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Drug Name | TH-Z835 |
Trade Name | |
Synonyms | THZ835|TH Z835 |
Drug Descriptions |
TH-Z835 inhibits KRAS in both GTP- and GDP-bound states, with activity against KRAS G12D, resulting in reduced downstream signaling and potentially leading to increased cell cycle arrest and apoptosis of tumor cells (PMID: 35075146). |
DrugClasses | KRAS G12D Inhibitor 16 |
CAS Registry Number | NA |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
TH-Z835 | TH-Z835 | 0 | 0 |
TH-Z835 + unspecified PD-1 antibody | TH-Z835 unspecified PD-1 antibody | 0 | 0 |