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Drug Name | HPN328 |
Trade Name | |
Synonyms | HPN-328|DLL3/CD3e TriTAC HPN328|Anti-DLL3 T-cell Engager HPN328|MK-6070 |
Drug Descriptions |
HPN328 is a tri-specific T-cell activating construct (TriTAC) consisting of an antibody targeting DLL3 and a single-chain fragment targeting CD3, which potentially induces T-cell recruitment and inhibits growth of DLL3-expressing tumors (PMID: 38670552). |
DrugClasses | DLL3 Antibody 6 |
CAS Registry Number | 2851862-91-2 |
NCIT ID | C175947 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Atezolizumab + HPN328 | Atezolizumab HPN328 | 0 | 1 |
HPN328 | HPN328 | 0 | 1 |