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Drug Name | RM-018 |
Trade Name | |
Synonyms | RM018|RM 018 |
Drug Descriptions |
RM-018 covalently binds and inhibits GTP-bound KRAS G12C by forming a complex with the chaperone protein cyclophilin A, resulting in decreased downstream signaling and potentially inhibiting tumor growth (PMID: 33824136). |
DrugClasses | KRAS G12C inhibitor 34 |
CAS Registry Number | NA |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
RM-018 | RM-018 | 3 | 0 |