center | Jerusalem | 9112001 | Israel | Details | ||
| Sheba Medical Center | Ramat Gan | 5262100 | Israel | Details | ||
| Rambam Health Care Campus | Haifa | Ḥeifā | 3109601 | Israel | Details | |
| Istituto Nazionale Tumori IRCCS Fondazione Pascale | Napoli | Campania | 80131 | Italy | Details | |
| Ospedale Santa Maria delle Croci | Ravenna | Emilia-Romagna | 48121 | Italy | Details | |
| Cro-Irccs | Aviano | Friuli-Venezia Giulia | 33081 | Italy | Details | |
| Azienda Ospedaliera San Camillo Forlanini | Roma | Lazio | 00152 | Italy | Details | |
| Fondazione Policlinico Universitario Agostino Gemelli | Roma | Lazio | 00168 | Italy | Details | |
| Ospedale San Gerardo-ASST Monza | Monza | Lombardia | 20900 | Italy | Details | |
| ASST Grande Ospedale Metropolitano Niguarda | Milan | Milano | 20162 | Italy | Details | |
| Humanitas | Rozzano | Milano | 20089 | Italy | Details | |
| Azienda Sanitaria Ospedaliera S Luigi Gonzaga | Orbassano | Torino | 10043 | Italy | Details | |
| Azienda Ospedaliera San Giuseppe Moscati | Avellino | 83100 | Italy | Details | ||
| IRCCS - AOU di Bologna | Bologna | 40138 | Italy | Details | ||
| Azienda Ospedaliera Universitaria Pisana | Pisa | 56126 | Italy | Details | ||
| Istituto Nazionale Tumori Regina Elena | Roma | 00144 | Italy | Details | ||
| National Cancer Center Hospital East | Kashiwa | Chiba | 277-8577 | Japan | Details | |
| National Hospital Organization Hokkaido Cancer Center | Sapporo | Hokkaido | 003-0804 | Japan | Details | |
| Kanazawa University Hospital | Kanazawa | Ishikawa | 920-8641 | Japan | Details | |
| Kanagawa cancer center | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Kindai University Hospital- Osakasayama Campus | Osaka Sayama-shi | Osaka | 589 8511 | Japan | Details | |
| Tominaga Hospital | Nagaizumi | Shizuoka | 411-8777 | Japan | Details | |
| National Cancer Center Hospital | Chuo-ku | Tokyo | 104-0045 | Japan | Details | |
| Japanese Foundation for Cancer Research | Koto | Tokyo | 135-8550 | Japan | Details | |
| Tottori University Hospital | Yonago | Tottori | 683-8504 | Japan | Details | |
| Okayama University Hospital | Okayama | 700-8558 | Japan | Details | ||
| Osaka International Cancer Institute | Osaka | 541-8567 | Japan | Details | ||
| National Cancer Center | Goyang-si | Gyeonggi-do | 10408 | Korea, Republic of | Details | |
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 13620 | Korea, Republic of | Details | |
| Gachon University Gil Medical Center | Incheon | Korea | 21565 | Korea, Republic of | Details | |
| Asan Medical Center | Seoul | Korea | 05505 | Korea, Republic of | Details | |
| Gyeongsang National University Hospital | Jin-ju-si | Kyǒngsangnam-do | 52727 | Korea, Republic of | Details | |
| Seoul National University Hospital | Seoul | Seoul, Korea | 03080 | Korea, Republic of | Details | |
| Boramae Medical Center | Dongjak-gu | Seoul-teukbyeolsi [Seoul] | 07061 | Korea, Republic of | Details | |
| Konyang University Hospital | Daejon | 35365 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| Health Pharma Professional Research S.A. de C.V: | Mexico City | Federal District | 03100 | Mexico | Details | |
| Actualidad Basada en la Investigación del Cáncer | Guadalajara | Jalisco | 44680 | Mexico | Details | |
| Oncologico Potosino, S.C. | San Luis Potosí | 78209 | Mexico | Details | ||
| Ziekenhuis St. Jansdal | Harderwijk | Gelderland | 3844 DG | Netherlands | Details | |
| Jeroen Bosch ziekenhuis | Den Bosch | Noord-Brabant | 5223 GZ | Netherlands | Details | |
| Erasmus Medisch Centrum | Rotterdam | Zuid-Holland | 3015 CE | Netherlands | Details | |
| Amsterdam UMC, locatie VUmc | Amsterdam | 1081 HV | Netherlands | Details | ||
| Uniwersyteckie Centrum Kliniczne | Gdansk | 80-952 | Poland | Details | ||
| Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy | Warszawa | 02-781 | Poland | Details | ||
| Institutul Oncologic | Bucharest | București | 22328 | Romania | Details | |
| Gral Medical Diagnostic Center | Bucuresti | București | 031422 | Romania | Details | |
| Constanta County Emergency Clinical Hospital Sf.Ap.Andrei | Constanta | Constanța | 900591 | Romania | Details | |
| Cabinet Medical Oncomed | Timișoara | Timiș | 300239 | Romania | Details | |
| Spitalul Universitar de Urgență București | Bucuresti | 050098 | Romania | Details | ||
| Institutul Oncologic | Cluj-Napoca | 400015 | Romania | Details | ||
| Spitalul Județean Sfântul Ioan cel Nou Suceava | Suceava | 720237 | Romania | Details | ||
| GBUZ Republican Clinical Oncological Dispensary | Ufa | Baškortostan, Respublika | 450054 | Russian Federation | Details | |
| Kaluga Regional Clinical Oncology Center | Kaluga | Kalužskaja Oblast | 248007 | Russian Federation | Details | |
| Murmansk Regional Clinical Hospital P.A. Bayandina | Murmansk | Murmanskaya Oblast' | 183047 | Russian Federation | Details | |
| Samara Regional Clinical Oncology Center | Samara | Samarskaya Oblast' | 443031 | Russian Federation | Details | |
| Scientific research institution of oncology named after N.N. Petrov | Saint Petersburg | Sankt-Peterburg | 197758 | Russian Federation | Details | |
| Saint-Petersburg Scientific-Practical Center of Specialized Kinds of Medical Care (oncological) named afte -T | St. Petersburg | Sankt-Peterburg | 197758 | Russian Federation | Details | |
| Arkhangelsk Clinical Oncological Dispensary | Arkhangelsk | 163045 | Russian Federation | Details | ||
| Republican Clinical Oncology Dispensary | Kazan | 420029 | Russian Federation | Details | ||
| First Moscow State Medical University I.M. Sechenov | Moscow | 119991 | Russian Federation | Details | ||
| Hadassah Medical | Moscow | 121205 | Russian Federation | Details | ||
| Tan Tock Seng Hospital | Singapore | 308433 | Singapore | Details | ||
| Hospital Fundacion Son Llatzer | Palma de Mallorca | Baleares | 07198 | Spain | Details | |
| Institut Català d'Oncologia (ICO) - Badalona | Badalona | Barcelona [Barcelona] | 08916 | Spain | Details | |
| CHUS - Hospital Clinico Universitario | Santiago de Compostela | Galicia [Galicia] | 15706 | Spain | Details | |
| Hospital Insular de Gran Canaria | Las palmas de gran canaria | Las Palmas | 35016 | Spain | Details | |
| Hospital Universitario Puerta de Hierro Majadahonda | Majadahonda | Madrid | 28222 | Spain | Details | |
| Clinica Universitaria De Navarra | Pamplona | Navarra | 31008 | Spain | Details | |
| Hospital General Universitario de Alicante | Alicante | 03010 | Spain | Details | ||
| Parc de Salut Mar - Hospital del Mar | Barcelona | 08003 | Spain | Details | ||
| Hospital Universitari Dexeus | Barcelona | 08028 | Spain | Details | ||
| Instituto Catalan de Oncologia - Hospital Duran i Reynals | Barcelona | 08908 | Spain | Details | ||
| Hospital de la Santa Creu i Sant Pau | Barcelona | 8041 | Spain | Details | ||
| Complejo Hospitalario de Jaén | Jaén | 23007 | Spain | Details | ||
| Clinica Universidad de Navarra | Madrid | 28027 | Spain | Details | ||
| Hospital Universitario Ramón y Cajal | Madrid | 28034 | Spain | Details | ||
| Hospital Clinico San Carlos | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario 12 de Octubre | Madrid | 28041 | Spain | Details | ||
| Hospital Universitario La Paz | Madrid | 28046 | Spain | Details | ||
| Hospital Regional Universitario | Malaga | 29011 | Spain | Details | ||
| Complejo Hospitalario de Navarra | Pamplona | 31009 | Spain | Details | ||
| Hospital Universitario Virgen Macarena | Sevilla | 41009 | Spain | Details | ||
| Hospital Universitario Virgen Del Rocio | Sevilla | 41013 | Spain | Details | ||
| Hospital Clínico Universitario de Valencia | Valencia | 46010 | Spain | Details | ||
| Hospital Universitari i Politecnic La Fe | Valencia | 46026 | Spain | Details | ||
| Changhua Christian Hospital | Changhua County | Changhua | 50006 | Taiwan | Details | |
| Buddhist Dalin Tzu Chi General Hospital | Dalin Town | Chiayi | 622 | Taiwan | Details | |
| Chang Gung Memorial Hospital - Linkou | Guei Shan Township | Taoyuan County | 333 | Taiwan | Details | |
| E-Da hospital | Kaohsiung | 82445 | Taiwan | Details | ||
| Chang Gung Memorial Hospital at Kaohsiung | Kaohsiung | 83301 | Taiwan | Details | ||
| Tri-Service General Hospital | Neihu Taipei | 114 | Taiwan | Details | ||
| Taipei Medical University Shuang Ho Hospital | New Taipei | 235 | Taiwan | Details | ||
| Chung Shan Medical University Hospital | Taichung | 402 | Taiwan | Details | ||
| China Medical University Hospital | Taichung | 40447 | Taiwan | Details | ||
| Taichung Veterans General Hospital | Taichung | 407 | Taiwan | Details | ||
| Chi Mei Hospital - Liouying Branch | Tainan City | 73657 | Taiwan | Details | ||
| National Cheng-Kung Uni. Hosp. | Tainan | 704 | Taiwan | Details | ||
| National Taiwan University Hospital | Taipei City | 10048 | Taiwan | Details | ||
| Taipei Veterans General Hospital | Taipei | 11217 | Taiwan | Details | ||
| Ege Universitesi Hastanesi | Bornova | İzmir | 35100 | Turkey | Details | |
| Baskent University Dr. Turgut Noyan Research and Training Center | Adana | 1250 | Turkey | Details | ||
| Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi | Ankara | 6200 | Turkey | Details | ||
| Hacettepe University Faculty of Medicine | Ankara | 6230 | Turkey | Details | ||
| Memorial Antalya Hastanesi | Antalya | 7090 | Turkey | Details | ||
| Dicle Üniversitesi | Diyarbakir | 21100 | Turkey | Details | ||
| Trakya University | Edirne | 22030 | Turkey | Details | ||
| Istanbul Medeniyet University | Istanbul | 34722 | Turkey | Details | ||
| zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi | Izmir | 35360 | Turkey | Details | ||
| Izmir Medical Park Hospital | Izmir | 9035575 | Turkey | Details | ||
| Inonu Universitesi Turgut Ozal Tıp Merkezi | Malatya | 44280 | Turkey | Details | ||
| Acıbadem Maslak Hastanesi | Sarıyer | 34457 | Turkey | Details | ||
| Municipal Non-profit Enterprise "City Clinical Hospital #4" of Dnipro City Council, "Dnipro State Medical University" | Dnipro | Dnipropetrovska Oblast | 49102 | Ukraine | Details | |
| CNPE "Regional Center of Oncology" | Kharkiv | Kharkivska Oblast | 61070 | Ukraine | Details | |
| Odessa Regional Oncology Center | Odesa | Odeska Oblast | 65055 | Ukraine | Details | |
| Sumy regional clinical oncological dispensary | Sumy | Sumska Oblast | 40022 | Ukraine | Details | |
| Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council" | Vinnytsia | Vinnytska Oblast | 21029 | Ukraine | Details | |
| Municipal Enterprise "Volyn Regional Medical Oncology Centre" of the Volyn Regional Council | Lutsk | Volynska Oblast | 43018 | Ukraine | Details | |
| "Oncolife" LLC | Zaporizhya | Zaporizka Oblast | 69059 | Ukraine | Details | |
| Regional Municipal Non-profit Enterprise "Bukovinian Clinical Oncology Center" | Chernivtsi | 58013 | Ukraine | Details | ||
| Medical Center "Mriya Med-Service", LLC | Kryvyi Rig | 50000 | Ukraine | Details | ||
| Municipal non-profit enterprise "Kyiv City Clinical Oncology Center" of executive body of Kyiv City Counci -T | Kyiv | 03115 | Ukraine | Details | ||
| Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council | Odesa | 65025 | Ukraine | Details | ||
| City Hospital, Nottingham University Hospitals | Nottingham | Nottinghamshire | NG5 1PB | United Kingdom | Details |