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| NCT ID | NCT06556563 |
| Title | EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma (EF-41) |
| Acronym | EF-41 |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | NovoCure GmbH |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | POL | ITA | ISR | GBR | FRA | ESP | DEU | CZE | CHE | CAN |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Mayo Clinic Hospital | ACTIVE_NOT_RECRUITING | Phoenix | Arizona | 85054 | United States | Details |
| University of Southern California | ACTIVE_NOT_RECRUITING | Los Angeles | California | 90033 | United States | Details |
| Hoag Memorial Hospital Presbyterian | ACTIVE_NOT_RECRUITING | Newport Beach | California | 92663 | United States | Details |
| Stanford Cancer Institute | ACTIVE_NOT_RECRUITING | Palo Alto | California | 94305 | United States | Details |
| University of California | ACTIVE_NOT_RECRUITING | San Francisco | California | 94143 | United States | Details |
| MedStar Georgetown University Hospital | ACTIVE_NOT_RECRUITING | Washington D.C. | District of Columbia | 20007 | United States | Details |
| UF Health Neuromedicine | ACTIVE_NOT_RECRUITING | Gainesville | Florida | 32608 | United States | Details |
| Mayo Clinic - Florida | ACTIVE_NOT_RECRUITING | Jacksonville | Florida | 32224 | United States | Details |
| Miami Cancer Institute | ACTIVE_NOT_RECRUITING | Miami | Florida | 33176 | United States | Details |
| Moffitt Cancer Center | ACTIVE_NOT_RECRUITING | Tampa | Florida | 33612 | United States | Details |
| Northwestern Memorial Hospital | ACTIVE_NOT_RECRUITING | Chicago | Illinois | 60611 | United States | Details |
| University of Kentucky Medical Center | ACTIVE_NOT_RECRUITING | Lexington | Kentucky | 40536 | United States | Details |
| Norton Cancer Institute | ACTIVE_NOT_RECRUITING | Louisville | Kentucky | 40241 | United States | Details |
| University of Maryland | ACTIVE_NOT_RECRUITING | Baltimore | Maryland | 21201 | United States | Details |
| Tufts Medical Center | ACTIVE_NOT_RECRUITING | Boston | Massachusetts | 02111 | United States | Details |
| Masonic Cancer Center, University of Minnesota | ACTIVE_NOT_RECRUITING | Minneapolis | Minnesota | 55455 | United States | Details |
| Mayo Clinic - Rochester | ACTIVE_NOT_RECRUITING | Rochester | Minnesota | 55905 | United States | Details |
| Washington University | ACTIVE_NOT_RECRUITING | St Louis | Missouri | 63110 | United States | Details |
| Renown Regional Medical Center | ACTIVE_NOT_RECRUITING | Reno | Nevada | 89502 | United States | Details |
| John Theurer Cancer Center/ Hackensack Meridian Health | ACTIVE_NOT_RECRUITING | Hackensack | New Jersey | 07601 | United States | Details |
| Rutgers Cancer Institute of New Jersey University Hospital | ACTIVE_NOT_RECRUITING | New Brunswick | New Jersey | 08901 | United States | Details |
| Northwell Health | ACTIVE_NOT_RECRUITING | Lake Success | New York | 11042 | United States | Details |
| Columbia University Irving Medical Center | ACTIVE_NOT_RECRUITING | New York | New York | 10032 | United States | Details |
| Montefiore Medical Center- Montefiore Medical Park | ACTIVE_NOT_RECRUITING | The Bronx | New York | 10461 | United States | Details |
| Duke University Medical Center | ACTIVE_NOT_RECRUITING | Durham | North Carolina | 27710 | United States | Details |
| University of Cincinnati Cancer Institute | ACTIVE_NOT_RECRUITING | Cincinnati | Ohio | 45219 | United States | Details |
| University Hospitals Cleveland Medical Center | ACTIVE_NOT_RECRUITING | Cleveland | Ohio | 44106 | United States | Details |
| The Cleveland Clinic | ACTIVE_NOT_RECRUITING | Cleveland | Ohio | 44195 | United States | Details |
| Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center, Clinical Trials Organization | ACTIVE_NOT_RECRUITING | Philadelphia | Pennsylvania | 19107 | United States | Details |
| UPMC Hillman Cancer Center | ACTIVE_NOT_RECRUITING | Pittsburgh | Pennsylvania | 15232 | United States | Details |
| Rhode Island Hospital | ACTIVE_NOT_RECRUITING | Providence | Rhode Island | 02903 | United States | Details |
| The University of Texas | ACTIVE_NOT_RECRUITING | Houston | Texas | 77030 | United States | Details |
| University of Texas, MD Anderson Cancer Center | ACTIVE_NOT_RECRUITING | Houston | Texas | 77030 | United States | Details |
| Huntsman Cancer Institute, University of Utah | ACTIVE_NOT_RECRUITING | Salt Lake City | Utah | 84112 | United States | Details |
| Inova Schar Cancer Institute | ACTIVE_NOT_RECRUITING | Fairfax | Virginia | 22031 | United States | Details |
| Swedish Medical Center | ACTIVE_NOT_RECRUITING | Seattle | Washington | 98122 | United States | Details |
| Cross Cancer Institute | RECRUITING | Edmonton | Alberta | T6G 1Z2 | Canada | Details |
| Hamilton Health Sciences-Juravinski Cancer Centre | RECRUITING | Hamilton | Ontario | L8V 5C2 | Canada | Details |
| The Ottawa Hospital Cancer Centre | RECRUITING | Ottawa | Ontario | K1H 8L6 | Canada | Details |
| University Health Network - Princess Margaret Cancer Centre | RECRUITING | Toronto | Ontario | M5G 2C1 | Canada | Details |
| CHUM | RECRUITING | Montreal | Quebec | H2X 3E4 | Canada | Details |
| Montreal Neurological Institute-Hospital, Clinical Research Unit | RECRUITING | Montreal | Quebec | H3A 2B4 | Canada | Details |
| Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke (CIUSSS de l'Estrie-CHUS) | RECRUITING | Sherbrooke | Quebec | J1H 5N4 | Canada | Details |
| Nemocnice Na Homolce | ACTIVE_NOT_RECRUITING | Prague | 150 30 | Czechia | Details | |
| Centre Hospitalier Universitaire de Lyon | ACTIVE_NOT_RECRUITING | Bron | 69500 | France | Details | |
| Hopital de la Timone | ACTIVE_NOT_RECRUITING | Marseille | 13385 | France | Details | |
| Hopital Saint-Louis | ACTIVE_NOT_RECRUITING | Paris | 75010 | France | Details | |
| Groupe Hospitalier Pitie - Salpetriere | ACTIVE_NOT_RECRUITING | Paris | 75013 | France | Details | |
| Institut Claudius Regaud | ACTIVE_NOT_RECRUITING | Toulouse | 31059 | France | Details | |
| Charité Campus Virchow-Klinikum | ACTIVE_NOT_RECRUITING | Berlin | 10117 | Germany | Details | |
| Universitätsklinikum Essen | ACTIVE_NOT_RECRUITING | Essen | 45147 | Germany | Details | |
| University Hospital Frankfurt | ACTIVE_NOT_RECRUITING | Frankfurt | 60528 | Germany | Details | |
| Rambam Medical Center | ACTIVE_NOT_RECRUITING | Haifa | 3109601 | Israel | Details | |
| Rabin Medical Center- Beilinson Hospital | ACTIVE_NOT_RECRUITING | Petah Tikva | 4941492 | Israel | Details | |
| Chaim Sheba Medical Center | ACTIVE_NOT_RECRUITING | Ramat Gan | 5265601 | Israel | Details | |
| Tel-Aviv Sourasky Medical Center | ACTIVE_NOT_RECRUITING | Tel Aviv | 64239 | Israel | Details | |
| Neuro-Oncologia Clinica Ospedale Molinette - AOU Città della Salute e della Scienza di Torino | ACTIVE_NOT_RECRUITING | Torino | Torino | 10126 | Italy | Details |
| Ospedale Bellaria | ACTIVE_NOT_RECRUITING | Bologna | 40139 | Italy | Details | |
| Fondazione IRCCS Istituto Neurologico Carlo Besta | ACTIVE_NOT_RECRUITING | Milan | 20133 | Italy | Details | |
| Ospedale del Mare | ACTIVE_NOT_RECRUITING | Naples | 80147 | Italy | Details | |
| UOC Oncologia Medica 1 Istituto Oncologico Veneto IOV-IRCCS | ACTIVE_NOT_RECRUITING | Padova | 35128 | Italy | Details | |
| IRCCS Istituto Clinico Humanitas | ACTIVE_NOT_RECRUITING | Rozzano | 20089 | Italy | Details | |
| U.O.C. Immunoterapia Oncologica A.O.U. Senese, Policlinico Santa Maria alle Scotte | ACTIVE_NOT_RECRUITING | Siena | 53100 | Italy | Details | |
| Fujita Health University Hospital | RECRUITING | Toyoake-shi | Aichi-ken | 470-1192 | Japan | Details |
| Tokai University Hospital | RECRUITING | Isehara | Kanagawa | 259-1193 | Japan | Details |
| Kyushu University Hospital | RECRUITING | Fukuoka | 812-8582 | Japan | Details | |
| Hokkaido University Hospital | RECRUITING | Hokkaido | 060-8648 | Japan | Details | |
| Kanazawa University Hospital | RECRUITING | Ishikawa | 920-8641 | Japan | Details | |
| Kumamoto University Hospital | RECRUITING | Kumamoto | 860-8556 | Japan | Details | |
| Kyoto University Hospital | RECRUITING | Kyoto | 606-8507 | Japan | Details | |
| Kyorin University Hospital | RECRUITING | Mitaka | 181-8611 | Japan | Details | |
| Nagoya University Hospital | RECRUITING | Nagoya | 466-8560 | Japan | Details | |
| Saitama Medical University International Medical Center | RECRUITING | Saitama | 350-1298 | Japan | Details | |
| Tohoku University Hospital | RECRUITING | Sendai | 980-8574 | Japan | Details | |
| National Cancer Center Hospital | RECRUITING | Tokyo | 104-0045 | Japan | Details | |
| Centrum Onkologii | ACTIVE_NOT_RECRUITING | Bydgoszcz | 85-796 | Poland | Details | |
| Narodowy Instytut Onkologii | ACTIVE_NOT_RECRUITING | Gliwice | 44-102 | Poland | Details | |
| Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika-Zakład Teleradioterapii | ACTIVE_NOT_RECRUITING | Lodz | 93-513 | Poland | Details | |
| Hospital Universitario Clínico San Carlos | ACTIVE_NOT_RECRUITING | Madrid | Madrid | 28040 | Spain | Details |
| Hospital Universitari Vall d'Hebron | ACTIVE_NOT_RECRUITING | Barcelona | 08035 | Spain | Details | |
| Institut Català d'Oncologia de L'Hospitalet (ICO L'Hospitalet) | ACTIVE_NOT_RECRUITING | Barcelona | 08908 | Spain | Details | |
| Hospital Universitario Reina Sofia | ACTIVE_NOT_RECRUITING | Córdoba | 14004 | Spain | Details | |
| Hospital Universitario Virgen de las Nieves | ACTIVE_NOT_RECRUITING | Granada | 18014 | Spain | Details | |
| Hospital Universitario Ramón y Cajal | ACTIVE_NOT_RECRUITING | Madrid | 28034 | Spain | Details | |
| Hospital Universitario 12 de Octubre | ACTIVE_NOT_RECRUITING | Madrid | 28041 | Spain | Details | |
| Hospital Universitario La Paz | ACTIVE_NOT_RECRUITING | Madrid | 28046 | Spain | Details | |
| Hospital Universitario Virgen del Rocio | ACTIVE_NOT_RECRUITING | Seville | 41013 | Spain | Details | |
| Hospital Universitari i Politécnic La Fe | ACTIVE_NOT_RECRUITING | Valencia | 46026 | Spain | Details | |
| University Hospital Basel Medical Oncology | ACTIVE_NOT_RECRUITING | Basel | 4031 | Switzerland | Details | |
| Centre Hospitalier Universitaire Vaudois (CHUV) | ACTIVE_NOT_RECRUITING | Lausanne | 1005 | Switzerland | Details | |
| University Hospital Zurich | ACTIVE_NOT_RECRUITING | Zurich | 8091 | Switzerland | Details | |
| Charing Cross Hospital | ACTIVE_NOT_RECRUITING | London | Greater London | W6 8RF | United Kingdom | Details |
| Mount Vernon Cancer Centre | ACTIVE_NOT_RECRUITING | Northwood | Middlesex | HA6 2RN | United Kingdom | Details |
| Queen Elizabeth | ACTIVE_NOT_RECRUITING | Birmingham | B15 2TH | United Kingdom | Details | |
| Addenbrooke's Hospital (Cambridge University Hospitals NHS Foundation Trust) | ACTIVE_NOT_RECRUITING | Cambridge | CB2 0QQ | United Kingdom | Details | |
| Velindre Cancer Centre | ACTIVE_NOT_RECRUITING | Cardiff | CF14 2TL | United Kingdom | Details | |
| Western General Hospital | ACTIVE_NOT_RECRUITING | Edinburgh | EH4 2XU | United Kingdom | Details | |
| The Clatterbridge Cancer Centre (Clatterbridge Cancer Centre NHS Foundation Trust) | ACTIVE_NOT_RECRUITING | Liverpool | L7 8YA | United Kingdom | Details | |
| The Christie Hospital | ACTIVE_NOT_RECRUITING | Manchester | M20 4BX | United Kingdom | Details | |
| Weston Park Hospital | ACTIVE_NOT_RECRUITING | Sheffield | S10 2SJ | United Kingdom | Details | |
| Southampton General Hospital | ACTIVE_NOT_RECRUITING | Southampton | SO16 6YD | United Kingdom | Details | |
| Royal Marsden | ACTIVE_NOT_RECRUITING | Sutton | SM2 5PT | United Kingdom | Details |