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ID DOID:5525
Name anal squamous cell carcinoma
Definition An anal carcinoma that arises near the squamocolumnar junction.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer gastrointestinal system cancer intestinal cancer large intestine cancer anus cancer anal carcinoma anal squamous cell carcinoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT00316888 Phase II Cetuximab + Cisplatin + Fluorouracil + Radiotherapy Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Stage I, Stage II, or Stage III Anal Cancer Completed USA 0
NCT03212469 Phase Ib/II Durvalumab + Tremelimumab A Trial of Durvalumab and Tremelimumab in Combination With SBRT in Patients With Metastatic Cancer (ABIMMUNE) Active, not recruiting FRA 0
NCT03357757 Phase II Avelumab + Valproic acid Avelumab With Valproic Acid in Virus-associated Cancer (LATENT) Active, not recruiting CAN 0
NCT03386500 Phase I BMX-001 Safety Study of BMX-001 (Radio-protector) in Patients With Newly Diagnosed Anal Cancer Recruiting USA 0
NCT03519295 Phase II Cisplatin + Docetaxel + Fluorouracil Atezolizumab + Cisplatin + Docetaxel + Fluorouracil A Study of mDCF in Combination or Not With Atezolizumab in Advanced Squamous Cell Anal Carcinoma (SCARCE) Active, not recruiting FRA 0
NCT03946358 Phase II Atezolizumab + UCPVax Combination of UCPVax Vaccine and Atezolizumab for the Treatment of Human Papillomavirus Positive Cancers (VolATIL) (VolATIL) Active, not recruiting FRA 0
NCT04046133 Phase I Pembrolizumab Phase 1b/II Trial of Pembrolizumab Plus IMRT in Stage III/IV Carcinoma of Anus (CORINTH) Unknown status NOR | GBR 0
NCT04230759 Phase II Durvalumab + Fluorouracil + Mitomycin C Fluorouracil + Mitomycin C Radiochemotherapy +/- Durvalumab for Locally-advanced Anal Carcinoma. A Multicenter, Randomized, Phase II Trial of the German Anal Cancer Study Group (RADIANCE) Active, not recruiting DEU | CHE | AUT 0
NCT04444921 Phase III Carboplatin + Paclitaxel Carboplatin + Nivolumab + Paclitaxel Testing the Addition of Nivolumab to Chemotherapy for Patients With Metastatic Anal Cancer Active, not recruiting USA 0
NCT04450901 Phase I YBL-006 Dose Escalation/Dose Expansion Study of YBL-006 in Patients With Advanced Solid Tumors Active, not recruiting AUS 2
NCT04472429 Phase III Carboplatin + Paclitaxel Carboplatin + Paclitaxel + Retifanlimab Carboplatin-paclitaxel With Retifanlimab or Placebo in Participants With Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (POD1UM-303/InterAACT 2). Active, not recruiting USA | SWE | NOR | ITA | GBR | FRA | ESP | DNK | DEU | BEL | AUS 2
NCT04536922 Phase II Aldesleukin + Cyclophosphamide + Fludarabine + iTCR-transduced PBL + Pembrolizumab Single Patient Protocol: A Study Using the Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated or Viral Neoantigens in a Patient With Metastatic Cancer Plus the Administration of Pembrolizu... Withdrawn USA 0
NCT04929028 Phase II Capecitabine + Mitomycin C Nivolumab Fluorouracil + Mitomycin C Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer Recruiting USA 0
NCT05544929 Phase I KFA115 KFA115 + Pembrolizumab A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers Recruiting USA | ITA | ESP | DEU | CAN 4
NCT06493019 Phase II Carboplatin + Paclitaxel + Pembrolizumab Study of Pembrolizumab, Carboplatin, Paclitaxel, and Radiation for the Treatment of Early-Stage Anal Cancer Recruiting USA 0
NCT06526819 Phase Ib/II SMP-3124 A Phase 1/2 Study of SMP-3124LP in Adults With Advanced Solid Tumors Recruiting USA 1
NCT06669572 Phase II Lenvatinib + Pembrolizumab Lenvatinib and Pembrolizumab to Treat Patients With Anal or Rectum Cancer That Has Gotten Worse After Initial Treatment Not yet recruiting USA 0