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ID DOID:8632
Name Kaposi's sarcoma
Definition A connective tissue cancer that derives_from lymphatic endothelium, and derives_from spindle cells, results_in_formation_of vascular channels that fill with blood cells, has_material_basis_in Human herpesvirus 8 (HHV8).
Source DiseaseOntology.org
Alt Ids DOID:12776 DOID:12770 DOID:7239 DOID:12767 DOID:12778 DOID:12766 DOID:12777 DOID:12771 DOID:12762 DOID:6480 DOID:12761 DOID:12772 DOID:12768 DOID:12764 DOID:12775 DOID:8631 DOID:12774
Path disease disease of cellular proliferation cancer organ system cancer musculoskeletal system cancer connective tissue cancer Kaposi's sarcoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT00092222 Phase II Sirolimus Alpha 2 Interferon Cyclophosphamide + Doxorubicin + Etoposide + Prednisone + Vincristine Sulfate Rituximab Bortezomib Pegylated liposomal doxorubicin Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity Active, not recruiting USA 0
NCT00923936 Phase II Bevacizumab + Pegylated liposomal doxorubicin Pilot Study of Liposomal Doxorubicin Combined With Bevacizumab Followed by Bevacizumab Monotherapy in Adults With Advanced Kaposi s Sarcoma Completed USA 0
NCT02137564 Phase II Nirogacestat Gamma Secretase Inhibitor PF-03084014 in Treating Patients With AIDS-Associated Kaposi Sarcoma Withdrawn 0
NCT02408861 Phase I Ipilimumab + Nivolumab Nivolumab and Ipilimumab in Treating Patients With Advanced HIV Associated Solid Tumors Terminated USA | AUS 0
NCT02595866 Phase I Pembrolizumab Pembrolizumab in Treating Patients With HIV and Relapsed, Refractory, or Disseminated Malignant Neoplasms Completed USA 0
NCT03316274 Phase I Nivolumab Intra-lesional Nivolumab Therapy for Limited Cutaneous Kaposi Sarcoma Completed USA 0
NCT03469804 Phase II Pembrolizumab Phase II Multicentric Study of Pembrolizumab in Classic or Endemic Kaposi's Sarcoma (KAPKEY) Unknown status FRA 0
NCT03915678 Phase II Atezolizumab + EIK1001 Atezolizumab Combined With BDB001 AnD Immunogenic Radiotherapy in Patients With Advanced Solid Tumors (AGADIR) Recruiting FRA 0
NCT03993106 Phase II sEphB4-HSA A Study of sEphB4-HSA in Kaposi Sarcoma Recruiting USA 0
NCT04065152 Phase II Talimogene laherparepvec Phase II Multicenter Study of Talimogene Laherparepvec in Classic or Endemic Kaposi Sarcoma (KAPVEC) Unknown status FRA 0
NCT04303117 Phase Ib/II NHS-IL12 Bintrafusp alfa + NHS-IL12 NHS-IL12 Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma Recruiting USA 0
NCT04514484 Phase I Cabozantinib + Nivolumab Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV Active, not recruiting USA 0
NCT04893018 Phase I NT-I7 NT-I7 for Kaposi Sarcoma in Patients With or Without HIV Terminated USA 0
NCT04902443 Phase I Nivolumab + Pomalidomide Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV Recruiting USA 0
NCT04941274 Phase Ib/II Abemaciclib Abemaciclib in Patients With HIV-associated and HIV-negative Kaposi Sarcoma Recruiting USA 0
NCT05006794 Phase I GS-9716 + Sacituzumab govitecan-hziy GS-9716 Docetaxel + GS-9716 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of GS-9716 as Monotherapy and in Combination With Anticancer Therapies in Adults With Solid Malignancies Recruiting USA | ISR 0
NCT05329792 Phase II Daromun L19IL2/L19TNF in Skin Cancer Patients Recruiting ITA | FRA | ESP 0
NCT05646082 Phase I Dostarlimab-gxly Preliminary Assessment of Safety and Tolerability of Dostarlimab in Combination Antiretroviral Therapy (cART) Refractory HIV Associated Kaposi Sarcoma (STARKAP) Recruiting GBR 0
NCT05859074 Phase I MQ710 + Pembrolizumab MQ710 A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer Active, not recruiting USA 0
NCT06638931 Phase II Nivolumab Agnostic Therapy in Rare Solid Tumors (ANTARES) Recruiting BRA 0