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| NCT ID | NCT05217446 |
| Title | A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer (SEAMARK) |
| Acronym | SEAMARK |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | Yes |
| Sponsors | Pfizer |
| Indications | |
| Therapies | |
| Age Groups: | adult | child | senior |
| Covered Countries | USA | SWE | SVK | POL | NOR | NLD | ITA | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BEL | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Mayo Clinic Building - Phoenix | Phoenix | Arizona | 85054 | United States | Details | |
| Mayo Clinic Hospital | Phoenix | Arizona | 85054 | United States | Details | |
| Mayo Clinic | Scottsdale | Arizona | 85259 | United States | Details | |
| Keck Hospital of USC | Los Angeles | California | 90033 | United States | Details | |
| Keck School of Medicine of USC | Los Angeles | California | 90033 | United States | Details | |
| LAC USC Medical Center | Los Angeles | California | 90033 | United States | Details | |
| USC Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | United States | Details | |
| USC/Norris Comprehensive Cancer Center / Investigational Drug Services | Los Angeles | California | 90033 | United States | Details | |
| USC/Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | United States | Details | |
| Keck Hospital of USC Pasadena | Pasadena | California | 91105 | United States | Details | |
| Mount Sinai Cancer Center | Miami Beach | Florida | 33140 | United States | Details | |
| University of Miami Hospital and Clinics, Sylvester Cancer Center | Miami | Florida | 33136 | United States | Details | |
| University of Miami Hospital and Clinics, Sylvester Cancer Center | Plantation | Florida | 33324 | United States | Details | |
| UChicago Medicine - River East | Chicago | Illinois | 60611 | United States | Details | |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | United States | Details | |
| UChicago Medicine at Ingalls - Flossmoor | Flossmoor | Illinois | 60422 | United States | Details | |
| UChicago Medicine Ingalls Memorial | Harvey | Illinois | 60426 | United States | Details | |
| University of Chicago Comprehensive Cancer Center at Silver Cross Hospital | New Lenox | Illinois | 60451 | United States | Details | |
| The University of Chicago Medicine Center of Advanced Care Orland Park | Orland Park | Illinois | 60462 | United States | Details | |
| UChicago Medicine at Ingalls - Tinley Park | Tinley Park | Illinois | 60477 | United States | Details | |
| Mayo Clinic Cancer Center Outpatient Pharmacy | Rochester | Minnesota | 55905 | United States | Details | |
| Mayo Clinic | Rochester | Minnesota | 55905 | United States | Details | |
| Columbia University Medical Center | New York | New York | 10032 | United States | Details | |
| The West Clinic, PLLC dba West Cancer Center | Germantown | Tennessee | 38138 | United States | Details | |
| MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Chris O'Brien Lifehouse | Camperdown | New South Wales | 2050 | Australia | Details | |
| GenesisCare North Shore | St Leonards | New South Wales | 2065 | Australia | Details | |
| Gallipoli Medical Research Foundation | Brisbane | Queensland | 4120 | Australia | Details | |
| Greenslopes Private Hospital | Greenslopes | Queensland | 4120 | Australia | Details | |
| Austin Health | Heidelberg | Victoria | 3084 | Australia | Details | |
| Peter MacCallum Cancer Centre | Melbourne | Victoria | 3000 | Australia | Details | |
| Royal Melbourne Hospital | Parkville | Victoria | 3052 | Australia | Details | |
| Imelda General Hospital | Bonheiden | Antwerpen | 2820 | Belgium | Details | |
| Institut Jules Bordet | Anderlecht | Bruxelles-capitale, Région DE | 1070 | Belgium | Details | |
| Cliniques universitaires Saint-Luc | Brussels | Bruxelles-capitale, Région DE | 1200 | Belgium | Details | |
| UZ Gent | Gent | Oost-vlaanderen | 9000 | Belgium | Details | |
| UZ Leuven | Leuven | Vlaams-brabant | 3000 | Belgium | Details | |
| ZNA Middelheim | Antwerpen | 2020 | Belgium | Details | ||
| William Osler Health System | Brampton | Ontario | L6R 3J7 | Canada | Details | |
| The Ottawa Hospital - General Campus | Ottawa | Ontario | K1H 8L6 | Canada | Details | |
| Sunnybrook Health Sciences - Odette Cancer Centre | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| CIUSSS de l'Est-de-l'Île-de-Montréal | Montreal | Quebec | h1t2m4 | Canada | Details | |
| Saskatoon Cancer Center | Saskatoon | Saskatchewan | S7N4H4 | Canada | Details | |
| Fakultni nemocnice Hradec Kralove | Hradec Kralove | Hradec Králové | 500 05 | Czechia | Details | |
| Fakultni nemocnice Olomouc | Olomouc | Olomoucký KRAJ | 779 00 | Czechia | Details | |
| Fakultni Thomayerova nemocnice | Prague | Praha 4 | 14059 | Czechia | Details | |
| Fakultni nemocnice Bulovka | Prague | Praha 8 | 180 81 | Czechia | Details | |
| Rigshospitalet | Copenhagen | Hovedstaden | 2100 | Denmark | Details | |
| Herlev and Gentofte Hospital | Copenhagen | Hovedstaden | 2730 | Denmark | Details | |
| Aalborg Universitetshospital, Syd | Aalborg | Nordjylland | 9000 | Denmark | Details | |
| Vejle Sygehus | Vejle | Syddanmark | 7100 | Denmark | Details | |
| Hôpital Européen Georges Pompidou | Paris Cedex 15 | Paris | 75015 | France | Details | |
| CHU Estaing | Clermont Ferrand | 63100 | France | Details | ||
| Centre Hospitalier Universitaire Estaing | Clermont-Ferrand | 63100 | France | Details | ||
| Institut Regional du Cancer de Montpellier - ICM Val d'Aurelle | Montpellier Cedex 5 | 34298 | France | Details | ||
| Institut Régional du Cancer Montpellier | Montpellier | 34298 | France | Details | ||
| Hôpital Saint Antoine | Paris | 75571 | France | Details | ||
| Muenchen Klinik Neuperlach, Klinik fuer Haematologie und Onkologie | Muenchen | Bayern | 81737 | Germany | Details | |
| Institut für Klinisch Onkologische Forschung | Frankfurt | Hessen | 60488 | Germany | Details | |
| Klinikum Oldenburg | Oldenburg | Niedersachsen | 26133 | Germany | Details | |
| Studiengesellschaft BSF Unternehmergesellschaft | Halle (Saale) | Sachsen-anhalt | 06108 | Germany | Details | |
| Universitätsklinikum Leipzig | Leipzig | Sachsen | 04103 | Germany | Details | |
| Onkologische Schwerpunktpraxis Kurfuerstendamm | Berlin | 10707 | Germany | Details | ||
| Studiengesellschaft BSF UG | Halle /Saale | 06108 | Germany | Details | ||
| Facharztzentrum Eppendorf | Hamburg | 20249 | Germany | Details | ||
| Policlinico Universitario Monserrato | Monserrato | Cagliari | 09042 | Italy | Details | |
| Azienda Ospedaliera Universitaria dell'Università "Luigi Vanvitelli" Piazza Luigi Miraglia, 2 Napoli | Napoli | Campania | 80131 | Italy | Details | |
| Ospedale di Guastalla | Guastalla | Emilia-romagna | 42016 | Italy | Details | |
| IRCCS Casa Sollievo della Sofferenza | San Giovanni Rotondo | Foggia | 71013 | Italy | Details | |
| ASST Grande Ospedale Metropolitano Niguarda | Milan | Milano | 20162 | Italy | Details | |
| Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia | Candiolo | Torino | 10060 | Italy | Details | |
| Azienda USL Toscana Nord Ovest_Ospedale Civile di Livorno | Livorno | Toscana | 57124 | Italy | Details | |
| Azienda Ospedaliero Universitaria Pisana | Pisa | Toscana | 56126 | Italy | Details | |
| Istituto Oncologico Veneto IRCCS | Padova | Veneto | 35128 | Italy | Details | |
| Fondazione Poliambulanza Istituto Ospedaliero | Brescia | 25124 | Italy | Details | ||
| Istituto Europeo di Oncologia IRCCS | Milano | 20141 | Italy | Details | ||
| Arcispedale Santa Maria Nuova | Reggio Emilia | 42123 | Italy | Details | ||
| Maastricht UMC+ | Maastricht | Limburg | 6229 HX | Netherlands | Details | |
| Haaglanden MC - locatie Antoniushove | Leidschendam | Zuid-holland | 2262 BA | Netherlands | Details | |
| St. Olavs Hospital | Trondheim | Sør-trøndelag | 7030 | Norway | Details | |
| Oslo Universitetssykehus Ullevål | Oslo | 0450 | Norway | Details | ||
| Przychodnia Lekarska KOMED | Konin | Wielkopolskie | 62-500 | Poland | Details | |
| Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im. Ks. B. Markiewicza | Brzozow | 36-200 | Poland | Details | ||
| SPZOZ Wojewodzki Szpital Specjalistyczny nr 4 w Bytomiu | Bytom | 41-902 | Poland | Details | ||
| Copernicus Podmiot Leczniczy Sp. z o.o. Wojewodzkie Centrum Onkologii | Gdansk | 80-219 | Poland | Details | ||
| Radomskie Centrum Onkologii im. Bohaterow Radomskiego Czerwca 76 | Radom | 26-600 | Poland | Details | ||
| Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska Bystrica | Banska Bystrica | 975 17 | Slovakia | Details | ||
| Onkologicky ustav sv. Alzbety, s.r.o. | Bratislava | 812 50 | Slovakia | Details | ||
| Narodny onkologicky ustav | Bratislava | 833 10 | Slovakia | Details | ||
| Vychodoslovensky onkologicky ustav, a.s. | Kosice | 04191 | Slovakia | Details | ||
| CHUS - Hospital Clinico Universitario | Santiago de Compostela | A Coruña [LA Coruña] | 15706 | Spain | Details | |
| Hospital General Universitario de Elche | Elche | Alicante | 03202 | Spain | Details | |
| Hospital Universitari Vall d'Hebron | Barcelona | Barcelona [barcelona] | 08035 | Spain | Details | |
| Hospital Clínic de Barcelona | Barcelona | Catalunya [cataluña] | 08036 | Spain | Details | |
| Institut Català d'Oncologia - L'Hospitalet | L'Hospitalet de Llobregat | Catalunya [cataluña] | 08908 | Spain | Details | |
| Hospital Universitario Ramón y Cajal | Madrid | Madrid, Comunidad DE | 28034 | Spain | Details | |
| Hospital Universitario 12 de Octubre | Madrid | Madrid, Comunidad DE | 28041 | Spain | Details | |
| Hospital General Universitario Gregorio Marañon | Madrid | 28007 | Spain | Details | ||
| Hospital Universitario 12 de Octubre | Madrid | 28041 | Spain | Details | ||
| Hospital Universitario Virgen Del Rocio | Sevilla | 41013 | Spain | Details | ||
| Hospital General Universitario de Valencia | Valencia | 46014 | Spain | Details | ||
| Hospital Universitario Miguel Servet | Zaragoza | 50009 | Spain | Details | ||
| Karolinska Universitetssjukhuset Solna | Solna | Stockholms LÄN [se-01] | 171 64 | Sweden | Details | |
| Södersjukhuset | Stockholm | Stockholms LÄN [se-01] | 11883 | Sweden | Details | |
| Skaraborgs Sjukhus Skövde | Skövde | 541 85 | Sweden | Details | ||
| Aberdeen Royal Infirmary | Aberdeen | Aberdeen CITY | AB25 2ZN | United Kingdom | Details | |
| Guy's & St Thomas's NHS Foundation Trust | London | England | SE1 9RT | United Kingdom | Details | |
| Royal Marsden Hospital (Chelsea) | London | Kensington AND Chelsea | SW3 6JJ | United Kingdom | Details | |
| Guy's & St Thomas' NHS Foundation Trust | London | London, CITY OF | SE1 9RT | United Kingdom | Details | |
| Royal Marsden Hospital (Sutton) | London | Sutton, Surrey | SM2 5PT | United Kingdom | Details | |
| Heartlands Hospital | Birmingham | B9 5SS | United Kingdom | Details | ||
| The Royal Marsden NHS Foundation Trust | London | SW3 6JJ | United Kingdom | Details |