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| NCT ID | NCT04662255 |
| Title | Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL) (BRUIN-MCL-321) |
| Acronym | BRUIN-MCL-321 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Loxo Oncology, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | POL | NZL | NLD | ITA | ISR | IRL | HUN | GBR | FRA | ESP | DNK | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Alaska Oncology & Hematology, LLC | Anchorage | Alaska | 99508 | United States | Details | |
| Arizona Oncology Associates, P.C. - HOPE | Phoenix | Arizona | 85016 | United States | Details | |
| Arizona Oncology Associates, P.C. - HOPE | Tucson | Arizona | 85711 | United States | Details | |
| St. Joseph Heritage Healthcare | Fullerton | California | 92835 | United States | Details | |
| The Oncology Institute of Hope and Innovation | Long Beach | California | 90805 | United States | Details | |
| UCLA Medical Center | Los Angeles | California | 90095 | United States | Details | |
| Rocky Mountain Cancer Center | Aurora | Colorado | 80012 | United States | Details | |
| Medical Oncology Hematology Consultants, PA | Newark | Delaware | 19713 | United States | Details | |
| Florida Cancer Specialists | Fort Myers | Florida | 33901 | United States | Details | |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224 | United States | Details | |
| Florida Cancer Specialists | Saint Petersburg | Florida | 33705 | United States | Details | |
| Florida Cancer Specialists | Tallahassee | Florida | 32308 | United States | Details | |
| Oncology-Hematology Associates of West Broward | Tamarac | Florida | 33321 | United States | Details | |
| Florida Cancer Specialists East | West Palm Beach | Florida | 33401 | United States | Details | |
| University of Kentucky Markey Cancer Center | Lexington | Kentucky | 40504 | United States | Details | |
| Mercy Health-Paducah Medical Oncology and Hematology | Paducah | Kentucky | 42003 | United States | Details | |
| Hematology Oncology Clinic | Baton Rouge | Louisiana | 70809 | United States | Details | |
| Cancer Center Office of Clinical Research | New Orleans | Louisiana | 70112 | United States | Details | |
| Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | 21201 | United States | Details | |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | United States | Details | |
| University of Michigan | Ann Arbor | Michigan | 48109 | United States | Details | |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | United States | Details | |
| Mayo Clinic | Rochester | Minnesota | 55905 | United States | Details | |
| Health Midwest Ventures Group, Inc d/b/a HCA MidAmerica Division, LLC | Kansas City | Missouri | 64132 | United States | Details | |
| Washington University Medical School | Saint Louis | Missouri | 63110 | United States | Details | |
| University of Nebraska Medical Center | Omaha | Nebraska | 68105 | United States | Details | |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89169 | United States | Details | |
| Hematology Oncology Associates Of Northern New Jersey | Morristown | New Jersey | 07960 | United States | Details | |
| Columbia University Medical Center | New York | New York | 10032 | United States | Details | |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States | Details | |
| New York Medical College | New York | New York | 10532 | United States | Details | |
| Messino Cancer Center | Asheville | North Carolina | 28806 | United States | Details | |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | United States | Details | |
| Wake Forest University School of Medicine | Winston-Salem | North Carolina | 27157 | United States | Details | |
| Oncology Hematology Care Inc | Cincinnati | Ohio | 45236 | United States | Details | |
| Willamette Valley Cancer Institute & Research Ctr. | Eugene | Oregon | 97401 | United States | Details | |
| Oregon Oncology Specialists | Salem | Oregon | 97301 | United States | Details | |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15213 | United States | Details | |
| Sarah Cannon Research Institute SCRI | Nashville | Tennessee | 37203 | United States | Details | |
| Texas Oncology-Austin Midtown | Austin | Texas | 78705 | United States | Details | |
| Texas Oncology - Bedford | Bedford | Texas | 76022 | United States | Details | |
| Texas Oncology - Bayler Charles A. Sammons Cancer Center | Houston | Texas | 75246 | United States | Details | |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Texas Oncology - McAllen | McAllen | Texas | 78503 | United States | Details | |
| Texas Oncology - McKinney | McKinney | Texas | 75071 | United States | Details | |
| Texas Oncology - Sherman | Sherman | Texas | 75090 | United States | Details | |
| Texas Oncology - Tyler | Tyler | Texas | 75702 | United States | Details | |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | United States | Details | |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22908 | United States | Details | |
| Virginia Cancer Specialists, PC | Gainesville | Virginia | 20155 | United States | Details | |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | United States | Details | |
| University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | 53705 | United States | Details | |
| Froedtert Memorial Lutheran Hospital | Milwaukee | Wisconsin | 53226 | United States | Details | |
| The St. George Hospital | Kogarah | New South Wales | 2217 | Australia | Details | |
| Flinders Medical Centre | Adelaide | South Australia | 5042 | Australia | Details | |
| Royal Hobart Hospital | Hobart | Tasmania | 7000 | Australia | Details | |
| Andrew Lowe Cancer Centre | Geelong | Victoria | 3220 | Australia | Details | |
| Linear Clinical Research Ltd | Nedlands | Western Australia | WA6009 | Australia | Details | |
| Royal Perth Hospital | Perth | Western Australia | 6000 | Australia | Details | |
| Icon Cancer Care - The Wesley Medical Centre | Auchenflower | 4066 | Australia | Details | ||
| Ordensklinikum Linz GmbH Elisabethinen | Linz | Oberösterreich | 4020 | Austria | Details | |
| Uniklinikum Salzburg | Salzburg | Osterreich | 5020 | Austria | Details | |
| Universitair Ziekenhuis Gent | Gent | 9000 | Belgium | Details | ||
| Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg | Leuven | 3000 | Belgium | Details | ||
| AZ Delta | Roeselare | 8800 | Belgium | Details | ||
| NOHC- Nucleo de Oncologia e Hematologia do Ceara e Oncovie | Fortaleza | Ceará | 60115-281 | Brazil | Details | |
| HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás | Goiânia | Goiás | 74605-020 | Brazil | Details | |
| Hospital Sao Domingos | São Luís | Maranhão | 65060-645 | Brazil | Details | |
| HC-UFPR- Hospital de Clinicas da Universidade Federal do Parana | Curitiba | Paraná | 80060-900 | Brazil | Details | |
| HMCP - Hospital e Maternidade Celso Pierro - PUC-Campinas | Campinas | Sao Paulo | 13060-904 | Brazil | Details | |
| CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia | Santo Andre | Sao Paulo | 09060-870 | Brazil | Details | |
| Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto | São José Do Rio Preto | São Paulo | 15090-000 | Brazil | Details | |
| INCA - Instituto Nacional de Cancer | Rio De Janeiro | 20231-050 | Brazil | Details | ||
| Hospital Sao Lucas Copacabana | Rio de Janeiro | 22061-080 | Brazil | Details | ||
| IEP - Instituto de Ensino e Pesquisas São Lucas | Sao Paulo | 01236-030 | Brazil | Details | ||
| Irmandade da Santa Casa de Misericordia de Sao Paulo | São Paulo | 01221-010 | Brazil | Details | ||
| BP A Beneficencia Portuguesa da Sao Paulo | São Paulo | 01323-001 | Brazil | Details | ||
| A. C. Camargo Cancer Center | São Paulo | 01509-010 | Brazil | Details | ||
| HC-FMUSP | São Paulo | 05403-010 | Brazil | Details | ||
| Albert Einstein Sociedade Beneficente Israelita Brasileira | São Paulo | 05652-900 | Brazil | Details | ||
| Hospital Nove de Julho | São Paulo | 1409902 | Brazil | Details | ||
| Cross Cancer Institute | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| BC Cancer Vancouver | Vancouver | British Columbia | V5Z 1H6 | Canada | Details | |
| CancerCare Manitoba | Winnipeg | Manitoba | R3A 1M3 | Canada | Details | |
| Princess Margaret Cancer Centre | Toronto | Ontario | M4X 1K9 | Canada | Details | |
| Anhui Provincial Cancer Hospital | Hefei | Anhui | 233004 | China | Details | |
| Peking University First Hospital | Beijing | Beijing | 100034 | China | Details | |
| Peking University People's Hospital | Beijing | Beijing | 100044 | China | Details | |
| Beijing Chaoyang Hospital, Capital Medical University | Beijing | Beijing | 100141 | China | Details | |
| Peking University Third Hospital | Beijing | Beijing | 100191 | China | Details | |
| Beijing Cancer hospital | Haidian District | Beijing | 100142 | China | Details | |
| Fujian Cancer Hospital | Fuzhou | Fujian | 350014 | China | Details | |
| Cancer Center of Guangzhou Medical University | Guangzhou | Guangdong | 510000 | China | Details | |
| Sun Yat-sen University Cancer Center | Guangzhou | Guangdong | 510060 | China | Details | |
| Southern Medical University Nanfang Hospital | Guangzhou | Guangdong | 510515 | China | Details | |
| The First Affiliated Hospital of Henan Science and Technology University | Luoyang | Henan | 471003 | China | Details | |
| Henan Cancer Hospital | Zhengzhou | Henan | 450008 | China | Details | |
| Wuhan Union Hospital | Wuhan | Hubei | 430022 | China | Details | |
| Yichang Central People's Hospital | Yichang | Hubei | 443003 | China | Details | |
| Hunan Cancer Hospital | Changsha | Hunan | 410013 | China | Details | |
| The First Affiliated Hospital of Soochow University | Suzhou | Jiangsu | 215066 | China | Details | |
| The First Affiliated Hospital of Nanchang University | Nanchang | Jiangxi | 330006 | China | Details | |
| Jilin Cancer Hospital | Changchun | Jilin | 410013 | China | Details | |
| Shengjing Hospital of China Medical University | Shenyang | Liaoning | 110004 | China | Details | |
| West China Hospital of Sichuan University | Chengdu | Sichuan | 610041 | China | Details | |
| Tianjin Medical University Cancer Institute and Hospital | Tianjin | Tianjin | 300060 | China | Details | |
| Affiliated Tumor Hospital of Xinjiang Medical University | Urumqi | Xinjiang | 830002 | China | Details | |
| Zhejiang Cancer Hospital | Hangzhou | Zhejiang | 310022 | China | Details | |
| Lishui Municipal Central Hospital | Lishui | Zhejiang | 323000 | China | Details | |
| Chongqing Cancer Hospital | Chongqing | 400030 | China | Details | ||
| Fudan University Shanghai Cancer Center | Shanghai | 200032 | China | Details | ||
| Blood Institute of the Chinese Academy of Medical science | Tianjin | 300020 | China | Details | ||
| Fakultni nemocnice Brno | Brno | 62500 | Czechia | Details | ||
| Fakultni nemocnice Hradec Kralove | Hradec Kralove | 500 05 | Czechia | Details | ||
| Aarhus Universitetshospital, Aarhus Sygehus | Aarhus N | Jutland | DK-8200 | Denmark | Details | |
| Odense Universitetshospital | Odense | DK-5000 | Denmark | Details | ||
| Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest | Bordeaux | Aquitaine | 33076 | France | Details | |
| Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen | Rouen | Seine-Maritime | 76038 | France | Details | |
| CHRU De Tours | Tours | Tours Cedex 9 | 37044 | France | Details | |
| Hopital Saint Vincent De Paul | Lille cedex | 59020 | France | Details | ||
| Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu | Nantes Cedex 1 | 44093 | France | Details | ||
| Groupe Hospitalier Pitie-Salpetriere | Paris | 75013 | France | Details | ||
| Centre hospitalier universitaire de Haut Leveque | Pessac Cedex | 33600 | France | Details | ||
| Centre Hospitalier Lyon Sud | Pierre Benite Cedex | 69495 | France | Details | ||
| Pole Regionalde Cancérologie(CHU de Poitiers) | Politiers | 86021 | France | Details | ||
| Chu De Nancy Hop D'Adultes De Brabois | Vandœuvre-lès-Nancy | 54500 | France | Details | ||
| Institut Curie | Saint-Cloud | Île-de-France | 92210 | France | Details | |
| Universitätsklinikum Ulm | Ulm | Baden-Württemberg | 89081 | Germany | Details | |
| Klinikum der Universität München Großhadern | München | Bayern | 81377 | Germany | Details | |
| Universitaetsklinikum Muenster | Münster | Nordrhein-Westfalen | 48149 | Germany | Details | |
| InVO - Institut für Versorgungsforschung in der Onkologie GbR | Koblenz | Rhineland-Palatinate | 65068 | Germany | Details | |
| Universitaetsklinikum Schleswig-Holstein - Campus Kiel | Kiel | Schleswig Holstein | 24105 | Germany | Details | |
| OncoResearch Lerchenfeld GmbH | Hamburg | 22081 | Germany | Details | ||
| Universitätsmedizin Johannes Gutenberg Universität Mainz | Mainz | 55131 | Germany | Details | ||
| Universitaetsklinikum Muenster | Munster | 48149 | Germany | Details | ||
| Pecsi Tudomanyegyetem Klinikai Kozpont | Pécs | Baranya | 7632 | Hungary | Details | |
| Debreceni Egyetem | Debrecen | 4032 | Hungary | Details | ||
| St James's Hosptial | Dublin | Dublin 8 | D08 NHY1 | Ireland | Details | |
| Bnai Zion Medical Center | Haifa | 3339419 | Israel | Details | ||
| Hadassah Medical Center | Jerusalem | 9112001 | Israel | Details | ||
| Chaim Sheba Medical Center | Ramat Gan | Israel | Details | |||
| Tel Aviv Sourasky Medical Center | Tel Aviv | 6423906 | Israel | Details | ||
| Presidio Ospedaliero Civile Santi Antonio e Biagio | Alessandria | AL | 15100 | Italy | Details | |
| Azienda Ospedaliero Universitaria Ospedali Riuniti | Torrette | Ancona | 60020 | Italy | Details | |
| Irccs Istituto Tumori Giovanni Paolo Ii | Viale Orazio Flacco | Bari | 70124 | Italy | Details | |
| Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori | Meldola | Emilia-Romagna | 47014 | Italy | Details | |
| Ospedale San Raffaele | Milano | Lombardia | 20132 | Italy | Details | |
| Irccs Crob | Rionero in Vulture | Potenza | 85028 | Italy | Details | |
| IRCCS - AOU di Bologna | Bologna | 40138 | Italy | Details | ||
| IRCCS Ospedale Policlinico San Martino | Genova | 16132 | Italy | Details | ||
| Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte | Messina | 98158 | Italy | Details | ||
| Ospedale Vincenzo Cervello | Palermo | 90100 | Italy | Details | ||
| Azienda Ospedaliero Universitaria Pisana | Pisa | 56126 | Italy | Details | ||
| Ospedale Santa Maria delle Croci | Ravenna | 48020 | Italy | Details | ||
| Arcispedale Santa Maria Nuova | Reggio Emilia | 42123 | Italy | Details | ||
| Ospedale di Circolo e Fondazione Macchi Varese | Varese | 21100 | Italy | Details | ||
| Nagoya Medical Center | Nagoya | Aichi | 460-0001 | Japan | Details | |
| Nagoya City University Hospital | Nagoya | Aichi | 467-8602 | Japan | Details | |
| Hokkaido University Hospital | Sapporo | Hokkaido | 060-8648 | Japan | Details | |
| Kobe City Medical Center General Hospital | Kobe | Hyogo | 650-0047 | Japan | Details | |
| Kochi Medical School Hospital | Nankoku | Kochi | 783-8505 | Japan | Details | |
| Tohoku University Hospital | Sendai-shi | Miyagi | 980-8574 | Japan | Details | |
| Kindai University Hospital | Osaka Sayama-shi | Osaka | 589 8511 | Japan | Details | |
| Saitama Medical Center | Kawagoe | Saitama | 350-8550 | Japan | Details | |
| Japanese Foundation for Cancer Research | Koto | Tokyo | 135-8550 | Japan | Details | |
| NTT Medical Center Tokyo | Shinagawa-KU | Tokyo | 141-8625 | Japan | Details | |
| Chugoku Central Hospital | Hiroshima | 720-0001 | Japan | Details | ||
| Kumamoto University Hospital | Kumamoto | 860-8556 | Japan | Details | ||
| Kyoto Furitsu Medical University Hospital | Kyoto-shi | 602 8566 | Japan | Details | ||
| Okayama University Hospital | Okayama | 700-8558 | Japan | Details | ||
| Gachon University Gil Hospital | Namdong-gu | Incheon-gwangyeoksi [Incheon] | 21565 | Korea, Republic of | Details | |
| Kosin University Gospel Hospital | Busan | Seogu | 49267 | Korea, Republic of | Details | |
| Seoul National University Hospital | Seoul | Seoul, Korea | 03080 | Korea, Republic of | Details | |
| Severance Hospital, Yonsei University Health System | Seoul | Seoul-teukbyeolsi [Seoul] | 03722 | Korea, Republic of | Details | |
| Asan Medical Center | Seoul | Seoul-teukbyeolsi [Seoul] | 05505 | Korea, Republic of | Details | |
| Samsung Medical Center | Seoul | Seoul-teukbyeolsi [Seoul] | 06351 | Korea, Republic of | Details | |
| The Catholic University of Korea-Seoul St. Mary's Hospital | Seocho-Gu | Seoul | 06591 | Korea, Republic of | Details | |
| Inje Univ Busan Paik Hospital | Busan | 47392 | Korea, Republic of | Details | ||
| Ziekenhuisapotheek HagaZiekenhuis | Den Haag | 2545 AA | Netherlands | Details | ||
| Bravis Ziekenhuis | Roosendaal | 4708 AE | Netherlands | Details | ||
| Erasmus Medisch Centrum | Rotterdam | 3015 AA | Netherlands | Details | ||
| Spaarne Gasthuis | TM Hoofddorp | 2134 | Netherlands | Details | ||
| Middlemore Clinical Trials | Papatoetoe | Auckland | 2025 | New Zealand | Details | |
| Christchurch Hospital | Christchurch | 8011 | New Zealand | Details | ||
| Centrum Onkologii Ziemi Lubelskiej | Lublin | Lubelskie | 20-081 | Poland | Details | |
| Uniwersyteckie Centrum Kliniczne | Gdańsk | Pomorskie | 80-214 | Poland | Details | |
| Pratia MCM Krakow | Krakow | 30-510 | Poland | Details | ||
| Centrum Medyczne Pratia Poznań | Skórzewo | 60-185 | Poland | Details | ||
| Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu | Wroclaw | 50-367 | Poland | Details | ||
| Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii | Łódź | 93510 | Poland | Details | ||
| IPOFG - Lisboa | Lisboa | 1099-035 | Portugal | Details | ||
| Champalimaud Foundation | Lisboa | 1400-038 | Portugal | Details | ||
| Budgetary Healthcare Institution of Omsk Region "Clinical Oncology Dispensary" | Omsk | Omskaya Oblast' | 644013 | Russian Federation | Details | |
| GUZ of Moscow City Clinical Hospital n.a. S.P. Botkin | Moscow | 125101 | Russian Federation | Details | ||
| Federal State Budgetary Institution "Russian Scientific and Research Institute of Hematology and Transfusiology of Federal Medico-Biological Agency | Saint Petersburg | 191024 | Russian Federation | Details | ||
| State Medical University named after I.P. Pavlov | Saint-Petersburg | 197022 | Russian Federation | Details | ||
| Hospital Universitario Virgen de la Victoria | Malaga | Andalucia | 29010 | Spain | Details | |
| Hospital Duran I Reynals | Hospitalet De Llobregat | Barcelona | 08908 | Spain | Details | |
| Complejo Hospitalario Universitario de Santiago | A Coruña | 15706 | Spain | Details | ||
| Hospital Universitari Vall d'Hebron | Barcelona | 08035 | Spain | Details | ||
| Hospital Clinic de Barcelona | Barcelona | 08036 | Spain | Details | ||
| Hospital General Universitario Gregorio Marañon | Madrid | 28007 | Spain | Details | ||
| Hospital Infanta Leonor | Madrid | 28031 | Spain | Details | ||
| Hospital Universitario Fundación Jiménez Díaz | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario 12 de Octubre | Madrid | 28041 | Spain | Details | ||
| Clinica Universidad de Navarra | Pamplona | 31008 | Spain | Details | ||
| Hospital Universitario Virgen Macarena | Sevilla | 41009 | Spain | Details | ||
| Hospital Clinico Universitario de Valencia | Valencia | 46010 | Spain | Details | ||
| Kantonsspital Luzern | Luzern 16 | Luzern | 6000 | Switzerland | Details | |
| Ospedale Regionale Bellinzona e Valli | Bellinzona | CH-6500 | Switzerland | Details | ||
| Tri-Service General Hospital | Taipei City | Taipei | 114 | Taiwan | Details | |
| Chang Gung Memorial Hospital - Chiayi | Chiayi County | 61363 | Taiwan | Details | ||
| Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung | 80756 | Taiwan | Details | ||
| China Medical University Hospital | Taichung | 40447 | Taiwan | Details | ||
| National Cheng Kung University Hospital | Tainan | 704 | Taiwan | Details | ||
| National Taiwan University Hospital | Taipei | 10002 | Taiwan | Details | ||
| Taipei Veterans General Hospital | Taipei | 11217 | Taiwan | Details | ||
| Chang Gung Memorial Hospital - Linkou | Taoyuan City | 333 | Taiwan | Details | ||
| Aberdeen Royal Infirmary | Aberdeen | Aberdeen City | AB25 2ZN | United Kingdom | Details | |
| Churchill Hospital | Headington | Oxford | OX3 7LE | United Kingdom | Details | |
| Beatson West of Scotland Cancer Centre | Glasgow | Stratchclyde | G12OYN | United Kingdom | Details | |
| Royal Marsden Hospital | Sutton | Surrey | SM2 5PT | United Kingdom | Details | |
| GenesisCare Cambridge | Newmarket | CB8 7XN | United Kingdom | Details | ||
| City Hospital, Nottingham University Hospitals | Nottingham | NG5 1PB | United Kingdom | Details | ||
| Derriford Hospital | Plymouth | Pl6 8DH | United Kingdom | Details | ||
| GenesisCare, Windsor | Windsor | SL4 3HD | United Kingdom | Details | ||
| New Cross Hospital | Wolverhampton | WV10 0QP | United Kingdom | Details |