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Drug Detail
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| Drug Name | AMG 397 |
| Trade Name | |
| Synonyms | AMG-397|AMG397|Murizatoclax |
| Drug Descriptions |
AMG 397 is a small molecule inhibitor of MCL1 that selectively disrupts the interaction with members of the Bcl2 family, potentially resulting in increased cellular apoptosis, decreased cell viability, and reduced tumor growth (Cancer Res 2020;80(16 Suppl):Abstract nr 6218). |
| DrugClasses | MCL1 Inhibitor 18 |
| CAS Registry Number | 2245848-05-7 |
| NCIT ID | C156740 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| AMG 397 | AMG 397 | 0 | 1 |
| AMG 397 + Azacitidine | AMG 397 Azacitidine | 0 | 1 |
| AMG 397 + Dexamethasone | AMG 397 Dexamethasone | 0 | 1 |
| AMG 397 + Venetoclax | AMG 397 Venetoclax | 0 | 0 |
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