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Drug Name | ARV-825 |
Trade Name | |
Synonyms | ARV825|ARV 825 |
Drug Descriptions |
ARV-825 is a heterobifunctional PROTAC (Proteolysis Targeting Chimera) compound that links OTX015 to Pomalyst (pomalidomide), which targets BRD4 for degradation in a proteosome dependent manner, potentially leading to downregulation of cMyc, decreased proliferation, and increased apoptosis in cancer cells (PMID: 26051217). |
DrugClasses | BRD4 Inhibitor 10 |
CAS Registry Number | 1818885-28-7 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
ARV-825 | ARV-825 | 0 | 0 |
ARV-825 + Crizotinib | ARV-825 Crizotinib | 0 | 0 |