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Drug Name | ORIC-114 |
Trade Name | |
Synonyms | ORIC114|ORIC 114 |
Drug Descriptions |
ORIC-114 is an inhibitor of EGFR and ERBB2 (HER2) targeting exon 20 insertions, which penetrates the blood brain barrier, and may inhibit EGFR phosphorylation and downstream signaling, potentially resulting in anti-tumor activity (Cancer Res 2021;81(13_Suppl):Abstract nr 1466). |
DrugClasses | EGFR Inhibitor (Pan) 62 HER2 Inhibitor 42 |
CAS Registry Number | NA |
NCIT ID | C187334 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Carboplatin + ORIC-114 + Pemetrexed Disodium | Carboplatin ORIC-114 Pemetrexed Disodium | 0 | 1 |
ORIC-114 | ORIC-114 | 0 | 1 |