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| NCT ID | NCT04915755 |
| Title | Efficacy and Safety Comparison of Niraparib to Placebo in Participants With Human Epidermal Growth Factor 2 Negative (HER2-) Breast Cancer Susceptibility Gene Mutation (BRCAmut) or Triple-Negative Breast Cancer (TNBC) With Molecular Disease (ZEST) |
| Acronym | ZEST |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | GlaxoSmithKline |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | ROU | POL | NOR | NLD | ITA | ISR | IRL | HUN | GBR | FRA | FIN | ESP | DEU | CHE | CAN | BRA | BEL | AUT | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| GSK Investigational Site | Burbank | California | 91505 | United States | Details | |
| GSK Investigational Site | Duarte | California | 91010 | United States | Details | |
| GSK Investigational Site | Orange | California | 92868 | United States | Details | |
| GSK Investigational Site | Palo Alto | California | 94304 | United States | Details | |
| GSK Investigational Site | San Francisco | California | 94158 | United States | Details | |
| GSK Investigational Site | Aurora | Colorado | 80045 | United States | Details | |
| GSK Investigational Site | Chicago | Illinois | 60612 | United States | Details | |
| GSK Investigational Site | Skokie | Illinois | 60076 | United States | Details | |
| GSK Investigational Site | Ann Arbor | Michigan | 48109 | United States | Details | |
| GSK Investigational Site | Albuquerque | New Mexico | 87106 | United States | Details | |
| GSK Investigational Site | New York | New York | 10032 | United States | Details | |
| GSK Investigational Site | Fargo | North Dakota | 58122 | United States | Details | |
| GSK Investigational Site | Philadelphia | Pennsylvania | 19111 | United States | Details | |
| GSK Investigational Site | Pittsburgh | Pennsylvania | 15213 | United States | Details | |
| GSK Investigational Site | Sioux Falls | South Dakota | 57104 | United States | Details | |
| GSK Investigational Site | Austin | Texas | 78731 | United States | Details | |
| GSK Investigational Site | Dallas | Texas | 75231 | United States | Details | |
| GSK Investigational Site | Dallas | Texas | 75246 | United States | Details | |
| GSK Investigational Site | Fort Worth | Texas | 76104 | United States | Details | |
| GSK Investigational Site | Houston | Texas | 77024 | United States | Details | |
| GSK Investigational Site | San Antonio | Texas | 78240 | United States | Details | |
| GSK Investigational Site | Tyler | Texas | 75702 | United States | Details | |
| GSK Investigational Site | Norfolk | Virginia | 23502 | United States | Details | |
| GSK Investigational Site | Everett | Washington | 98201 | United States | Details | |
| GSK Investigational Site | Capital Federal | Buenos Aires | C1426ANZ | Argentina | Details | |
| GSK Investigational Site | Ciudad Autonoma Buenos Aires | Buenos Aires | C1430EGF | Argentina | Details | |
| GSK Investigational Site | Ciudad Autónoma de Buenos Aires | Buenos Aires | C1125ABD | Argentina | Details | |
| GSK Investigational Site | Gualeguaychu | Entre Ríos | 2822 | Argentina | Details | |
| GSK Investigational Site | Cipoletti, Rio Negro | Río Negro | R8324CVE | Argentina | Details | |
| GSK Investigational Site | Buenos Aires | C1426AGE | Argentina | Details | ||
| GSK Investigational Site | Capital Federal, Buenos Aires | C1118AAT | Argentina | Details | ||
| GSK Investigational Site | Ciudad Autonoma Buenos Aires | C1015ABO | Argentina | Details | ||
| GSK Investigational Site | Ciudad Autonoma de Buenos Aires | C1017 AAS | Argentina | Details | ||
| GSK Investigational Site | Ciudad Autónoma de Buenos Aires | C1426ABP | Argentina | Details | ||
| GSK Investigational Site | Camperdown | New South Wales | 2050 | Australia | Details | |
| GSK Investigational Site | Macquarie University | New South Wales | 2109 | Australia | Details | |
| GSK Investigational Site | North Sydney | New South Wales | 2060 | Australia | Details | |
| GSK Investigational Site | Innsbruck | 6020 | Austria | Details | ||
| GSK Investigational Site | Rankweil | A-6830 | Austria | Details | ||
| GSK Investigational Site | Steyr | 4400 | Austria | Details | ||
| GSK Investigational Site | Wien | A-1090 | Austria | Details | ||
| GSK Investigational Site | Brussels | 1200 | Belgium | Details | ||
| GSK Investigational Site | Bruxelles | 1070 | Belgium | Details | ||
| GSK Investigational Site | Charleroi | 6000 | Belgium | Details | ||
| GSK Investigational Site | Gent | 9000 | Belgium | Details | ||
| GSK Investigational Site | Leuven | 3000 | Belgium | Details | ||
| GSK Investigational Site | Ondina | Bahia | 40170-110 | Brazil | Details | |
| GSK Investigational Site | Vitória | Espírito Santo | 29043-260 | Brazil | Details | |
| GSK Investigational Site | Belo Horizonte | Minas Gerais | 30130-100 | Brazil | Details | |
| GSK Investigational Site | Caxias do Sul | Rio Grande Do Sul | 95070-560 | Brazil | Details | |
| GSK Investigational Site | Porto Alegre | Rio Grande Do Sul | 90020-090 | Brazil | Details | |
| GSK Investigational Site | Porto Alegre | Rio Grande Do Sul | 90610000 | Brazil | Details | |
| GSK Investigational Site | Florianopolis | Santa Catarina | 88034-000 | Brazil | Details | |
| GSK Investigational Site | Rio de Janeiro | 20560-120 | Brazil | Details | ||
| GSK Investigational Site | São Paulo | 01317000 | Brazil | Details | ||
| GSK Investigational Site | São Paulo | 04312903 | Brazil | Details | ||
| GSK Investigational Site | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| GSK Investigational Site | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| GSK Investigational Site | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| GSK Investigational Site | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| GSK Investigational Site | Québec | G1S 4L8 | Canada | Details | ||
| GSK Investigational Site | Temuco | Región De La Araucania | 5360000 | Chile | Details | |
| GSK Investigational Site | Providencia | Región Metro De Santiago | 7500653 | Chile | Details | |
| GSK Investigational Site | Santiago | Región Metro De Santiago | 7500836 | Chile | Details | |
| GSK Investigational Site | Helsinki | 00180 | Finland | Details | ||
| GSK Investigational Site | Helsinki | HUS 00029 | Finland | Details | ||
| GSK Investigational Site | Turku | 20520 | Finland | Details | ||
| GSK Investigational Site | Avignon Cedex 9 | 84918 | France | Details | ||
| GSK Investigational Site | Bordeaux Cedex | 33076 | France | Details | ||
| GSK Investigational Site | Caen | 14000 | France | Details | ||
| GSK Investigational Site | Clermont-Ferrand cedex | 63011 | France | Details | ||
| GSK Investigational Site | Dijon | 21000 | France | Details | ||
| GSK Investigational Site | Marseille Cedex 20 | 13915 | France | Details | ||
| GSK Investigational Site | Montpellier | 34070 | France | Details | ||
| GSK Investigational Site | Pierre-Bénite cedex | 69495 | France | Details | ||
| GSK Investigational Site | Rouen | 76000 | France | Details | ||
| GSK Investigational Site | Saint-Cloud | 92210 | France | Details | ||
| GSK Investigational Site | Mannheim | Baden-Wuerttemberg | 68167 | Germany | Details | |
| GSK Investigational Site | Ulm | Baden-Wuerttemberg | 89075 | Germany | Details | |
| GSK Investigational Site | Erlangen | Bayern | 91054 | Germany | Details | |
| GSK Investigational Site | Muenchen | Bayern | 81377 | Germany | Details | |
| GSK Investigational Site | Essen | Nordrhein-Westfalen | 45136 | Germany | Details | |
| GSK Investigational Site | Koeln | Nordrhein-Westfalen | 50935 | Germany | Details | |
| GSK Investigational Site | Berlin | 13125 | Germany | Details | ||
| GSK Investigational Site | Debrecen | 4032 | Hungary | Details | ||
| GSK Investigational Site | Dublin | 8 | Ireland | Details | ||
| GSK Investigational Site | Dublin | 9 | Ireland | Details | ||
| GSK Investigational Site | Beer Sheva | 84101 | Israel | Details | ||
| GSK Investigational Site | Haifa | 31096 | Israel | Details | ||
| GSK Investigational Site | Jerusalem | 91031 | Israel | Details | ||
| GSK Investigational Site | Jerusalem | 91120 | Israel | Details | ||
| GSK Investigational Site | Petach Tikva | 49100 | Israel | Details | ||
| GSK Investigational Site | Rehovot | 76100 | Israel | Details | ||
| GSK Investigational Site | Tel Aviv | 64239 | Israel | Details | ||
| GSK Investigational Site | Napoli | Campania | 80131 | Italy | Details | |
| GSK Investigational Site | Bologna | Emilia-Romagna | 40138 | Italy | Details | |
| GSK Investigational Site | Meldola (FC) | Emilia-Romagna | 47014 | Italy | Details | |
| GSK Investigational Site | Genova | Liguria | 16132 | Italy | Details | |
| GSK Investigational Site | Milano | Lombardia | 20141 | Italy | Details | |
| GSK Investigational Site | Milano | Lombardia | 20157 | Italy | Details | |
| GSK Investigational Site | Monza (MB) | Lombardia | 20900 | Italy | Details | |
| GSK Investigational Site | Macerata | Marche | 62100 | Italy | Details | |
| GSK Investigational Site | Torrette Di Ancona | Marche | 60126 | Italy | Details | |
| GSK Investigational Site | Candiolo | Piemonte | 10060 | Italy | Details | |
| GSK Investigational Site | Brindisi | Puglia | 72100 | Italy | Details | |
| GSK Investigational Site | Catania | Sicilia | 95122 | Italy | Details | |
| GSK Investigational Site | Negrar (Verona) | Veneto | 37024 | Italy | Details | |
| GSK Investigational Site | Padova | Veneto | 35128 | Italy | Details | |
| GSK Investigational Site | Aichi | 464-8681 | Japan | Details | ||
| GSK Investigational Site | Chiba | 277-8577 | Japan | Details | ||
| GSK Investigational Site | Ehime | 791-0280 | Japan | Details | ||
| GSK Investigational Site | Fukuoka | 811-1395 | Japan | Details | ||
| GSK Investigational Site | Hiroshima | 730-8518 | Japan | Details | ||
| GSK Investigational Site | Hokkaido | 003-0804 | Japan | Details | ||
| GSK Investigational Site | Kagoshima | 892-0833 | Japan | Details | ||
| GSK Investigational Site | Kanagawa | 216-8511 | Japan | Details | ||
| GSK Investigational Site | Kanagawa | 241-8515 | Japan | Details | ||
| GSK Investigational Site | Kanagawa | 259-1143 | Japan | Details | ||
| GSK Investigational Site | Okayama | 700-8558 | Japan | Details | ||
| GSK Investigational Site | Osaka | 541-8567 | Japan | Details | ||
| GSK Investigational Site | Osaka | 589-8511 | Japan | Details | ||
| GSK Investigational Site | Saitama | 350-1298 | Japan | Details | ||
| GSK Investigational Site | Saitama | 350-8550 | Japan | Details | ||
| GSK Investigational Site | Saitama | 362-0806 | Japan | Details | ||
| GSK Investigational Site | Tokyo | 104-0045 | Japan | Details | ||
| GSK Investigational Site | Tokyo | 113-8431 | Japan | Details | ||
| GSK Investigational Site | Tokyo | 135-8550 | Japan | Details | ||
| GSK Investigational Site | Tokyo | 142-8666 | Japan | Details | ||
| GSK Investigational Site | Guanajuato | Leon | 37178 | Mexico | Details | |
| GSK Investigational Site | Monterrey | Nuevo León | 64460 | Mexico | Details | |
| GSK Investigational Site | Monterrey | Nuevo León | 66278 | Mexico | Details | |
| GSK Investigational Site | Ciudad de Mexico | 04980 | Mexico | Details | ||
| GSK Investigational Site | Alkmaar | 1815 JD | Netherlands | Details | ||
| GSK Investigational Site | Den Haag | 2545 AA | Netherlands | Details | ||
| GSK Investigational Site | Leeuwarden | 8934 AD | Netherlands | Details | ||
| GSK Investigational Site | Maastricht | 6229 HX | Netherlands | Details | ||
| GSK Investigational Site | Rotterdam | 3083 AN | Netherlands | Details | ||
| GSK Investigational Site | Zwolle | 8025 AB | Netherlands | Details | ||
| GSK Investigational Site | Drammen | N-3004 | Norway | Details | ||
| GSK Investigational Site | Stavanger | 4011 | Norway | Details | ||
| GSK Investigational Site | Katowice | 40-514 | Poland | Details | ||
| GSK Investigational Site | Krakow | 31-115 | Poland | Details | ||
| GSK Investigational Site | Krakow | 31-501 | Poland | Details | ||
| GSK Investigational Site | Olsztyn | 10-228 | Poland | Details | ||
| GSK Investigational Site | Poznan | 61-866 | Poland | Details | ||
| GSK Investigational Site | Rzeszow | 35-021 | Poland | Details | ||
| GSK Investigational Site | Siedlce | 08-110 | Poland | Details | ||
| GSK Investigational Site | Szczecin | 70-707 | Poland | Details | ||
| GSK Investigational Site | Warszawa | 02-781 | Poland | Details | ||
| GSK Investigational Site | Wroclaw | 53-413 | Poland | Details | ||
| GSK Investigational Site | Lisboa | 1649-035 | Portugal | Details | ||
| GSK Investigational Site | Loures | 2674-514 | Portugal | Details | ||
| GSK Investigational Site | Bucharest | 011171 | Romania | Details | ||
| GSK Investigational Site | Bucharest | 020142 | Romania | Details | ||
| GSK Investigational Site | Bucharest | 022343 | Romania | Details | ||
| GSK Investigational Site | Bucuresti | 021389 | Romania | Details | ||
| GSK Investigational Site | Cluj-Napoca | 400015 | Romania | Details | ||
| GSK Investigational Site | Craiova | 200347 | Romania | Details | ||
| GSK Investigational Site | Otopeni | 075100 | Romania | Details | ||
| GSK Investigational Site | Timisoara | 300239 | Romania | Details | ||
| GSK Investigational Site | Chelyabinsk | 454048 | Russian Federation | Details | ||
| GSK Investigational Site | Moscow | 111123 | Russian Federation | Details | ||
| GSK Investigational Site | Moscow | 121309 | Russian Federation | Details | ||
| GSK Investigational Site | Moscow | 143422 | Russian Federation | Details | ||
| GSK Investigational Site | Omsk | 644013 | Russian Federation | Details | ||
| GSK Investigational Site | Pushkin | 196603 | Russian Federation | Details | ||
| GSK Investigational Site | Saint Petersburg | 197110 | Russian Federation | Details | ||
| GSK Investigational Site | St. Petersburg | 197758 | Russian Federation | Details | ||
| GSK Investigational Site | St.Peterburg | 197022 | Russian Federation | Details | ||
| GSK Investigational Site | Cape Town | 7700 | South Africa | Details | ||
| GSK Investigational Site | Port Elizabeth | 6045 | South Africa | Details | ||
| GSK Investigational Site | Pretoria | 0041 | South Africa | Details | ||
| GSK Investigational Site | Barcelona | 08003 | Spain | Details | ||
| GSK Investigational Site | Barcelona | 08028 | Spain | Details | ||
| GSK Investigational Site | Barcelona | 08035 | Spain | Details | ||
| GSK Investigational Site | Cáceres | 10003 | Spain | Details | ||
| GSK Investigational Site | Córdoba | 14004 | Spain | Details | ||
| GSK Investigational Site | Granada | 18016 | Spain | Details | ||
| GSK Investigational Site | Madrid | 28034 | Spain | Details | ||
| GSK Investigational Site | Madrid | 28041 | Spain | Details | ||
| GSK Investigational Site | Madrid | 28046 | Spain | Details | ||
| GSK Investigational Site | Madrid | 28050 | Spain | Details | ||
| GSK Investigational Site | Murcia | 30008 | Spain | Details | ||
| GSK Investigational Site | Málaga | 29010 | Spain | Details | ||
| GSK Investigational Site | Santiago de Compostela | 15706 | Spain | Details | ||
| GSK Investigational Site | Valencia | 46010 | Spain | Details | ||
| GSK Investigational Site | Zaragoza | 50009 | Spain | Details | ||
| GSK Investigational Site | Basel | 4031 | Switzerland | Details | ||
| GSK Investigational Site | Sutton | Surrey | SM2 5PT | United Kingdom | Details | |
| GSK Investigational Site | Coventry | Warwickshire | CV2 2DX | United Kingdom | Details | |
| GSK Investigational Site | Bath | BA1 3NG | United Kingdom | Details | ||
| GSK Investigational Site | Brighton | BN2 5BE | United Kingdom | Details | ||
| GSK Investigational Site | Cardiff | CF14 2TL | United Kingdom | Details | ||
| GSK Investigational Site | Edinburgh | EH4 2XU | United Kingdom | Details | ||
| GSK Investigational Site | Leeds | LS9 7TF | United Kingdom | Details | ||
| GSK Investigational Site | London | SE1 9RT | United Kingdom | Details | ||
| GSK Investigational Site | London | SW3 6JJ | United Kingdom | Details | ||
| GSK Investigational Site | Maidstone | ME16 9QQ | United Kingdom | Details | ||
| GSK Investigational Site | Manchester | M20 4BX | United Kingdom | Details | ||
| GSK Investigational Site | Wigan. | WN1 2NN | United Kingdom | Details |