colorectal carcinoma
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ID DOID:0080199
Name colorectal carcinoma
Definition A colorectal cancer that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa.
Source DiseaseOntology.org
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EFO:1001951
Path disease disease of cellular proliferation cancer organ system cancer gastrointestinal system cancer intestinal cancer large intestine cancer colorectal cancer colorectal carcinoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
CD274 positive Pembrolizumab colorectal carcinoma predicted - sensitive detail...
EML4 - ALK Crizotinib colorectal carcinoma predicted - sensitive detail...
EML4 - ALK Lorlatinib colorectal carcinoma predicted - sensitive detail...
MSH6 F1088Lfs*5 MSH6 Y1256* MSH6 A1320Sfs*5 Nivolumab colorectal carcinoma predicted - sensitive detail...
BRAF V600E Mirdametinib + Palbociclib colorectal carcinoma no benefit detail...
BRAF V600E Gedatolisib + Palbociclib colorectal carcinoma sensitive detail...
POLE inact mut N/A colorectal carcinoma not applicable detail...
POLD1 inact mut N/A colorectal carcinoma not applicable detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02611024 Phase Ib/II Irinotecan + Lurbinectedin Pharmacokinetic Study of PM01183 in Combination With Irinotecan in Patients With Selected Solid Tumors Completed USA | ITA | FRA | ESP | DEU | CHE 0
NCT02977156 Phase I Ipilimumab + JX-594 Immunization Strategy With Intra-tumoral Injections of Pexa-Vec With Ipilimumab in Metastatic / Advanced Solid Tumors. (ISI-JX) Completed FRA 0
NCT03264664 Phase I E7386 Study of E7386 in Participants With Selected Advanced Neoplasms Active, not recruiting USA | GBR 0
NCT03287427 Phase I TetMYB + Tislelizumab MYPHISMO: MYB and PD-1 Immunotherapies Against Multiple Oncologies Trial (MYPHISMO) Completed AUS 0
NCT03401294 Phase II Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Conversion From Unresectable To Resectable Metastatic Colorectal Cancer. (CONVERSION) Recruiting CAN 0
NCT03428958 Phase I A Safety Study of NUC-3373 in Combination With Standard Agents Used in Colorectal Cancer Treatment Completed USA | GBR | FRA 0
NCT03517488 Phase I XmAb20717 A Study of XmAb20717 in Subjects With Selected Advanced Solid Tumors (DUET-2) Completed USA 0
NCT03752398 Phase I Izuralimab A Study of XmAb23104 in Subjects With Selected Advanced Solid Tumors (DUET-3) (DUET-3) Completed USA 0
NCT03849469 Phase I Pembrolizumab + XmAb22841 XmAb22841 A Study of XmAb22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tumors (DUET-4) Completed USA 0
NCT03957096 Phase I SGN-CD47M A Safety Study of SGN-CD47M in Patients With Solid Tumors Terminated USA 0
NCT04060407 Phase Ib/II CD24Fc + Ipilimumab + Nivolumab CD24Fc With Ipilimumab and Nivolumab to Decrease irAE (CINDI) (CINDI) Withdrawn USA 0
NCT04096638 Phase I Nivolumab + SB 11285 SB 11285 Evaluating Safety and Efficacy of SB 11285 Alone and in Combination With Nivolumab in Patients With Advanced Solid Tumors Completed USA 0
NCT04672434 Phase I Sym021 + Sym024 Sym024 Sym024 Monotherapy and in Combination With Sym021 in Patients With Advanced Solid Tumor Malignancies Completed USA | CAN 0
NCT04735796 Phase I LM-102 Study of LM-102 in Subjects in Advanced Tumors Terminated USA 0
NCT04752215 Phase I BI 765049 + Ezabenlimab BI 765049 A Study Evaluating Different Doses of BI 765049 When Given Alone and When Given With Ezabenlimab to Patients With Advanced Solid Tumors Expressing the Protein B7-H6 on the Cell Surface Completed USA | CAN 0
NCT04793958 Phase III Adagrasib + Cetuximab Fluorouracil + Leucovorin + Oxaliplatin Fluorouracil + Irinotecan + Leucovorin Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10) Active, not recruiting USA | ROU | POL | NLD | ITA | IRL | GRC | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CAN | BRA | BEL | AUT | AUS | ARG 12
NCT04975256 Phase I Adagrasib + BI 1701963 Adagrasib in Combination With BI 1701963 in Patients With Cancer (KRYSTAL 14) Terminated USA 0
NCT05001516 Phase Ib/II TPX-4589 Study of Turning Point Therapeutics LM-302 in Patients With Advance Solid Tumors Completed USA 0
NCT05217446 Phase II Pembrolizumab Cetuximab + Encorafenib + Pembrolizumab A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer (SEAMARK) Active, not recruiting USA | SVK | POL | NOR | NLD | ITA | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BEL | AUS 0
NCT05378425 Phase I NTX-1088 NTX-1088 + Pembrolizumab A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab Recruiting USA | POL | ISR 0
NCT05625412 Phase I CC-90001 + Nivolumab Capecitabine + CC-90001 CC-90001 CC-90001 + Docetaxel A Study of BMS-986360/CC-90001 Alone and in Combination With Chemotherapy or Nivolumab in Advanced Solid Tumors Completed USA | ITA | FRA | ESP | CAN | AUS | ARG 2
NCT05700656 Phase Ib/II Capecitabine + Galunisertib Galunisertib Combined With Capecitabine in Advanced CRC With PM Recruiting NLD 0
NCT05786924 Phase Ib/II BDTX-4933 + Fluorouracil + Irinotecan + Leucovorin + Panitumumab BDTX-4933 + Cetuximab + Fluorouracil + Irinotecan + Leucovorin BDTX-4933 BDTX-4933 + Fluorouracil + Leucovorin + Oxaliplatin + Panitumumab BDTX-4933 + Cetuximab + Fluorouracil + Leucovorin + Oxaliplatin BDTX-4933 + Gemcitabine + Nab-paclitaxel Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies Recruiting USA 0
NCT05958199 Phase I NPX267 Treatment With NPX267 for Subjects With Solid Tumors Known to Express HHLA-2 Suspended USA 0
NCT06105021 Phase Ib/II AFNT-211 Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor Active, not recruiting USA 0
NCT06120075 Phase I AB801 AB801 + Docetaxel AB801 + Docetaxel + Zimberelimab A Study of AB801 Monotherapy and Combination Therapy in Participants With Advanced Malignancies (ARC-27) Active, not recruiting USA 0
NCT06216561 Phase I CEND-1 Intraperitoneal LSTA1 in CRS-HIPEC Withdrawn USA 0
NCT06240728 Phase I NPX887 A Study of NPX887 for Participants With Solid Tumors Known to Express HHLA2/B7-H7 Recruiting USA 1
NCT06399757 Phase Ib/II APL-5125 A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors Recruiting USA 0
NCT06444815 Phase I VET3-TGI Pembrolizumab + VET3-TGI A Study of VET3-TGI in Patients With Solid Tumors (STEALTH-001) Recruiting USA 0
NCT06462183 Phase I RGT-61159 Study of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC) Recruiting USA | CAN 0
NCT06723236 Phase I MGC028 A Study of MGC028 in Participants with Advanced Solid Tumors Recruiting USA 0
NCT06760819 Phase II Sevabertinib A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2) (panSOHO) Recruiting USA | ITA | FRA | ESP | DNK | CHE | CAN | AUS 3
NCT06840119 Phase Ib/II IMC-R117C Phase 1/2 Study of IMC-R117C in Selected Advanced Cancers Recruiting NLD | ITA | ESP | DEU | BEL | AUS 0
NCT06882746 Phase I BI 765049 A Study to Test Different Doses of BI 765049 in People With Advanced Cancer of the Colon, Rectum, Stomach, or Pancreas Active, not recruiting USA 0
NCT06939283 Phase Ib/II WTX-330 A Phase 1b/2 Multisite Dose-finding and Expansion Study of WTX-330 in Adult Patients With Selected Advanced or Metastatic Solid Tumors or Lymphoma Recruiting USA 0
NCT07107230 Phase I JNJ-95437446 A Study of JNJ-95437446 in Participants With Advanced-Stage Solid Tumors Recruiting USA | ESP 1