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Drug Name | CZ48 |
Trade Name | |
Synonyms | CZ 48|CZ-48|Camptothecin-20(S)-O-Propionate Hydrate |
Drug Descriptions |
CZ48 is a camptothecin prodrug that upon intracellular activation stabilizes the covalent complex between topoisomerase I (TOP1) and DNA, and inhibits religation of single-strand DNA breaks induced by TOP1, which potentially blocks DNA replication and increases tumor cell death (PMID: 31213802). |
DrugClasses | TOPO1 inhibitor 11 |
CAS Registry Number | 194414-69-2 |
NCIT ID | C84857 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
CZ48 | CZ48 | 0 | 1 |