chordoma
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ID DOID:3302
Name chordoma
Definition A notochordal cancer that derives_from cellular remnants of the notochord.
Source DiseaseOntology.org
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ICDO:9370/3
SNOMEDCT_US_2023_03_01:50007008
Path disease disease of cellular proliferation cancer organ system cancer musculoskeletal system cancer connective tissue cancer bone cancer notochordal cancer chordoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
CDKN2A loss Palbociclib chordoma sensitive detail...
CDKN2A loss Abemaciclib chordoma sensitive detail...
CD274 positive Pembrolizumab chordoma predicted - sensitive detail...
MLH1 negative Pembrolizumab chordoma sensitive detail...
PMS2 negative Pembrolizumab chordoma sensitive detail...
MSH2 negative Pembrolizumab chordoma sensitive detail...
MSH6 negative Pembrolizumab chordoma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01407198 Phase I Nilotinib Nilotinib With Radiation for High Risk Chordoma Completed USA 0
NCT02383498 Phase II GI-6301 The National Cancer Institute Opens A Randomized, Double-Blind, Phase 2 Trial of GI-6301 (Yeast-Brachyury Vaccine) Versus Placebo in Combination With Standard of Care Definitive Radiotherapy in Locally Advanced, Unresectable, Chordoma Completed USA 0
NCT02389244 Phase II Regorafenib A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas (REGOBONE) Active, not recruiting FRA 0
NCT02601950 Phase II Tazemetostat A Study of Tazemetostat in Adult Participants With Soft Tissue Sarcoma Completed USA | ITA | GBR | FRA | DEU | CAN | BEL | AUS 1
NCT02989636 Phase I Nivolumab Nivolumab With or Without Stereotactic Radiosurgery in Treating Patients With Recurrent, Advanced, or Metastatic Chordoma Active, not recruiting USA 0
NCT03083678 Phase II Afatinib Afatinib in Locally Advanced and Metastatic Chordoma Completed NLD | ITA | GBR 0
NCT03110744 Phase II Palbociclib CDK4/6 Inhibition in Locally Advanced/Metastatic Chordoma (NCT-PMO-1601) Completed DEU 0
NCT03173950 Phase II Nivolumab Immune Checkpoint Inhibitor Nivolumab in People With Select Rare CNS Cancers Completed USA 0
NCT03242382 Phase II Palbociclib Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression. (PalboSarc) Unknown status ESP 0
NCT03623854 Phase II Nivolumab + Relatlimab Nivolumab and Relatlimab in Treating Participants With Advanced Chordoma Completed USA 0
NCT03647423 Phase Ib/II Aldoxorubicin + Avelumab + Cetuximab + ETBX-051 + ETBX-061 + GI-6301 + haNK cells + Nogapendekin alfa inbakicept QUILT-3.091 NANT Chordoma Vaccine vs Radiation in Subjects With Unresectable Chordoma. Withdrawn USA 0
NCT03886311 Phase II Nivolumab + Talimogene laherparepvec + Trabectedin Talimogene Laherparepvec, Nivolumab and Trabectedin for Sarcoma (TNT) Recruiting USA 0
NCT04040205 Phase II Abemaciclib Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration Recruiting USA 0
NCT04134312 Phase I MVA-BN-Brachyury A Phase 1 Open Label Trial of Intravenous Administration of MVA-BN-Brachyury Vaccine in Patients With Advanced Cancer Completed USA 0
NCT04246671 Phase Ib/II TAEK-VAC-HerBy Pertuzumab + TAEK-VAC-HerBy + Trastuzumab Ado-trastuzumab emtansine + TAEK-VAC-HerBy TAEK-VAC-HerBy + Trastuzumab TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer Completed USA 0
NCT04416568 Phase II Ipilimumab + Nivolumab Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers Active, not recruiting USA 0
NCT04718675 Phase Ib/II KB-0742 A Study of KB-0742 in Participants With Relapsed or Refractory Solid Tumors Including Platinum Resistant High Grade Serous Ovarian Cancer (HGSOC) Terminated USA | GBR | ESP 0
NCT04741438 Phase III Ipilimumab + Nivolumab Pazopanib Efficacy of the Combination of Nivolumab and Ipilimumab as a Treatment in Patients With Sarcoma of Rare Subtype (RAR-Immune) Unknown status FRA 0
NCT04965753 Phase I FHD-609 FHD-609 in Subjects With Advanced Synovial Sarcoma or Advanced SMARCB1-Loss Tumors Terminated USA | ITA | FRA | ESP 0
NCT05041127 Phase II Cetuximab Cetuximab for the Treatment of Advanced Unresectable or Metastatic Chordoma Recruiting USA 0
NCT05286801 Phase Ib/II Atezolizumab + Tiragolumab Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors Active, not recruiting USA | CAN | AUS 0
NCT05407441 Phase Ib/II Ipilimumab + Nivolumab + Tazemetostat Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors Recruiting USA 0
NCT06794645 Phase II Pembrolizumab Pembrolizumab + Pemetrexed Disodium Pembrolizumab and Pemetrexed for Progressive Chordoma Recruiting USA 0
NCT06957327 Phase Ib/II ERAS-601 A Study of ERAS-601 in People With Chordoma Recruiting USA 0
NCT07193550 Phase II XL092 A Phase 2 Trial of Zanzalintinib in Advanced/Metastatic Bone Sarcomas (ZAMBONE) Active, not recruiting USA 0