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Drug Name | BOLD-100 |
Trade Name | |
Synonyms | BOLD100|BOLD 100|IT-139|NKP1339|KP1339 |
Drug Descriptions |
BOLD-100 is a ruthenium-based small molecule therapeutic that inhibits stress-induced overexpression of GRP78 and may induce increased levels of reactive oxygen species and inhibit DNA repair pathways, potentially leading to decreased tumor cell proliferation and reduced tumor growth (PMID: 32947941, PMID: 36077664). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C173373 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
BOLD-100 | BOLD-100 | 0 | 0 |
BOLD-100 + Fluorouracil + Leucovorin + Oxaliplatin | BOLD-100 Fluorouracil Leucovorin Oxaliplatin | 0 | 1 |