HPN328
Drug Detail
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| Drug Name | HPN328 |
| Trade Name | |
| Synonyms | HPN-328|DLL3/CD3e TriTAC HPN328|MK-6070|Gocatamig|HPN 328 |
| Drug Descriptions |
HPN328 is a tri-specific T-cell activating construct (TriTAC) consisting of an antibody targeting DLL3 and a single-chain fragment targeting CD3, which potentially induces T-cell recruitment and inhibits growth of DLL3-expressing tumors (PMID: 38670552). |
| DrugClasses | DLL3 Antibody 10 |
| CAS Registry Number | 2851862-91-2 |
| NCIT ID | C175947 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Atezolizumab + HPN328 | Atezolizumab HPN328 | 0 | 1 |
| Durvalumab + HPN328 | Durvalumab HPN328 | 0 | 1 |
| HPN328 | HPN328 | 0 | 2 |
| HPN328 + Ifinatamab deruxtecan | HPN328 Ifinatamab deruxtecan | 0 | 1 |
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